# STOCKHOLM 1.0 #=GF ID Penicil_amidase #=GF AC PF01804.13 #=GF DE Penicillin amidase #=GF AU Bashton M, Bateman A #=GF SE Pfam-B_1410 (release 4.2) #=GF GA 21.30 21.30; #=GF TC 21.80 21.70; #=GF NC 17.40 20.80; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF RN [1] #=GF RM 9292993 #=GF RT Molecular cloning and analysis of the gene encoding the #=GF RT thermostable penicillin G acylase from Alcaligenes faecalis. #=GF RA Verhaert RM, Riemens AM, van der Laan JM, van Duin J, Quax WJ; #=GF RL Appl Environ Microbiol 1997;63:3412-3418. #=GF RN [2] #=GF RM 7816145 #=GF RT Penicillin acylase has a single-amino-acid catalytic centre. #=GF RA Duggleby HJ, Tolley SP, Hill CP, Dodson EJ, Dodson G, Moody PC; #=GF RL Nature 1995;373:264-268. #=GF DR INTERPRO; IPR002692; #=GF DR MEROPS; S45; #=GF DR SCOP; 1pnk; fa; #=GF DR HOMSTRAD; Penicil_amidase; #=GF CC Penicillin amidase or penicillin acylase EC:3.5.1.11 catalyses #=GF CC the hydrolysis of benzylpenicillin to phenylacetic acid and #=GF CC 6-aminopenicillanic acid (6-APA) a key intermediate in the the #=GF CC synthesis of penicillins [1]. Also in the family is #=GF CC cephalosporin acylase Swiss:P07662 and Swiss:P29958 aculeacin A #=GF CC acylase which are involved in the synthesis of related peptide #=GF CC antibiotics. #=GF SQ 21 #=GS O29763_ARCFU/48-774 AC O29763.1 #=GS Q9HKC5_THEAC/40-802 AC Q9HKC5.1 #=GS Q97XS1_SULSO/56-827 AC Q97XS1.1 #=GS Q979D7_THEVO/70-856 AC Q979D7.1 #=GS Q9HI83_THEAC/66-851 AC Q9HI83.1 #=GS Q9I2K4_PSEAE/47-796 AC Q9I2K4.1 #=GS PAC2_PSES3/30-767 AC P15558.2 #=GS Q9AK68_STRCO/1-782 AC Q9AK68.1 #=GS QUIP_PSEAE/54-838 AC Q9I4U2.1 #=GS Q9I6I6_PSEAE/41-787 AC Q9I6I6.1 #=GS Q9A9G3_CAUCR/35-682 AC Q9A9G3.1 #=GS Q9A972_CAUCR/34-719 AC Q9A972.1 #=GS Q9RYQ4_DEIRA/36-778 AC Q9RYQ4.1 #=GS AAC_ACTUT/37-776 AC P29958.1 #=GS PVDQ_PSEAE/31-755 AC Q9I194.1 #=GS PVDQ_PSEAE/31-755 DR PDB; 3L94 A; 31-191; #=GS PVDQ_PSEAE/31-755 DR PDB; 2WYD B; 1-539; #=GS PVDQ_PSEAE/31-755 DR PDB; 2WYC B; 1-539; #=GS PVDQ_PSEAE/31-755 DR PDB; 3SRA A; 31-191; #=GS PVDQ_PSEAE/31-755 DR PDB; 2WYE A; 8-169; #=GS PVDQ_PSEAE/31-755 DR PDB; 3SRC A; 31-192; #=GS PVDQ_PSEAE/31-755 DR PDB; 3SRB B; 217-755; #=GS PVDQ_PSEAE/31-755 DR PDB; 3L91 B; 217-755; #=GS PVDQ_PSEAE/31-755 DR PDB; 2WYE B; 1-539; #=GS PVDQ_PSEAE/31-755 DR PDB; 3L94 B; 217-755; #=GS PVDQ_PSEAE/31-755 DR PDB; 2WYB B; 1-539; #=GS PVDQ_PSEAE/31-755 DR PDB; 3SRB A; 31-191; #=GS PVDQ_PSEAE/31-755 DR PDB; 2WYD A; 8-169; #=GS PVDQ_PSEAE/31-755 DR PDB; 3SRA B; 217-755; #=GS PVDQ_PSEAE/31-755 DR PDB; 2WYB A; 8-169; #=GS PVDQ_PSEAE/31-755 DR PDB; 3SRC B; 217-755; #=GS PVDQ_PSEAE/31-755 DR PDB; 2WYC A; 8-169; #=GS PVDQ_PSEAE/31-755 DR PDB; 3L91 A; 31-192; #=GS O86089_9PROT/45-712 AC O86089.2 #=GS O86089_9PROT/45-712 DR PDB; 2AE3 B; 1-514; #=GS O86089_9PROT/45-712 DR PDB; 2AE4 B; 1-514; #=GS O86089_9PROT/45-712 DR PDB; 2AE5 B; 2-514; #=GS O86089_9PROT/45-712 DR PDB; 1GHD A; 18-161; #=GS O86089_9PROT/45-712 DR PDB; 1GHD B; 1-514; #=GS Q55592_SYNY3/35-700 AC Q55592.1 #=GS Q9S258_STRCO/103-886 AC Q9S258.1 #=GS PAC_ARTVI/30-794 AC P31956.1 #=GS O34142_ALCFA/29-806 AC O34142.1 #=GS O34142_ALCFA/29-806 DR PDB; 3ML0 A; 3-195; #=GS O34142_ALCFA/29-806 DR PDB; 3ML0 B; 1-541; #=GS O34142_ALCFA/29-806 DR PDB; 3K3W B; 1-541; #=GS O34142_ALCFA/29-806 DR PDB; 3K3W A; 3-196; #=GS PAC_KLUCI/31-836 AC P07941.1 O29763_ARCFU/48-774 GWAEVYFDE.YGVPHIVAENEKALAFAVGYVHAKDRLFQMDLHRRMMKGQLSEVFGE...........DFFDSDEFHVKMDFLG......AAEASWSVLKDSE......IGDLLVAYSEGVNYYIK......NRPLPMEFKLAGYK........PKEWTPVDSLLLGKEISWSLTGR.....FWDLERSFIVEKLG.EKALELYPDYLNH..............................S.YPIIRTGMVNKS................L..LEWLKPFEAKDG............FGSNNWVVSGKLTANGKPMLANDPHLLLMAP.PVWYEMHLKV.NGENVRGVSLPGVPVI.LIGMNDYVAWGFTNVGADVIDFYYYVWN....GDKYLYK.GEWLEPEKSIKVVKVKT..KKG..IEERQVVVEKTVHGPVLEKYG..............RKIAVAWTGLTATTEAL.AVYKYNHAHNISEFME.G.LKLFDVPAQNVVYADIYGNVMYYPAGKFPIR.LVNGTEVPGNVIFNGSAGEGEWRGFKP..YGISSWDGFIP.FEE...IPHLINP.........DYVGTANQRVV.........FGYQHY..LGDSMYFAD...PYRGMRIYEMLDEAANSGE.....KITPEYFMKMQRD.VYSKPAEFFTP...............FIFEAEE.........KMSDKARSYAEKLRNWDFRMQKDSEAAL.........IFSIWLDEFVNETFGDEFYSAGLESSFYPHLYVLQN...............LPSNSIWYDDIRTEQREQR.....DDIAARAMEKAVEIIET.................KGYRVYGD...............YNRLEIKHAFSS.........FVKFFDYPSMP........MNGSTYT.VFNFRRAVDWGTG..LSQAGSSWRMIVN...........FDENYCVIPGGNSGNYFSPHYYDQLEMWANGQYKSFDFNVRGEKIVFRE #=GR O29763_ARCFU/48-774 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... Q9HKC5_THEAC/40-802 HDVTIIQDR.YGVYHIYAQDNHDLFLALGFIQAKNRLFELELFKLTAMGELANMLGS...........GYYNYDRFQTMTGAPLTAQRDWNAIVSNMSVNSTDYL....TYQAVTAYSQGINDYINYS.ES.HNLLPFEFNLLDYK........PGYWSPVDTFAVQEYMIQTLEFS.DDSILYSLLSYKIGSLVN.DLITPFSPIPQFY....YGGYNGTP.........NQYVLSMSENTYPINATVASLAV...........SIAK.MWDPLHLFPPNPTD..........H....SNEWVVSGNRTATGKPILVGGPVLGFSLP.SIWFQVQLVD.PHFDVYGVVLPGAPII.VIGYNEHIGWTLTDTQAISWGTFFFVQN.V.VNGTYLWN.GTYQPVKSYIVNGFRVN................WTNLGPILDQNGS.............TAIVMDWLGNMFTNDIG.AILNIMNATNWKQFSS.D.LEIWKAPYQNFAFADINDTIADISPAYYPI..FSSTNAVPYN...PNAIMPGNG.........TQYISGSIP.YSM...VPHAVNPS.......DGFIVSSNQRQV.........GPAYPYW.FGDTMTPSP...GFRAMLEESYLRTHTD.........LTITDMMNLQSHNYTDYEAVMAVP...............YMLKYMAG........YQNATVESALSMLSSWNYSMDVNSRAAS.........VWFFTYMYLFNEIFHTFFKDHGVFPEYRDILNVTGMGGSFPN..SIGIASFDLDMAHMIINDSAYPFSNQ.......SMTNLTASAMIKAMD.................YLESEYP.................SGNYTWGHFYG.........FVFPSLLGISQ........LSVGPLP.RGGDYNTPNDASGV.GPYNWPSGGQSFT...MILNFAN.LSDSYGVYPGGQSENPASPLYSNYINYWINGEYLPLIFYPSASSFPSKS #=GR Q9HKC5_THEAC/40-802 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... Q97XS1_SULSO/56-827 GNVNIYIDS.NGIAHIYANNLHDLFLAEGYYEASQRLFEIELFGLLAMGNLSSWVGA...........KALSSDIAMHLIGIPQ......NAIMSAQYLKHNYPT....IYSYLEAFSQGVNDYIN.T.LN.YRDLPLEFKLLNVR........PYYWSPDYSLAFGEYMGWSLTSGFNDELKSALLYTYFNYSEI.NEINPYYPHFIDG...NLTVIPGDGTV.......NGYNLTDQGISPQYLWSLNWYQSWA.......TGINKDEFKDLVPLMKYAILN..ISDPFI.LFPKFASNSWVITSDFST.QGPILANDPHLPLFDP.SVWIPLQLIA.PAFNVTGWSLVGIPGV.LIGHTAYTAWGLTTPEGSSSDAYLEIV....NGSQYYYN.GKWYQMNEYNYTLMGR............TYTVYYTNNGPLVARYKN.............YGISLYWSAWKEPILTV.ISILLLDNSTSFNDLINA.AKYWVIPPQNLAIVS.KHHAGIIVAGLYPL..INETLPNGKSVLVVGARTPLNGT......VTKYEPIGYIP.FKY...LPQTFDPV.......RGFAFAPNQPTV.........WINYPFP.FIGGFWSS....GGRAEDIYHYLEYQRS.........VNISDMMKLQSN.VTDYWASLLTP...............LIIKAMVN.......NTNGSIQGTAFNYLRNWNFTFYQNEVAPT.........IYTYIVAEMVNNSIAKILNKMGLDILD..IASIP.............Y..IVPDFIYIAQYDPTSIWVNG.......NFTNLVRQSFVKAIS.................LLEQNLGD...............NISQWYWGRVHF.........LEIYNPLGLKA........LSVGPIP.IFGDPHTLAVGSTP.YIPTVPLPYVTIGSSLRFIASPY.SSQFYGIFPGGPSESLVSAFRENQLPLWLSFKYISYSGYNYTIIAKITL #=GR Q97XS1_SULSO/56-827 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... Q979D7_THEVO/70-856 YTVLVFKQA.DGFIGVASNNSNAVFYEQGYLEAQYRLEELDFLKRTALGNLSAVVGQ...........TTLSTDILMRELQFYN......TAVEEYQNLPKTS.F....TYESLHAFVSGINAYIQ.N.LT.YSKLPILFKILNYE........PHKWNVTDVLAVQQLFLWENSAGGFDPVYFNIALEKMPESLI.KAIYPAYPAGIQHPIVPYNLNPSVYNE.......TGDISNLSLYTPSFNVTYSLSASSSAL..ISFYDSAQNGYLEASRLFTGNDMN..LKISYS.VFHDFGSNDWAVNGIKTHNTSALLANDPHLTTSLP.PIWMGFQLVA.PGMNVIGVTFPGFPGV.ILGHNPYLAWGATNGQIQETYFYAEETSSQ.HPNSYFFN.GSWIKFKIENETIQVKG..SK.....PYFMKIYVAKNGVVVENSSS.............SPIAIDWTGFMPTYEIT.FFLHIDRAQSVSQFRQNL.TQYFKVAIQNWAVADSRGNIGIFPYGLYPI..VERGNPRG........ILPGTG.........QYDWMGFVP.VSQ...LPYLYDPQ.......NGFVFSDNQITV.........SPNYPY..YIGWDYES....GYRADEAYTLLNSTWD.........FNSKDMEMIQLN.VHDFTTDIFLH...............PLLKAMD.........YYGLSGTEAYHSLEAWNGDMLVNSTAAT.........IYYYWIRDFVNDTFMPYMQHYGINESDG.LYQVSFFLGSDD....YYHGPLIEDLVNWTLTDPNINYFNNPVTGQKRNESQVMAEAMNQTLA.................YMTKKYGP...............YSTSWEWGNIHK.........RYLSSFFGINA........MNSAELP.AAGDGNTLNAAYGT.ISDFGPSWRMVVN.....MSHPV.TS..VGIYPGGISENPLSPYYDNTFVAWNNGQYYTLISSKAPEQFFYLY #=GR Q979D7_THEVO/70-856 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... Q9HI83_THEAC/66-851 