Summary: Poly A polymerase head domain
Poly A polymerase head domain Provide feedback
This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:18.104.22.168. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:22.214.171.124. This family is part of the nucleotidyltransferase superfamily.
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR002646
This group includes nucleic acid independent RNA polymerases, such as polynucleotide adenylyltransferase (EC), which adds the poly (A) tail to mRNA. This group also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||RNA binding (GO:0003723)|
|nucleotidyltransferase activity (GO:0016779)|
|Biological process||RNA processing (GO:0006396)|
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
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This clan contains a diverse set of nucleotidyltransferase enzymes.
The clan contains the following 22 members:Adenyl_cycl_N Adenyl_transf Aminoglyc_resit DNA_pol_B_palm DUF1693 DUF1814 DUF2204 DUF294 DUF925 DZF GlnE GrpB LicD Mab-21 MdcG Mmp37 NTP_transf_2 NTP_transf_5 Nuc-transf PolyA_pol Pox_polyA_pol RelA_SpoT
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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Curation and family details
|Seed source:||Pfam-B_814 (release 4.2)|
|Number in seed:||21|
|Number in full:||6516|
|Average length of the domain:||124.10 aa|
|Average identity of full alignment:||35 %|
|Average coverage of the sequence by the domain:||27.78 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||15|
|Download:||download the raw HMM for this family|
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The tree shows the occurrence of this domain across different species. More...
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There is 1 interaction for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PolyA_pol domain has been found. There are 24 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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