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6  structures 133  species 0  interactions 326  sequences 3  architectures

Family: TCL1_MTCP1 (PF01840)

Summary: TCL1/MTCP1 family

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This is the Wikipedia entry entitled "TCL1 MTCP1 protein domain". More...

TCL1 MTCP1 protein domain Edit Wikipedia article

PDB 1jsg EBI.jpg
crystal structure of p14tcl1, an oncogene product involved in t-cell prolymphocytic leukemia, reveals a novel b-barrel topology
Symbol TCL1_MTCP1
Pfam PF01840
InterPro IPR004832
SCOP 1jsg

In molecular biology, TCL-1/MTCP-1 is a protein domain found in proteins encoded for by two related protooncogenes, other words by genes that help promote cancer. They are, T-cell leukemia/lymphoma protein 1A TCL1A encoded by oncogene TCL-1 SWISSPROT and Protein p13 MTCP-1 encoded by MTCP-1 SWISSPROT.

These are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28.[1]


Enhances the phosphorylation and activation of Akt. Once Akt is activated this will in turn trigger cell survival. Further more it helps to stabilise mitochondrial membrane potential.[2][3]


This protein exists as a homodimer. It interacts with AKT1, AKT2 and AKT3 via the PH protein domain. It interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.


  1. ^ Fu ZQ, Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Rothstein JL, Croce CM, Weber IT, Harrison RW (March 1998). "Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3413–8. doi:10.1073/pnas.95.7.3413. PMC 19850Freely accessible. PMID 9520380. 
  2. ^ Pekarsky Y, Koval A, Hallas C, Bichi R, Tresini M, Malstrom S, et al. (2000). "Tcl1 enhances Akt kinase activity and mediates its nuclear translocation". Proc Natl Acad Sci U S A. 97 (7): 3028–33. doi:10.1073/pnas.040557697. PMC 16186Freely accessible. PMID 10716693. 
  3. ^ Laine J, Künstle G, Obata T, Sha M, Noguchi M (2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986. 

This article incorporates text from the public domain Pfam and InterPro IPR004832

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

TCL1/MTCP1 family Provide feedback

Two related oncogenes, TCL-1 P56279 and MTCP-1 P56278 are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28 [1]. This family contains two repeated motifs that form a single globular domain [1].

Literature references

  1. Fu ZQ, Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Rothstein JL, Croce CM, Weber IT, Harrison RW; , Proc Natl Acad Sci U S A 1998;95:3413-3418.: Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies. PUBMED:9520380 EPMC:9520380

  2. Hoh F, Yang YS, Guignard L, Padilla A, Stern MH, Lhoste JM, van Tilbeurgh H; , Structure 1998;6:147-155.: Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology. PUBMED:9519406 EPMC:9519406

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR004832

This entry represents MTCP1 and TCL1A/B from animals. They are encoded from a family of protooncogenes and function as Akt kinase coactivators [ PUBMED:10983986 ]. TCL1 also acts as an NFkappaB activator, through the interaction with p300, and as an inhibitor of AP1-dependent transcription [ PUBMED:19064921 ]. It affects both hair growth and epidermis integrity and is essential for mouse epidermal keratinocytes proliferation [ PUBMED:30286151 ].

Gene Ontology

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Domain organisation

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Seed source: [1] & Pfam-B_7391 (Release 8.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A
Number in seed: 17
Number in full: 326
Average length of the domain: 102.60 aa
Average identity of full alignment: 43 %
Average coverage of the sequence by the domain: 91.26 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.0 25.0
Trusted cut-off 25.8 32.3
Noise cut-off 24.7 20.8
Model length: 116
Family (HMM) version: 19
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Species distribution

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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the TCL1_MTCP1 domain has been found. There are 6 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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