Summary: Spin/Ssty Family
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Spindlin (Spin) is a novel maternal transcript present in the unfertilised egg and early embryo . The Y-linked spermiogenesis -specific transcript (Ssty) is also expressed during gametogenesis and forms part of this Pfam family. Members of this family contain three copies of this 50 residue repeat. The repeat is predicted to contain four beta strands.
Oh B, Hwang SY, Solter D, Knowles BB; , Development 1997;124:493-503.: Spindlin, a major maternal transcript expressed in the mouse during the transition from oocyte to embryo. PUBMED:9053325 EPMC:9053325
Staub E, Mennerich D, Rosenthal A; , Genome Biol 2002;3:0-0.: The Spin/Ssty repeat: a new motif identified in proteins involved in vertebrate development from gamete to embryo. PUBMED:11806826 EPMC:11806826
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR003671
Spindlin (Spin) and Ssty were first identified for their involvement in gametogenesis. Spindlin was identified as a maternal transcript present in the unfertilised egg and early embryo, and was subsequently shown to interact with the spindle apparatus during oogenesis, and may therefore be important for mitosis [PUBMED:9053325]. In addition, spindlin appears to be a target for cell cycle-dependent phosphorylation, and as such may play a role in cell cycle regulation during the transition from gamete to embryo [PUBMED:11806826]. Ssty is a multi-copy, Y-linked spermatogenesis-specific transcript that appears to be required for normal spermatogenesis [PUBMED:15020475]. Ssty may play an analogous role to spindlin in sperm cells, namely during the transition from sperm cells to early embryo, and in mitosis.
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|Biological process||gamete generation (GO:0007276)|
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Curation and family details
|Seed source:||Staub E|
|Author:||Staub E, Mian N, Bateman A|
|Number in seed:||27|
|Number in full:||646|
|Average length of the domain:||48.10 aa|
|Average identity of full alignment:||42 %|
|Average coverage of the sequence by the domain:||57.44 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||12|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Spin-Ssty domain has been found. There are 6 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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