Summary: TCL1/MTCP1 family
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This is the Wikipedia entry entitled "TCL1 MTCP1 protein domain". More...
TCL1 MTCP1 protein domain Edit Wikipedia article
TCL1_MTCP1 | |||||||||
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![]() crystal structure of p14tcl1, an oncogene product involved in t-cell prolymphocytic leukemia, reveals a novel b-barrel topology
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Identifiers | |||||||||
Symbol | TCL1_MTCP1 | ||||||||
Pfam | PF01840 | ||||||||
InterPro | IPR004832 | ||||||||
SCOP | 1jsg | ||||||||
SUPERFAMILY | 1jsg | ||||||||
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In molecular biology, TCL-1/MTCP-1 is a protein domain found in proteins encoded for by two related protooncogenes, other words by genes that help promote cancer. They are, T-cell leukemia/lymphoma protein 1A TCL1A encoded by oncogene TCL-1 SWISSPROT and Protein p13 MTCP-1 encoded by MTCP-1 SWISSPROT.
These are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28.[1]
Function
Enhances the phosphorylation and activation of Akt. Once Akt is activated this will in turn trigger cell survival. Further more it helps to stabilise mitochondrial membrane potential.[2][3]
Structure
This protein exists as a homodimer. It interacts with AKT1, AKT2 and AKT3 via the PH protein domain. It interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.
References
- ^ Fu ZQ, Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Rothstein JL, Croce CM, Weber IT, Harrison RW (March 1998). "Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3413–8. doi:10.1073/pnas.95.7.3413. PMC 19850
. PMID 9520380.
- ^ Pekarsky Y, Koval A, Hallas C, Bichi R, Tresini M, Malstrom S, et al. (2000). "Tcl1 enhances Akt kinase activity and mediates its nuclear translocation". Proc Natl Acad Sci U S A. 97 (7): 3028–33. doi:10.1073/pnas.040557697. PMC 16186
. PMID 10716693.
- ^ Laine J, Künstle G, Obata T, Sha M, Noguchi M (2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol Cell. 6 (2): 395–407. doi:10.1016/S1097-2765(00)00039-3. PMID 10983986.
This article incorporates text from the public domain Pfam and InterPro IPR004832
This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.
This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.
TCL1/MTCP1 family Provide feedback
Two related oncogenes, TCL-1 P56279 and MTCP-1 P56278 are overexpressed in T cell prolymphocytic leukaemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28 [1]. This family contains two repeated motifs that form a single globular domain [1].
Literature references
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Fu ZQ, Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Rothstein JL, Croce CM, Weber IT, Harrison RW; , Proc Natl Acad Sci U S A 1998;95:3413-3418.: Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies. PUBMED:9520380 EPMC:9520380
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Hoh F, Yang YS, Guignard L, Padilla A, Stern MH, Lhoste JM, van Tilbeurgh H; , Structure 1998;6:147-155.: Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology. PUBMED:9519406 EPMC:9519406
External database links
HOMSTRAD: | tcl1_mtcp1 |
SCOP: | 1jsg |
This tab holds annotation information from the InterPro database.
InterPro entry IPR004832
This entry represents MTCP1 and TCL1A/B from animals. They are encoded from a family of protooncogenes and function as Akt kinase coactivators [PUBMED:10983986]. TCL1 also acts as an NFkappaB activator, through the interaction with p300, and as an inhibitor of AP1-dependent transcription [PUBMED:19064921]. It affects both hair growth and epidermis integrity and is essential for mouse epidermal keratinocytes proliferation [PUBMED:30286151].
Gene Ontology
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
Molecular function | protein serine/threonine kinase activator activity (GO:0043539) |
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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Alignments
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...
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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (17) |
Full (215) |
Representative proteomes | UniProt (356) |
NCBI (487) |
Meta (0) |
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RP15 (13) |
RP35 (33) |
RP55 (88) |
RP75 (180) |
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key:
available,
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Seed (17) |
Full (215) |
Representative proteomes | UniProt (356) |
NCBI (487) |
Meta (0) |
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RP15 (13) |
RP35 (33) |
RP55 (88) |
RP75 (180) |
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Raw Stockholm | |||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
Trees
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Curation
Seed source: | [1] & Pfam-B_7391 (Release 8.0) |
Previous IDs: | none |
Type: | Family |
Sequence Ontology: | SO:0100021 |
Author: |
Bateman A |
Number in seed: | 17 |
Number in full: | 215 |
Average length of the domain: | 104.30 aa |
Average identity of full alignment: | 44 % |
Average coverage of the sequence by the domain: | 93.68 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 115 | ||||||||||||
Family (HMM) version: | 18 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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Interactions
There is 1 interaction for this family. More...
TCL1_MTCP1Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the TCL1_MTCP1 domain has been found. There are 6 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.
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