ATVLVYRQA.DGFIGIASNSTRAVYYEQGYLEAEYRLAQLDFLKRTALGNLSAIAGP...........STLQTDIFMRELQLYN......TAIMERQNLSADN.M....TYIYLKSFVLGINAYIG.N.LT.YSKLPLLFKILNVE........PHRWNVTDVLAVQQLFLWENSAGGLDPIYFNFALQKMPESVI.KAIYPAYPAGVQNPIVPYSLNPKVYDE.......TGDIANLNLNVPYVNLSDSAYATINS.....FYTSAMSGLAEVSSLFTGSYATDQLSINYT.VFHDFGSNDWAVNGIRTSNASAILANDPHLTTSVP.SIWMGFQLVS.PGMNVIGVTFPGFPGI.ILGHNPYVAWGATNGQIQETYFYAEQTSPD.HPGDYLFN.GSWVPFKVENETVLVKG..EK.....PVHIEIEVAKNGVVINDSLG.............VPVAMDWTGYIPTYEIT.FFLNIDRSHSVMQFVQNL.TEYFKVAIQNWAVADSSGNIGIFPYGLYPV..IERGNPRG........ILPGNG.........SYDWTGFVP.YSD...LPYLYDPS.......RGFVFSANQITV.........SPNYPY..YIGWDYES....GYRADQIYTMLNSTYG.........FNYSKMEKIQLT.VHDFTTDIFLK...............PLVKALN.........SDGLSDTPEYSALSSWNGNMDINSTAAT.........IYYFFIRDFVSTVFAPWFSYYGINATDG.MGQTSFFLGTDD....YYHGPLIEDLVNWTMTDQNASFFSNPVTGHKKNETADMLSAYSQAIS.................YLTDKYGQ...............YSSAWEWGNIHK.........RYLSSFFGISA........MNTQEVP.AAGDGNTVNAAYGT.ISDFGPSWRMIVN.....MSDPA.SG..IGIYPGGISENPLSQYYDNTFIDWNNGVYFTLINTEAPSAFFYLY #=GR Q9HI83_THEAC/66-851 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... Q9I2K4_PSEAE/47-796 HEGRIAWDA.AGVPHIRAQSLEDGYFLLGYSHARDRLWQMEFARRYAGGTLSEVFGA...........KTLPMDRFARTLGFRR......TAEGIYANLDAPT.......RVLLQRYSDGINAYLE...LA.PAALPLEFSLVRHER.......PGPWGPVDSLSLHLLYSWTLSANLGMQLQRLALAEHLDLARI.NEVFAPYPGERPP...........................ATRDYASLYRSLHGTPD.............AG...KLLGQLPGSNVEG............IGSNNWVVSASRSATGKPLLANDPHLRLTNP.AAFYLASLKI.PGLSLTGANFAGAPLF.VIGHNQRIAWGYTNTGSHIQDAYLERVDPQ.DPRRYLTP.DGYRPFETRLERIAVRD..GE.....TVSLEVRSTRHGPVISDIYEPAR..LPQAQRDRLVIALAWTGLDRHDKTFPSLLAINRAEGWEQFLD.A.AANFGVPPQNMVYADVEGNIGYVSAGRVPLR.GADDDLHG........LAPSPG....W..ESRYDWVGYVP.ESA...KPRSLNPR.......EGFIATANQRIV.........PPDNAFD.FGHDWVLP.....YRYDRIREWLGGPGQ.........RTLEDSLELQND.EFSSVMASLLP...............KMLEQVS.........DPELRASEAFALLQGWNHQAAADLAAPL.........IAGYWVRAFTRELLQPRIGTQLLASGWNQRNYDG................FLRLILDGQADLRFWCGQEQ.......GCDLKLNQSLRRALD.................ELRAAHGS...............APSGWKWGEAHAALA.....EHVPFHKTPLRA........LFDLKNN.KGGDNFSVNVGRFDYSDPANPFNTRIAATLRMVIDLAD.FDNSRYALSTRNSGLPFDGATD.LNELWARGAYIRIADDAPDATDRQLV #=GR Q9I2K4_PSEAE/47-796 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... PAC2_PSES3/30-767 APVRVQRDG.WGIPHIKASGEADAYRALGFVHAQDRLFQMELTRRKALGRAAEWLGA...........EAAEADILVRRLGMEK......VCRRDFEALGAEA.......KDMLRAYVAGVNAFLA....S.GAPLPIEYGLLGAE........PEPWEPWHSIAVMRRLGLLMGSV......................WFKLWRMLALP..........................VVGAANALKLRYDDGGQDLLCIPPGVEAERLEADLAALRPAVDALLKA..MGGDAS.DAAGGGSNNWAVAPGRTATGRPILAGDPHRVFEIP.GMYAQHHLAC.DRFDMIGLTVPGVPGFPHFAHNGKVAYCVTHAFMDIHDLYLEQFA.E.DGRTARFG.NEFEPVAWRRDRIAVRG..GA.....DREFDIVETRHGPVIAGDPLEG...........AALTLRSVQFAETDLSFDCLTRMPGASTVAQLYD.A.TRGWGLIDHNLVAGDVAGSIGHLVRARVPSR....PRENG........WLPVPG....W..SGEHEWRGWIP.HEA...MPRVIDPP.......GGLIVTANNRVV..........ADDHPD.YLCTDCHP....PYRAERIMERLVASPA.........FAVDDAAAIHAD..TLSPHVGLLR...............ARLEALGI........QGSLPAEELRQTLIAWDGRMDAGSQAAS.........AYNAFRRALTRLVTARSGLEQAIAHPFA.AVPPGVS...............PQGQVWWAVPTLLRNDDAGM......LKGWSWDEALSEALS.................VATQNLT...................GRGWGEEHR...........PRFTHPLSAQFPAWAALLNPVSRP.IGGDGDTVLANGLVPSAGPEATYGALSR...YVFDVGN.WDNSRWVVFHGASGHPASPHYADQNAPWSDCAMVPMLYSWDRIAAEAVT #=GR PAC2_PSES3/30-767 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... Q9AK68_STRCO/1-782 MSAETYRDA.WGIPHLRADTPHELARAQGRVTARDRAWQLEVERHRAQGTSASFLGP...........EALSWDRLARRARLAD......TARRCFTALERKDPE....TAAWVRAYTDGVNEGLTEP.GH.PNPAP.EFARTGLA........PGRWDPWTPLGV.....WLATHI.............L.........FAGFPAKLWR................................EHISTHLG...P..................EAVALFAADGPGT............AGSNGWLVSGERTTTGHALIAGDPHRFIEDP.GVYQQVHLSC.PEFDVVGLAVPGVPGVAHFGHTGTVAWAITNAMADYQDLYRERLRRTGAGVEALGPDGIWHRAARHTERIDVAG..ED.....TVEVEIIETDRGPVIAGGPEGLD..DG....TPAALSLRYPPRVTADLGFGALLPLLRARRVADVDR.A.LDAWAEPVNVVQAADTEGGLLHRVAGRVPVR....PAANG........LRPVPA....W..EPGHEWTGWH........TPPRAGLT.......DGVAVMANQR...........GPATPL...GVEFAPP.....HRADRITALLAGKEH.........WSAADMPAIHTDTHLGSAAPLLTHLAALPSEAALASEAALTPEAALT.......PEAALASEAALASEAAPGPKAAPDPEAAPTPEAAPDPETAPTPEAAPTPEATPTAAPPEAPPTPLTPLTPLTPEAAALRDRILAWDRRMDADSTDAAAYAAVRAAVVRRLAAHPVLAPASVPPAYPEVLLPWLALVPRLGHALEHLLRAEDLYGIDRAAAVRAALEEVAASPPSGTWGDTHR.........LAPWRALPDTA........TAPGGEPGLSGDHDCVLCTSPVPGLTDRAARGPAAR...YVWDLAD.RANSRWVVPHGASGLPGSPHHHDQQPLWLGGELAPVVTDFDRLTKESDD #=GR Q9AK68_STRCO/1-782 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... QUIP_PSEAE/54-838 QNVSIRRNA.LGMPLIETGTFHDALFALGYVHASDRLSQMVSLRLLAQGRLAEMVGP...........GALEIDRFMRTVNLRQ......AAEIQYRNASPRL.......QRFFEVYARGVNAYLY...RY.RDKLPMDLAQSGYR........PEYWKPEDSALVFALLNFGLAVNLQEEIASLTLAQKVGSDKL.AWLTPTYPDENLP..........................FDEAEKLKGLRLDGQVPG.............LAGVEGAARQVAALSMLG...........VAASNNWAIAPQRSRSGKSLMANDTHLPLSMP.SVWNYVQIRS.PKYQAAGVSIAGLPGV.VAGFNGKLAWGMTMVLGDNQDLYLEQLRRQ.GNRLYYLADGKWQPTRERQETFFIKG..QR.....PIREVIHETRHGPLLNSALGERKNILQPLPLKSGYGLAYRSIQQEADKTLDGFFDLSRAKTIEQAFD.A.TREIRAMPLNIVFAD.EKHIGWQVTGRYPN....RKEGRG........LLPSPG....W..DGRYDWDGYAD.PIL...HPSDQDPQ.......QGWLGTANHRTV.........QPGYGAQ.LSNSWYYP.....ERAERIAQLAGASKS.........HDTQSMIRMQYDQTSLFVAKLQAMFDN.......PGMALPLRQAIDAL.....PEAQRSRAREAYDRLMAFDGKLTASSSDAA.........LYGAFLHESARQIFLDELGPEDGPAWKAFVETANLS............YSAQADHLLGRDDSPFWDDTRTP...QKEDKPAILARSLAAAVE.................FCEQRLGS...............ERKAWQWGKLHTYEWQSDSSKMAPYLGAGERAGLGAIKGYLDRGPYP.AGGDHTTLDVSAYG.WGQDFDTWLIPAMR..LIVDFGQ.SEPMIGVNSSGQSGNPASPHYADGIDAWLKGRYVSFPFQPQNLDRVYGN #=GR QUIP_PSEAE/54-838 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... Q9I6I6_PSEAE/41-787 APVDVRYDE.RGVPHLYAQNQTDLYRALGYVHAQDRLFQMEMLRRLARGELAEVLGP...........KLVDTDRLFRTLRIRD.....HAAEYSARQDKQSQ......PWKVLEAYLDGVNQFQE......NNPAPLEFDLLGIP........RRPFTPEDTLSIAGYMAYSFAAAFRTEPVLTYIRDELGSDYLRIFDLDWHPQGVLT............P..............SGALGAGDWKDLGALAR................LSQQALEDAGLPQFE.............GSNAWVVAGSRTASGKPLLAGDPHIRFAAP.AVWYEAQLSA.PGFELYGHHQALNPFA.SLGHNRAFGWSLTMFQNDDLDLVAEKVNPD.NPNQVWYQ.GEWVDLQSEEQEIAVKG..AA.....PVKLTLRRSPHGPIVNDALGASS........GKTPIAMWWAFLETENPVLDAFYQLNRADTLAKARA.A.ASKIHSPGLNLVWANAAGDIGWWASAALPK....RPEGVN.......PSFILDGS......KGEADKSGFYP.FAD...NPQEENPA.......RGYIVSANFQPV.........PANGRPI.PGYYNLAD......RGQWLDTQLADRGT........KWNLDNSRALQLGNRTGYAPRLLAP................LLPVLRE.......VVDDAEGKRLVEQLAAWNGDYPVDSTAAT.........LFNQLLFQIAEGALHDELGDAFFDSLIATRAIDS.................ALPRLAGDADSPWWDDRRTE...RRETRADIVRTAWNASLA.................HLRGTLGN...............DPSGWLWGKAHT.........LTHEHALGQQALLR...RLLNVGPFAAPGTHEVPNNLSAKIGPAPWAVTYGPSTR...RLVDFAD.PTHSLGINPVGQSGVPFDGHYDDQAEAYIEGHYLPQHYEENEVKANSKG #=GR Q9I6I6_PSEAE/41-787 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... Q9A9G3_CAUCR/35-682 YDVRIRRDE.WGVPHILGRTDADAAFGLGYAQSEDDFDTLQDVVLATRGVLARDKGA...........GAAPTDYVVSLLEVWP......TVDKHYAELPAEL.......RAIMEAYADGVSLYVA........KHP.EKAKPGLL........PVTGKDVAAGFIFKQPFFYGLDG...........................ELRRIT................................................................APATKGPPPK..............GSNGLATAPSRSVDGATRLLVNSHQPYTGP.VAWYEAVVQSGQGWHVAGGFFPGSPFM.LHGHNATLGWANTVSKPDLVDVYRLTINPA.NKNQYRLD.GQWKDFDKRYVTLRVKL..LG.PIVLPVRKAVLRSAHGPVLETDHG..............VFAIRYAGMGEWRQPL.QYWRLNRARTVEDWRA.A.IATHAIPSLNYVYADAAGNIGFVHNGQYPNR.RAKADWGG........VLPGDR........SDLIWQGYLP.VEN...SPQLWNPK.......SGLVFNSNNTP.............FEAS.EAADNLKP........ADFPASMGLQAN.........MTNRAWRALETYGADRALTDASFR..............AHKFDVAF.........SDRSSVMAMVGEVLAVDPKGDADLAEAQR........ILRAWDKRADRTNRGAALAALMSQPILFAN..........................TNGDPAPAP.................IDSLRAAIKT..................LKTHFG.................RLDPEWGEVNR........IRRGTVDLPIDG.........AADTFRSVWGKPQKDGTTTAD..GGDTFVMFVTWD......KAGA.LRSESIHQFGSATLDAASPHYADQTPLFVAMKTKPVRFTEDQLQGHIKV #=GR Q9A9G3_CAUCR/35-682 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... Q9A972_CAUCR/34-719 