Summary: SCP-2 sterol transfer family
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This is the Wikipedia entry entitled "Sterol carrier protein". More...
Sterol carrier protein Edit Wikipedia article
![]() Sterol carrier protein 2 | |||||||||
Identifiers | |||||||||
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Symbol | SCP2 | ||||||||
Pfam | PF02036 | ||||||||
InterPro | IPR003033 | ||||||||
PROSITE | PDOC00092 | ||||||||
SCOPe | 1qnd / SUPFAM | ||||||||
OPM superfamily | 135 | ||||||||
OPM protein | 2cx7 | ||||||||
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Sterol carrier proteins (also known as nonspecific lipid transfer proteins) is a family of proteins that transfer steroids and probably also phospholipids and gangliosides between cellular membranes.
These proteins are different from plant nonspecific lipid transfer proteins but structurally similar to small proteins of unknown function from Thermus thermophilus.
This domain is involved in binding sterols. The human sterol carrier protein 2 (SCP2) is a basic protein that is believed to participate in the intracellular transport of cholesterol and various other lipids.[1]
Human proteins containing this domain
See also
References
- ^ Johansson J, Wuthrich K, Szyperski T, Scheek S, Assmann G, Seedorf U (1993). "NMR determination of the secondary structure and the three-dimensional polypeptide backbone fold of the human sterol carrier protein 2". FEBS Lett. 335 (1): 18–26. doi:10.1016/0014-5793(93)80431-S. PMID 8243660.
External links
- Sterol carrier proteins in SCOP
- SCP-2 sterol transfer family in Pfam
- UMich Orientation of Proteins in Membranes families/superfamily-144
- sterol+carrier+proteins at the US National Library of Medicine Medical Subject Headings (MeSH)
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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.
SCP-2 sterol transfer family Provide feedback
This domain is involved in binding sterols. It is found in the SCP2 protein P22307 as well as the C terminus of P51659 the enzyme estradiol 17 beta-dehydrogenase EC:1.1.1.62. The UNC-24 protein Q17372 contains an SPFH domain PF01145 [2].
Literature references
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Szyperski T, Scheek S, Johansson J, Assmann G, Seedorf U, Wuthrich K; , FEBS Lett 1993;335:18-26.: NMR determination of the secondary structure and the three-dimensional polypeptide backbone fold of the human sterol carrier protein 2. PUBMED:8243660 EPMC:8243660
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Barnes TM, Jin Y, Horvitz HR, Ruvkun G, Hekimi S; , J Neurochem 1996;67:46-57.: The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein. PUBMED:8667025 EPMC:8667025
Internal database links
SCOOP: | Alkyl_sulf_C MDMPI_C SCP2_2 |
Similarity to PfamA using HHSearch: | Alkyl_sulf_C |
External database links
SCOP: | 1qnd |
This tab holds annotation information from the InterPro database.
InterPro entry IPR003033
This domain is involved in binding sterols, and is found in proteins such as SCP2. This domain has a 3-layer alpha/beta/alpha fold, composed of alpha/beta(3)/(crossover)/beta/(alpha)/beta.
The human sterol carrier protein 2 (SCP2), also known as nonspecific lipid transfer protein, is a basic protein that is believed to participate in the intracellular transport of cholesterol and various other lipids [PUBMED:8243660]. The Unc-24 protein of Caenorhabditis elegans contains a domain similar to part of two ion channel regulators (the erythrocyte integral membrane protein stomatin and the C. elegans neuronal protein MEC-2) juxtaposed to a domain similar to nonspecific lipid transfer protein (nsLTP; also called sterol carrier protein 2) [PUBMED:8667025].
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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Pfam Clan
Alignments
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...
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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (113) |
Full (7442) |
Representative proteomes | UniProt (27195) |
NCBI (36763) |
Meta (663) |
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RP15 (1018) |
RP35 (2800) |
RP55 (5868) |
RP75 (10422) |
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Jalview | |||||||||
HTML | |||||||||
PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
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Seed (113) |
Full (7442) |
Representative proteomes | UniProt (27195) |
NCBI (36763) |
Meta (663) |
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RP15 (1018) |
RP35 (2800) |
RP55 (5868) |
RP75 (10422) |
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Raw Stockholm | |||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
Trees
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Curation
Seed source: | Pfam-B_1050 (Release 5.1) |
Previous IDs: | none |
Type: | Family |
Sequence Ontology: | SO:0100021 |
Author: |
Bateman A |
Number in seed: | 113 |
Number in full: | 7442 |
Average length of the domain: | 99.50 aa |
Average identity of full alignment: | 19 % |
Average coverage of the sequence by the domain: | 41.46 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 101 | ||||||||||||
Family (HMM) version: | 18 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SCP2 domain has been found. There are 32 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.
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