Summary: Metal-sensitive transcriptional repressor
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Metal-sensitive transcriptional repressor Provide feedback
This is a family of metal-sensitive repressors, involved in resistance to metal ions. Members of this family bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound to metal ions they are unable to bind DNA, leading to transcriptional derepression [1-5].
Liu T, Ramesh A, Ma Z, Ward SK, Zhang L, George GN, Talaat AM, Sacchettini JC, Giedroc DP;, Nat Chem Biol. 2007;3:60-68.: CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator. PUBMED:17143269 EPMC:17143269
Sakamoto K, Agari Y, Agari K, Kuramitsu S, Shinkai A;, Microbiology. 2010;156:1993-2005.: Structural and functional characterization of the transcriptional repressor CsoR from Thermus thermophilus HB8. PUBMED:20395270 EPMC:20395270
Marrero J, Auling G, Coto O, Nies DH;, Microb Ecol. 2007;53:123-133.: High-level resistance to cobalt and nickel but probably no transenvelope efflux: Metal resistance in the Cuban Serratia marcescens strain C-1. PUBMED:17186148 EPMC:17186148
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR003735
This is a family of metal-sensitive repressors, involved in resistance to metal ions. Members of this family bind copper, nickel or cobalt ions via conserved cysteine and histidine residues. In the absence of metal ions, these proteins bind to promoter regions and repress transcription. When bound to metal ions they are unable to bind DNA, leading to transcriptional derepression [PUBMED:17143269, PUBMED:20395270, PUBMED:17186148, PUBMED:17293508, PUBMED:16956381].
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Curation and family details
|Author:||Mian N, Bateman A, Eberhardt R|
|Number in seed:||147|
|Number in full:||4323|
|Average length of the domain:||83.60 aa|
|Average identity of full alignment:||30 %|
|Average coverage of the sequence by the domain:||88.61 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||12|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Trns_repr_metal domain has been found. There are 7 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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