AKVEITRDT.WGIAHIHGKTDADAVFGMAYAQAEDDFNRVEANFMTSLGRTAEAEGE...........KAIWADLRQKLFIDPA......VLKADYAKSPAWL.......KALMNAWADGLNYYLQ......T..HPTVKPRVIQR........FEPWMALSFSEGSIGGDIERVALT........................QLEAFYGK....................................RQLAMTAD...................EKGLLFKEPTG...............SNGIAIAPKLTLDGAAMLLINPHTSFFFR....SEMQVSSNEGLNAYGATTWGQFFI.YQGFNAKAGWMHTSSGVDVVDEFIETIVEKDGQRFYKYG.DQLRPLKTEVITAPYRT..ADG.AMAERKFTVFKTHRGPIVREENG...............KWISIALMNKPVAALQQSFLRTKATDYAAFMK.V.AELKANSSNNTLFASAKGEIAYLHPQFIPIR...DDRFDY........TKPVDG....A..DPATDWKGLHA.LKD...APHVLNPP.......NGWTFNTNNWPY.........TAAGPYS.PKLADFPK.....YMDTFGENPRGLHAE.........LVLKDVKNLTLG...GLIEKAYDP...............YLTAFAR..........LIPTLETAYAATSDSDPIKAKVAAQVA.........ALAAWDRKWSTRSTETSLAVFWGETMWAKAAP....................AAKAQGLNTYDYMADKLS........AADKLAALAEASDR..................LTADFG.................SWKTPWGEINR..FQRNDGAIVQTFDDTKPS........LPVGFTSAQWGSLASFGAKRWPGTKKYYGTLGNSFVA...VVQFGD.KVRARAISAGGESGDPASPHFNDQAPRYAIGNLRDVYFYPEDVKKHAVR #=GR Q9A972_CAUCR/34-719 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... Q9RYQ4_DEIRA/36-778 YQVQIQRTA.HGIPHIQASDLGGIGYGVGYSYAQDNLCLLADQVMTVRGERSKFLGAEGKTVVGFQPVNNLDSDVFFKTVIEPG......RLQAGYRDQPQIL........ALMRGYVAGVNRYLR....D.TPPEQWPSACRNADW.......VRPLTELDVMRLGEEKAIQASAG....................AMVSAITSARPPQ.................................AGASTAAPRPD................LAAFNRQYRFNDLP.............IGSNGWAFGSEATTNGRGLLLGNPHFPWETS.NRFYQLHLTLPGQFDVMGASLGGMPVV.NIGFNQDVAWTHTVSTDKRFTLAALTLVPG.DPLSYVKD.GQQRRLQRRTAVIEVKT..ANG..PRLHTRTVYFTPEGPLVNLPAAG.......LTWTPQYAFALRDANRNNTRMLATWLGFAGAKSVRDIRA.S.LNVQGIPWVNTIAADRAGSALYADISSSPN..VSAAQQQACTPPPLAPLFPAAGLAVLDGSHSACDWKTDP..ASR...VPGLRAPDKMPVLIRQDFVANSNNSAWLAN....PAAPQTGLDPLVGEVNAPQ...SPRTRMGLLEIGRRLSGTD.....GLPGRTFDIPTLQATLLRESNLTGEM..............YAADAAKLC.....QSAGGAELQPACNALAAWDRRSSQESRGAA............LWREFWRRARAIPNVYAVPFDPADP...............................VNTPRGLNTADP......AAQTALLGALREAAA..................ALTAAG................IPFDAPLGEVQG........VVRGGDFISLPG..........GAEFE...GVLDKIDFNPLAPGGYRGVVGNASSY..IQTVGFTDSGVQAEAVLTYSQSSNPESPYFSDQTRLFSRSEWVKLPFTQPEIEADPTR #=GR Q9RYQ4_DEIRA/36-778 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... AAC_ACTUT/37-776 YAALIRRAS.YGVPHITADDFGSLGFGVGYVQAEDNICVIAESVVTANGERSRWFGAT........GPDDADVRTTSSTQAIDDR.....VAERLLEGPRDGVRAPCDDVRDQMRGFVAGYNHFLR...RT.GVHRLTDPACRGKAW.......VRPLSEIDLWRTSWDSMVRAGSG....................ALLDGIVAATPPT................................AAGPASAPEAPD................AAAIAAALDGTSAG.............IGSNAYGLGAQATVNGSGMVLANPHFPWQGA.ERFYRMHLKVPGRYDVEGAALIGDPII.EIGHNRTVAWSHTVSTARRFVWHRLSLVPG.DPTSYYVD.GRPERMRARTVTVQTGS..G......PVSRTFHDTRYGPVAVVPGTFDWT........PATAYAITDVNAGNNRAFDGWLRMGQAKDVRALKAVL.DRHQFLPWVNVIAADARGEALYGDHSVVPR..VTGALAAACIPAPFQPLYASSGQ...AVLDGSRSDCALGADPDAA..VPGILGPASLPVRFRDDYVTNSNDSHWLA.......SPAAPLEGFPRILGNERTPRSLRTRLGLDQIQQRLAGTDGLPGKGFTTARLWQVMFG.NRMHGAELVRD...............DLVALCRRQPTATASNGAIVDLTAACTALSRFDERADLDSRGAH.........LFTEFLAGGIRFADTFEVT....DPVR................................TPAPFWNTTDP...........RVRTALADACN...................GSPAS.................PSTRSVGDIHTD........SRGERRIPIHG...........GRGE..AGTFNVITNPLVPGVGYPQVVHGTSFV...MAVELGPHGPSGRQILTYAQSTNPNSPWYADQTVLYSRKGWDTIKYTEAQIAADPNL #=GR AAC_ACTUT/37-776 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... PVDQ_PSEAE/31-755 LAADIRWTA.YGVPHIRAKDERGLGYGIGYAYARDNACLLAEEIVTARGERARYFGSEGKS...SAELDNLPSDIFYAWLNQPE......ALQAFWQAQTPAV.......RQLLEGYAAGFNRFLR.......EADGKTTSCLGQPW.......LRAIATDDLLRLTRRLLVEGGVG....................QFADALVAAAPPG.................................AEKVALSGEQA.................FQVAEQRRQRFRLE............RGSNAIAVGSERSADGKGMLLANPHFPWNGA.MRFYQMHLTIPGRLDVMGASLPGLPVV.NIGFSRHLAWTHTVDTSSHFTLYRLALDPK.DPRRYLVD.GRSLPLEEKSVAIEVRG..ADG.KLSRVEHKVYQSIYGPLVVWPGKLDWN........RSEAYALRDANLENTRVLQQWYSINQASDVADLRRRV.EALQGIPWVNTLAADEQGNALYMNQSVVPYLKP.ELIPACAIPQLVAEGLPALQG...Q..DSRCAWSRDPAAAQAG.ITPAAQLPVLL....RRDFVQNSNDSAWLT.......NPASPLQGFSPLVSQEKP.IGPRARYALSRLQGKQP.........LEAKTLEEMVTA.NHVFSADQVLP...............DLLRLCRD.......NQGEKSLARACAALAQWDRGANLDSGSG...........FVYFQRFMQRFAELDGAWKEPFDAQRP.............................LDTPQGIALDRPQ........VATQVRQALADAAA..................EVEKSG................IPDGARWGDLQVS........TRGQERIAIPG.........GDGHFGVYNAIQSVRKGDHLEVVGGTSYIQLVTFP........EE.GPKARGLLAFSQSSDPRSPHYRDQTELFSRQQWQTLPFSDRQIDADPQL #=GR PVDQ_PSEAE/31-755 SS EEEEEEEEG.GGEEEEE-SSHHHHHHHHHHHHHHHHHHHHHHHHHHHTT-HHHHH-TTSB-...TTS-BHHHHHHHHHHHT-HH......HHHHHHHTS-HHH.......HHHHHHHHHHHHHHHH.......H--STT-TTTT-TT.......