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6  structures 18104  species 1  interaction 18296  sequences 3  architectures

Family: Exonuc_VII_S (PF02609)

Summary: Exonuclease VII small subunit

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This is the Wikipedia entry entitled "Exonuclease VII". More...

Exonuclease VII Edit Wikipedia article

Exonuclease VII, large subunit
Symbol Exonuc_VII_L
Pfam PF02601
InterPro IPR020579
Exonuclease VII small subunit
PDB 1vp7 EBI.jpg
crystal structure of exodeoxyribonuclease vii small subunit (np_881400.1) from bordetella pertussis at 2.40 a resolution
Symbol Exonuc_VII_S
Pfam PF02609
InterPro IPR003761

In molecular biology, exonuclease VII (EC, Escherichia coli exonuclease VII, E. coli exonuclease VII, endodeoxyribonuclease VII, Exodeoxyribonuclease VII) is a bacterial exonuclease enzyme.[1][2] It is composed of two nonidentical subunits; one large subunit and 4 small ones.[3] Exonuclease VII catalyses exonucleolytic cleavage in either 5'-3' or 3'-5' direction to yield 5'-phosphomononucleotides. The large subunit also contains an N-terminal OB-fold domain that binds to nucleic acids.


  1. ^ Chase, J.W. and Richardson, C.C. (1974). "Ribonuclease VII of Escherichia coli". J. Biol. Chem. 249 (14): 4545–4552. PMID 4602029. 
  2. ^ Chase, J.W. and Richardson, C.C. (1974). "Exonuclease VII of Escherichia coli". J. Biol. Chem. 249 (14): 4553–4561. PMID 4602030. 
  3. ^ Vales LD, Rabin BA, Chase JW (August 1982). "Subunit structure of Escherichia coli exonuclease VII". J. Biol. Chem. 257 (15): 8799–805. PMID 6284744. 

This article incorporates text from the public domain Pfam and InterPro IPR020579

This article incorporates text from the public domain Pfam and InterPro IPR003761

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Exonuclease VII small subunit Provide feedback

This family consist of exonuclease VII, small subunit EC: This enzyme catalyses exonucleolytic cleavage in either 5'->3' or 3'->5' direction to yield 5'-phosphomononucleotides. This exonuclease VII enzyme is composed of one large subunit and 4 small ones [1].

Literature references

  1. Vales LD, Rabin BA, Chase JW; , J Biol Chem 1982;257:8799-8805.: Subunit structure of Escherichia coli exonuclease VII. PUBMED:6284744 EPMC:6284744

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR003761

Exonuclease VII is composed of two non-identical subunits; one large subunit and 4 small ones [PUBMED:6284744]. This enzyme catalyses exonucleolytic cleavage in either 5'-3' or 3'-5' direction to yield nucleoside 5'-phosphates.

Gene Ontology

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Domain organisation

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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

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Seed source: COG1722
Previous IDs: none
Type: Family
Author: Bashton M, Bateman A
Number in seed: 891
Number in full: 18296
Average length of the domain: 52.00 aa
Average identity of full alignment: 40 %
Average coverage of the sequence by the domain: 66.16 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.8 20.8
Trusted cut-off 20.8 20.9
Noise cut-off 20.7 20.6
Model length: 52
Family (HMM) version: 12
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There is 1 interaction for this family. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Exonuc_VII_S domain has been found. There are 6 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.

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