Summary: Repeat in HS1/Cortactin
Repeat in HS1/Cortactin Provide feedback
Wu H, Reynolds AB, Kanner SB, Vines RR, Parsons JT; , Mol Cell Biol 1991;11:5113-5124.: Identification and characterization of a novel cytoskeleton-associated pp60src substrate. PUBMED:1922035 EPMC:1922035
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This tab holds annotation information from the InterPro database.
InterPro entry IPR003134
The cortactin or HS1 repeat is a tandem repeat of 37-amino acid actin-binding domains. The repeat is named after human cortactin and HS1, proteins involved in cytoskeletal rearrangements implicated in cell migration and apoptosis, respectively. Cortactin contains 6.5 tandem copies of the repeat and is conserved among metazoans, although e.g. insect cortactin and splice variants contain fewer copies. Hematopoietic lineage cell specific protein 1 (HS1) contains 3.5 tandem copies of the cortactin repeat and is mainly expressed in hematopoietic cells. Both cortactin and HS1 contain a C-terminal SH3 domain (INTERPRO). The cortactin repeat domain binds filamentous actin (F-actin) in proteins that modulate the assembly of the actin cytoskeleton. Secondary structure predictions indicate that the cortactin repeat could exhibit a helix-turn-helix structure [PUBMED:12534372, PUBMED:15186216].
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Curation and family details
|Seed source:||Pfam-B_5631 (Release 5.2)|
|Number in seed:||103|
|Number in full:||1438|
|Average length of the domain:||34.50 aa|
|Average identity of full alignment:||58 %|
|Average coverage of the sequence by the domain:||33.20 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||11|
|Download:||download the raw HMM for this family|
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