-----HHHHHHHHHHHHGGGTGG....................GGHHHHHH-----.................................S--XXXXXXXX.................XXXXXXXXXXXXXX............XXXEEEEEXTTTBTTSSXEEEEEXEEESSGG.GXXEEEEEEETTTEEEEEEEXTTXSSX.SEEEXSSEEEEEEEXSSXSEEEEEEEEETT.EEEEEEET.TEEEEXEEEEEEEEEEX..TTS.XEEEEEEEEEEETTEEEEXBTTTBXXX........SSEEEEEEEGGGGXTTHHHHHHHHHTXXSHHHHHHHH.HHHXXXXSEEEEEEETTXXEEEEXXSXXBXXXG.GGHHHHBXHHHHTTTXXEEET...T..XGGGSXXXXTTSSSTT.BXXGGGSXEEE....ESSEEEESSSXSTTS.......STTSXXXSXXTTTXXXXX.XXHHHHHHHHHHSSSSX.........BXHHHHHHHHHT.XBBTHHHHHHH...............HHHHHHHH.......TTTXCCCHHHHHHHHHXXSBXSTTXBTH...........HHHHHHHHHHHTTSSSXEEEXXXTTST.............................TTXSEEEXTTSHH........HHHHHHHHHHHHHH..................HHHHST................XXTTXBHHHHEEE........EETTEEEEXXX.........BXGGGTBSSBEEEEEETTEEEEEEEEXEEEEEEXX........TT.SXEEEEEETTXSXSXTTSTTSSHHHHHHHTTXXEEEXXSHHHHHHXTTX #=GR PVDQ_PSEAE/31-755 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... O86089_9PROT/45-712 RSNEILWDG.YGVPHIYGVDAPSAFYGYGWAQARSHGDNILRLYGEARGKGAEYWGP...........DYEQTTVWLLTNGVPER......AQQWYAQQSPDF.......RANLDAFAAGINAYAQ......QNPDDISPDVRQVL........PVSGADVVAHAHR.LMNFLYVAS...........................PGRTLG......................................EG.........................D..PPDLADQ.............GSNSWAVAPGKTANGNALLLQNPHLSWTTDYFTYYEAHLVT.PDFEIYGATQIGLPVI.RFAFNQRMGITNTVNGMVGATNYRLTLQ....DGGYLYD.GQVRPFERRQASYRLRQ..ADG.TTVDKPLEIRSSVHGPVFERADG.............TAVAVRVAGLDRPGMLE.QYFDMITADSFDDYEA.A.LARMQVPTFNIVYADREGTINYSFNGVAPKR...AEGDIAFWQG....LVPGDS........SRYLWTETHP.LDD...LPRVTNPP.......GGFVQNSNDPPWTPTWPVTYTPKDFPSY.LAPQTPHS.....LRAQQSVRLMSENDD.........LTLERFMALQLS.HRAVMADRTLP...............DLIPAALI........DPDPEVQAAARLLAAWDREFTSDSRAAL.........LFEEWARLFAGQNFAGQAG...FATPWS...........................LDKPVSTPYGVRDPK..........AAVDQLRTAIAN..................TKRKYG.................AIDRPFGDASR..........MILNDVNVPG..........AAGYG.NLGSFRVFTWSDPDENGVRTPVHGETWV...AMIEFST.PVRAYGLMSYGNSRQPGTTHYSDQIERVSRADFRELLLRREQVEAAVQE #=GR O86089_9PROT/45-712 SS SSXEEEEXT.TSXEEEEXSSHHHHHHHHHHHHHHHHHHHHHHHHHHHTTXHHHHHXG...........GGHHHHHHHHHTTHHHH......HHHHHHTSXHHH.......HHHHHHHHHHHHHHHH......HXSSSSXGGGTTTX........SXXHHHHHHHHHH.HHHHTTTSX...........................HHHHHX......................................XX.........................X..XXXXXXX.............X-EEEEE-GGGBSSS--EEEEE-EEESS-GGG-EEEEEEE-.SS-EEEEEEETT-SS-.SEEE-SSEEEEEE------EEEEE-EEE....TTEEEET.TEEEE-EEEEEEEEEE-..TTS.-EEEEEEEEEE-SSSBEEE-TTS.............-EEEEEETTTT-TTHHH.HHHHHHT-SSHHHHHH.H.HTT--S-S-EEEEEETTS-EEEEE-S--B--...SS--HHHHHS....EEESS-........GGG----B--.GGG...S-EEES-T.......TSEEEESSS-TT-SSSS-S--GGGS-TT.SS------.....HHHHHHHHHHHT--S.........B-HHHHHHHHT-.BB-HHHHHHHH...............HHHHHHHT........SS-HHHHHHHHHHHCS-SB--TT-SSHH.........HHHHHHHHHSTTTS---TT...EEE---...........................TTSTTT-SEEES-HH..........HHHHHHHHHHHH..................HHHHHS.................STT--HHHHBE..........EEETTEEEE-..........--B-G.GGTBSSBEEE----TTS-B-EEEEE-EE...EEEE--S.S-EEEEEETT-S--STT-SSSSSSHHHHHTT--EE---SHHHHHHHECE #=GR O86089_9PROT/45-712 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... Q55592_SYNY3/35-700 GKTEIFWDS.WGVPHIFAANETKLMEAFGWAQARGHGDLLLTLYGEARGKGAEYWGI...........DYLDNDQYVHTMNIPR......RSEVWLNAQTPAM.......RRDLESFAQGINNYFQ......QHPDFSQPSLRQVL........PITAQDVVAHVQR.LLLFEFVTN...........................PQAVAS...............................................................LAGQIPEANVP.............IASNAWAIAPKQTESGHGLLLINPHLPWGGQ.FRLTEAQLVA.PGMDLTGAAFVGTPVP.AMGFNNDLGWSLTVNYPHNVGKYALTLA....EGGYEWD.GEVKSFDRRNNQVKILQ..GNG.SYQTLQWEALESVTGIVVAQRGG.............NAYTLKIPGLDRSGAIS.QFLHMGKAKTLEQFEA.A.WQKQQIPMFNVLYSDRQGNIFYLYNTLTPIR...EGSWQDWDR.....LQPINR.........SADLNSDYYIYEQ...LPKLTNPA.......SGWLQNSNDPPWTSTFPPELDAADYPPS.LAAPDLSFAP.SLLRTQRSIKLLKNNSS.........LTFEQFKQKVFD.SQMELGDRIVP...............LLVSAAKV........LANPIGIEAAEVLQAWDKQANPDSRGAV.........LFMLWALTIGADKVLGGQWN..PADPLN.................................TPSGMADIN..........KFMAVLEGVAAQ..................VKFLYDD.................LAISWGEVVQ..........MQVGNFTAPA...........NGAPSNLGSFRVLALSTIA.NQRFQAVAGDSYLS...LVEFAD.RPRGQSILVYGNASQPDSPHNGDQLELYSKNQLRPVWRSPREIKAHLEK #=GR Q55592_SYNY3/35-700 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... Q9S258_STRCO/103-886 DDVTIVRDKKTGVPHITGTTRYGTEFGAGYAAAQDRLWLMDLFRHVGRGQLTPFAGGA........PANQGLEQQFWRSAPYTEA.....DLEAQIESAAAKAGERGELALADVDAYVAGVNAYIDAS..DKGRYFPGEYVLTGHKDAITNAGTIEHFKRSDLIALASVIGSLFGAGGGGEVNNALSLLAAQEKYGVAEGTEVWESFRQRNDPEAVLTQQDGS........FPYLPTPDDPQGLALPDAGSVEP..........EPLVYDRTGSAGAAGATGASAKSAEAAVTSARRGMSNALVVSGEHTASGHPVAVFGPQTGYFAP.QLLMLQEIQG.PGISARGASFAGLSMYVELGRGQDYAWSATTSGQDIIDTYAVELCQD..DYHYLYR.GTCTPMEKVERHNAWRPTVADSTAAGSYTMRVWRTKYGPVESRATVGGK.........KVAYTTLRSSYLHEADSIIGFQMLNDPDYLNSPERFQGAVQHINYTFNWFYAD.SEHTAYYNSGDNPVR...ADGVDA........EFPVWAR.......SAYEWQGWDPADNTARYTGASAHPQS....VDQDYYISWNNKQ..........ARDYPAASWGNGSVHRG...NLLDDRVKKLVDGGGV.........TRTALVKAMAEAALADLRAEDVLP...............DLLKVVESA......PVTDPAAKTAVAGLKAWLSAGGLRTETSA.........GSKKYAHADATRTLDAWWPLLVKAEFEP..............................GLGTDLYTALTR.........NLPVDESPSAAHG.................PTGAHAGS................AFQYGWWSYVD..........KDIRSVLGES...........VKGP..LARPYCGGGDLAACRDSLVSTLKEAAG............RTAAQVYPGDDNCSAGDQWCADSVIHRTLGGIKHGGISWQNRPTYQQV #=GR Q9S258_STRCO/103-886 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... PAC_ARTVI/30-794 EGVKVVRDN.FGVPHLYAKNKKDLYEAYGYVMAKDRLFQLEMFRRGNEGTVSEIFGE...........DYLSKDEQSRRDGYSN.....KEIKKMIDGLDRQP.......RELIAKFAEGISRYVNEALKDPDDKLSKEFHEYQFL........PQKWTSTDVVRVYMVSMTYLWIITR.ELKNAEILAKLEHEYGTEVSRKMFDDLVWKNDP..................SAPTSIVSEGKPKRESSSQSLQK............LSSAVIKASEKVGKERENFVQSSEELGLPLKIGSNAAIVGSEKSATGNALLFSGPQVGFVAP.GFLYEVGLHA.PGFDMEGSGFIGYPFI.MFGANNHFALSATAGYGNVTDIFEEKLNTK.NSSQYLYK.GKWRDMEKRKESFTVKG..DNGE.KKTVEKIYYRTVHGPVISRDETN...........KVAYSKYVSFRGTEAQSMSAYMKANWAKNLKEFEN...AASEYTMSLNWYYADKKGDIAYYHVGRYPVR....NNKID.......ERIPTPG.......TGEYEWKGFIP.FKE...NPHVINPK.......NGYVVNWNNKPS.........KEWVNGE.YSYYWGED.....NRVQQYINGMEARGK.........VTLEDINEINYTASFAQLRANLFKP..............LLIDVLDKN......KSTNGNYTYLIEKLEEWNNLKEDENKDGYYD..AGIAAFFDEWWNNLHDKLFMDELGDFYGITKEITDHRYG................ASLAYKNISKESTNYKWVNVD.......QEKIIMESTNEVLA.................KLQSEKG.................LKAEKWRMPIK............TMTFGEKS..........LIGIP..HGYGSMTPIIEMNRGSENHYIEMTPKG.....PSGFN.ITPPGQIGFVKKDG.TISDHYDDQLVMFAEWKFKPYLFNKKDIYKAATN #=GR PAC_ARTVI/30-794 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... O34142_ALCFA/29-806 QSVEVMRDS.YGVPHVFADSHYGLYYGYGYAVAQDRLFQMDMARRSFVGTTAAVLGPGE.......QDAYVKYDMQVRQNFTPA......SIQRQIAALSKDE.......RDIFRGYADGYNAYLEQVRRR.PELLPKEYVDFDFQ........PEPLTDFDVVMIWVGSMANRFSDTNLEVTALAMRQSLEKQHGPERGRALFDELLWIN...........DT.......TAPTTVPAPAAEHKPQAQAGTQD.............LAHVSSPVLATELERQDKHWGGRGP.DFAPKASNLWSTRPERVQEGSTVLINGPQFGWYNP.AYTYGIGLHG.AGFDVVGNTPFAYPIV.LFGTNSEIAWGATAGPQDVVDIYQEKLNPS.RADQYWFN.NAWRTMEQRKERIQVRG..QA.....DREMTIWRTVHGPVMQFDYDQG...........AAYSKKRSWDGYEVQSLLAWLNVAKARNWTEFLD...QASKMAISINWYYADKHGNIGYVSPAFLPQ....RPADQD.......IRVPAKG.......DGSMEWLGIKS.FDA...IPKAYNPP.......QGYLVNWNNKP..........APDKTNT.DTYYWTYG.....DRMNELVSQYQQKDL.........FSVQEIWEFNQKASYSDVNWRYFR...............PHLEKLAQQ......LPADDSSKAALTMLLAWDGMEQDQGGQNAG....PARVLFKTWLEEMYKQVLMPVVPESHRAMYSQTGFATQQG..............PNPGSINLSMGTKVLLRALVL...EAHPDPKRVNVFGERSSQE................IMHTALQN.............AQARLSQEQGAQMAR.......WTMPTSVHRFSD........KNFTGTPQTMPGNTFAFTGYQNRGTENNRVVFDAKG.....VEFCD.AMPPGQSGFTDRNG.VRSPHYEDQLKLYENFECKTMDVTHADIRRNAQS #=GR O34142_ALCFA/29-806 SS EEEEEEEET.TS-EEEE-SSHHHHHHHHHHHHHHH-CHHHHHHHHHHHT-TCCCC-S-T.......TTCHHHHHHHHHHC--HH......HHHHHHHTS-HHH.......HHHHHHHHHHHHHHHCCCCC-.GGGSBHHHHHHT--........-----HHHHHHHHHHHSTTTSSS---CHHHHHHHHHHCCCTCCCCCCCCHHHHS-SS...........