Summary: Adenovirus E3 region protein CR1
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Adenovirus E3 region protein CR1 Provide feedback
Early region 3 (E3) of human adenoviruses (Ads) codes for proteins that appear to control viral interactions with the host . This region called CR1 (conserved region 1)  is found three times in Adenovirus type 19 (a subgroup D virus) 49 Kd protein in the E3 region. CR1 is also found in the 20.1 Kd protein of subgroup B adenoviruses. The function of this 80 amino acid region is unknown. This region is probably a divergent immunoglobulin domain (A. Bateman pers. observation).
Deryckere F, Burgert HG; , J Virol 1996;70:2832-2841.: Early region 3 of adenovirus type 19 (subgroup D) encodes an HLA-binding protein distinct from that of subgroups B and C. PUBMED:8627757 EPMC:8627757
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This tab holds annotation information from the InterPro database.
InterPro entry IPR003471Early region 3 (E3) of human adenoviruses (Ads) codes for proteins that appear to control viral interactions with the host [PUBMED:8627757]. This region called CR1 (conserved region 1) [PUBMED:8627757] is found three times in Human adenovirus 19 (a subgroup D virus) 49 Kd protein in the E3 region. CR1 is also found in the 20.1 Kd protein of subgroup B adenoviruses. The function of this 80 amino acid region is unknown. This region is probably a divergent immunoglobulin domain.
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Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. The superfamily can be divided into discrete structural sets, by the presence or absence of beta-strands in the structure and the length of the domains . Proteins containing domains of the C1 and V-sets are mostly molecules of the vertebrate immune system. Proteins of the C2-set are mainly lymphocyte antigens, this differs from the composition of the C2-set as originally proposed . The I-set is intermediate in structure between the C1 and V-sets and is found widely in cell surface proteins as well as intracellular muscle proteins.
The clan contains the following 24 members:A2M Adeno_E3_CR1 Adhes-Ig_like C1-set C2-set C2-set_2 Herpes_gE Herpes_gI Herpes_glycop_D I-set ICAM_N ig Ig_2 Ig_3 Ig_Tie2_1 IZUMO K1 Lep_receptor_Ig Marek_A PTCRA Receptor_2B4 SVA V-set V-set_CD47
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Curation and family details
|Seed source:||Pfam-B_1854 (release 5.4)|
|Number in seed:||20|
|Number in full:||217|
|Average length of the domain:||58.70 aa|
|Average identity of full alignment:||42 %|
|Average coverage of the sequence by the domain:||36.33 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||10|
|Download:||download the raw HMM for this family|
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