Summary: Type II secretion system (T2SS), protein I
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Type II secretion system (T2SS), protein I Provide feedback
The Type II secretion system, also called Secretion-dependent pathway (SDP), is responsible for the transport of proteins across the outer membrane first exported to the periplasm by the Sec or Tat translocon in Gram-negative (diderm) bacteria. As members of the T2SJ family, members of the T2SI family are pseudopilins containing prepilin signal sequences .
Howard SP, Critch J, Bedi A; , J Bacteriol 1993;175:6695-6703.: Isolation and analysis of eight exe genes and their involvement in extracellular protein secretion and outer membrane assembly in Aeromonas hydrophila. PUBMED:8407845 EPMC:8407845
Peabody CR, Chung YJ, Yen MR, Vidal-Ingigliardi D, Pugsley AP, Saier MH Jr;, Microbiology. 2003;149:3051-3072.: Type II protein secretion and its relationship to bacterial type IV pili and archaeal flagella. PUBMED:14600218 EPMC:14600218
Desvaux M, Hebraud M, Talon R, Henderson IR;, Trends Microbiol. 2009;17:139-145.: Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue. PUBMED:19299134 EPMC:19299134
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR003413
The bacterial general secretion pathway (GSP) is involved in the export of proteins. Five secretion pathways that permit the secretion of soluble proteins have been described [PUBMED:15223057]. This group consists of type II secretion system protein I (sometimes known as general secretion pathway protein I). The Type II secretion system is responsible for the transport of proteins across the outer membrane first exported to the periplasm by the Sec or Tat translocon in Gram-negative bacteria. Like members of the T2SJ family, members of the T2SI family are pseudopilins containing prepilin signal sequences [PUBMED:8407845].
This entry represents a domain that does not include the T2SI prepilin signal sequence.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||type II protein secretion system complex (GO:0015627)|
|Molecular function||protein transporter activity (GO:0008565)|
|Biological process||protein secretion by the type II secretion system (GO:0015628)|
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This is a clan contains bacterial pilus subunits and proteins involved in secretion. Pili proteins enable the transfer of plasmid between bacteria. The families in this clan adopt an alpha helical structure which is packed against a beta sheet [2-3].
The clan contains the following 10 members:Bundlin N_methyl N_methyl_2 N_methyl_3 Pilin PilS T2SG T2SI TcpA YadA_anchor
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Curation and family details
|Seed source:||Pfam-B_2607 (release 5.4)|
|Author:||Mian N, Bateman A, Desvaux M|
|Number in seed:||100|
|Number in full:||934|
|Average length of the domain:||81.20 aa|
|Average identity of full alignment:||28 %|
|Average coverage of the sequence by the domain:||65.20 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||12|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the T2SI domain has been found. There are 9 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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