--.......SSS-BSS-S--XXXXXXXXXXXX.............XXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXEEEEEXTTTBTTXXEEEEEEXXSXXBSS.XSEEEEEEEE.TTEEEEEEEETTXSSX.SEEEXSSEEEEEEEXXSXXEEEEEEEEXSS.XTTEEEXS.SSEEEXEEEEEEEXXTT..SX.....XEEEEEEEXSSSBEEEEETTTT...........EEEEEEETTTTXHHHHHHHHHCCCTXXSHHHHHH...HHTTXXSXEEEEEEETTSXEEEEXXXXXEE....XXTTXX.......TTSXEEC.......TTTSXXXEEXX.GGG...SXEEESXT.......TSEEEECSXBS..........STTXXXX.SSXXXXSX.....XTTHHHHTTTTTXSS.........BXHHHHHTCCHHHHCCXSSCCCCC...............HHHHHHHCC......SXTTSSSHCCCTTCCCXXSBXXECTTCESS....SHHHHHHHHHHHHHHCTCCCCSXSTTCHHHCXXXSXXSSS..............XXXSSXXXXHHHHHHHHHHCC...CCSXXTTSXXSSTTSXHHH................HHHHHHHH.............HHHHHHCTSXSXCCC.......XXXBXXEEEEBS........BXTTSXBSSSTTXXEEECSXXXSXSSEEEEEEETTE.....EEEEE.EXSSXSXXXBBTTS.XBXTTSSTTCHHHHTTXXEEEXXSHHHHCCCEEE #=GR O34142_ALCFA/29-806 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... PAC_KLUCI/31-836 TEVKIVRDE.YGMPHIYADDTYRLFYGYGYVVAQDRLFQMEMARRSTQGTVSEVLGK...........AFVSFDKDIRQNYWPD......SIRAQIASLSAED.......KSILQGYADGMNAWIDKVNASPDKLLPQQFSTFGFK........PKHWEPFDVAMIFVGTMANRFSDSTSEIDNLALLTAVKDKYGNDEGMAVFNQLKWLVNPSAPTTIAARESSYPLKFDLQNTQTAALLVPRYDQPAPMLDRPAKG...TDGALLAVTAIKNRETIAAQFANG...ANGL.AGYPTTSNMWVIGKNKAQDAKAIMVNGPQFGWYAP.AYTYGIGLHG.AGYDVTGNTPFAYPGL.VFGHNGTISWGSTAGFGDDVDIFAEKLSAE.KPGYYQHN.GEWVKMLSRKETIAVKD..GQ.....PETFTVWRTLDGNVIKTDTR...........TQTAYAKARAWAGKEVASLLAWTHQMKAKNWPEWTQ...QAAKQALTINWYYADVNGNIGYVHTGAYPDR...QPGHDP........RLPVPD........GKWDWKGLLS.FDL...NPKVYNPQ.......SGYIANWNNSP..........QKDYPAS.DLFAFLWGG...ADRVTEIDTILDKQPR.........FTADQAWDVIRQTSLRDLLRLFLP...............ALKDATAN.......LAENDPRRQLVDKLASWDGENLVNDDGKTYQ..QPGSAILNAWLTSMLKRTVVAAVPAPFGKWYSASGYETTQD..............GPTGSLNISVGAKILYEALQG...DKSPIPQAVDLFGGKPEQE................VILAALDD.............AWQTLSKRYGNDVTG.......WKTPAMALTFRAN........NFFGVPQAAAKEARHQAEYQNRGTENDMIVFSPTSGN.RPVLAWD.VVAPGQSGFIAPDG.KADKHYDDQLKMYESFGRKSLWLTPQDVDEHKES #=GR PAC_KLUCI/31-836 pAS ...........................................................................................................................................................................................................................................................................................................*......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... #=GC SS_cons EEEEEEEET.TSEEEEE-SSHHHHHHHHHHHHHHHHHHHHHHHHHHHTT-HHHHH-CTTB....TTTTCHHHHHHHHHHCTHHHH.....HHHHHHHTS-HHH.......HHHHHHHHHHHHHHHHCCCC-.HHCSSCCHCCTTTTT.......S--HHHHHHHHHHHHHHCTTTSC---CHHHHHHHHHHCCCTCCCCCCCCHHHHCHSS...........--.......SSS-BSS-S--XSXXXXXXXXXX.............XXXXXXXXXXXXXXXXXXXXXXXXX.XXXXXXXEEEEEXTTTBTTSSEEEEEEXEEESSCGGGSEEEEEEEETTTEEEEEEEETTXSSX.SEEEXSSEEEEEEEXSSXSEEEEEEEEETT.ETTEEEET.TEEEEXEEEEEEEEEET..TTS..EEEEEEEEEEESSSBEEEETTTCT..........SCEEEEEETTTTGCTHHHHHHHHHHTXSSHHHHHHHH.HHTTXSSSEEEEEEETTSXEEEEEXSXXBE..G.CCCCHHCHHCHHTTTCEEECT...T..TGGGSXXEETTSGGGT.BSXEEESXTEE....ETSEEEESSSBSTTSSSS.S..STTSXTTSSSTTTXSX.....HHHHHHHHHHCTSSS.........BXHHHHHHHHHCHCBCCHHHHHHH...............HHHHHHHCC......TTTTCCCHHHHHHHHCSXSBXSTTTCCHCS....SHHHHHHHHHHHHHHCTCCCCTCCCTCCCCCTXXSXXSSS..............XXXSSTTTTCCCCECCCCHHC...CCSXHCHHHHHHHHHHHHH................HHHHHHCH.............HHHCTTCCHHHHCEC.......XEECCCEEEEES........BBTCCGCCSSTCCCEEECTEEECCSCEEEEEEECCE...EEEEECC.SXEEEEEETTBSTSSTTSTTSSCCHHHHHTTXXEEEXXSHHHHHHCECE #=GC seq_cons tsVcIh+Du.aGlPHIhAssptslhauhGYspApDRLhpl-hh+tpApGphuchhGs...........stlssDhhh+phthsp......ssctphpshssp........tshlcuYusGlNtYlp....t.tp.hPh-ashhshp........Pc.asshDshtlt.hhhhphsus.............h......t.hhshasshh.t..................................h.tshs.hts................h.thstthsspsts.............hGSNsWsluup+TssGpslLhssPHhsatsP.shahphpLps.suaclhGsohsGhPhl.hhGaNsplAWuhTsstschhDhYt.pls.p.ssspYhas.Gpapshcp+ppsltV+s..sp.....shphplhcThcGPVlspsss.............sshshthsshtpsspsh.sahphscAcslpphpp.s.tpthtssshNhhaADtpGsIuahssuhhPh....pss.ps........hhPssG........uph-WpGhhs.hpt...hPphhsPs.......pGalhsuNppsh.........ssshsht.hssthhts.....hRspphhphlstpss.........hshcshhplphs.stshhschhh.................llcshp.........ssssssppAhstLtuWstphsssopuAs.........lathahcthsppshhsthst.hhsshhs.h.......................s.h.hssssshh.tttp.........sthlspuhspuhs..................hpsphG.................shshpWGchpp.........hh.hpshshpu.........sssshs.hhGshsshsssths.sstsssshtsshs.....hphss.hspsttlhssupSusPtSPHYsDQh.haspspahslhhs.pplptphpt //