Summary: Olfactomedin-like domain
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Olfactomedin-like domain Provide feedback
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External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR003112
The olfactomedin-domain was first identified in olfactomedin, an extracellular matrix protein of the olfactory neuroepithelium [PUBMED:12615070]. Members of this extracellular domain-family have since been shown to be present in several metazoan proteins, such as latrophilins, myocilins, optimedins and noelins, the latter being involved in the generation of neural crest cells. Myocilin is of considerable interest, as mutations in its olfactomedin-domain can lead to glaucoma [PUBMED:14764620]. The olfactomedin-domains in myocilin and optimedin are essential for the interaction between these two proteins [PUBMED:12019210].
|Molecular function||protein binding (GO:0005515)|
- the number of sequences which exhibit this architecture
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This example describes an architecture with one
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Alignment kindly provided by SMART|
|Number in seed:||40|
|Number in full:||1087|
|Average length of the domain:||245.70 aa|
|Average identity of full alignment:||37 %|
|Average coverage of the sequence by the domain:||33.48 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||11|
|Download:||download the raw HMM for this family|
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