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3  structures 5117  species 0  interactions 25097  sequences 259  architectures

Family: Zip (PF02535)

Summary: ZIP Zinc transporter

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This is the Wikipedia entry entitled "Zinc transporter protein". More...

Zinc transporter protein Edit Wikipedia article

Zinc transporter proteins, or simply zinc transporters, are membrane transport proteins of the solute carrier family which control the membrane transport of zinc and regulate its intracellular and cytoplasmic concentrations.[1] They include two major groups: (1) the zinc transporter (ZnT) or solute carrier 30 (SLC30) family, which controls the efflux of zinc from the cytoplasm out of the cell and from the cytoplasm into vesicles; and (2) the zinc importer, Zrt- and Irt-like protein (ZIP), or solute carrier 39A (SLC39A) family, which controls the influx of zinc into the cytoplasm from outside of the cell and from vesicles.[1]

One zinc transporter, ZIP9, is also a membrane androgen receptor.[2]


ZnT (SLC30)

ZnT1, ZnT2, ZnT3, ZnT4, ZnT5, ZnT6, ZnT7, ZnT8, ZnT9, ZnT10


ZIP1, ZIP2, ZIP3, ZIP4, ZIP5, ZIP6, ZIP7, ZIP8, ZIP9, ZIP10, ZIP11, ZIP12, ZIP13, ZIP14


  1. ^ a b Hara T, Takeda TA, Takagishi T, Fukue K, Kambe T, Fukada T (2017). "Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis". J Physiol Sci. 67 (2): 283–301. doi:10.1007/s12576-017-0521-4. PMID 28130681.
  2. ^ Thomas P, Converse A, Berg HA (2017). "ZIP9, a novel membrane androgen receptor and zinc transporter protein". Gen. Comp. Endocrinol. doi:10.1016/j.ygcen.2017.04.016. PMID 28479083.

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

ZIP Zinc transporter Provide feedback

The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant [1]. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.

Literature references

  1. Grotz N, Fox T, Connolly E, Park W, Guerinot ML, Eide D; , Proc Natl Acad Sci U S A 1998;95:7220-7224.: Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency. PUBMED:9618566 EPMC:9618566

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR003689

These ZIP zinc transporter proteins define a family of metal ion transporters that are found in plants, protozoa, fungi, invertebrates, and vertebrates, making it now possible to address questions of metal ion accumulation and homeostasis in diverse organisms [ PUBMED:9618566 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan DMT (CL0184), which has the following description:

This clan contains a variety of transporters which have 4, 5, 9 or 10 membrane spanning helices. Many of the 10 membrane spanning transporters appear to be a duplication of the 5 spanning unit [1]. Many of these families contain a characteristic glycine rich motif close to the C-terminus.

The clan contains the following 22 members:

CRCB CRT-like CSG2 DMT_6 DMT_YdcZ DUF5989 EamA EmrE Mg_trans_NIPA Multi_Drug_Res Nuc_sug_transp PUNUT RhaT SLC35F Sugar_transport TMEM144 TMEM234 TPT UAA UPF0060 Ureide_permease Zip


We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

Representative proteomes UniProt
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

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Representative proteomes UniProt

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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...


This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_1189 (release 5.4) & Pfam-B_1903 (Release 7.5)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bashton M , Bateman A
Number in seed: 37
Number in full: 25097
Average length of the domain: 239.5 aa
Average identity of full alignment: 17 %
Average coverage of the sequence by the domain: 70.67 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 35.1 35.1
Trusted cut-off 35.1 35.1
Noise cut-off 35.0 35.0
Model length: 333
Family (HMM) version: 25
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence


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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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The tree shows the occurrence of this domain across different species. More...


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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Zip domain has been found. There are 3 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A044QK04 View 3D Structure Click here
A0A044QUI0 View 3D Structure Click here
A0A044RGZ5 View 3D Structure Click here
A0A044RH04 View 3D Structure Click here
A0A044RHT1 View 3D Structure Click here
A0A044SSQ0 View 3D Structure Click here
A0A044TGY9 View 3D Structure Click here
A0A044TXT9 View 3D Structure Click here
A0A044U8D8 View 3D Structure Click here
A0A044UNR2 View 3D Structure Click here
A0A044VIX7 View 3D Structure Click here
A0A077YUQ3 View 3D Structure Click here
A0A077YY40 View 3D Structure Click here
A0A077YY65 View 3D Structure Click here
A0A077Z2T5 View 3D Structure Click here
A0A077Z892 View 3D Structure Click here
A0A077ZAH5 View 3D Structure Click here
A0A077ZDF8 View 3D Structure Click here
A0A077ZKN2 View 3D Structure Click here
A0A0D2ETL3 View 3D Structure Click here
A0A0D2EW27 View 3D Structure Click here
A0A0D2F3J9 View 3D Structure Click here
A0A0D2G075 View 3D Structure Click here
A0A0D2GD96 View 3D Structure Click here
A0A0D2H3V7 View 3D Structure Click here
A0A0D2H637 View 3D Structure Click here
A0A0D2HFS5 View 3D Structure Click here
A0A0G2KQY6 View 3D Structure Click here
A0A0H3GVR3 View 3D Structure Click here
A0A0H5S1E1 View 3D Structure Click here
A0A0H5S815 View 3D Structure Click here
A0A0I9N4G0 View 3D Structure Click here
A0A0J9XX63 View 3D Structure Click here
A0A0J9XYZ9 View 3D Structure Click here
A0A0K0DSZ3 View 3D Structure Click here
A0A0K0DUJ8 View 3D Structure Click here
A0A0K0DW96 View 3D Structure Click here
A0A0K0DXY8 View 3D Structure Click here
A0A0K0DZ36 View 3D Structure Click here
A0A0K0E927 View 3D Structure Click here