Summary: Putative manganese efflux pump
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This is the Wikipedia entry entitled "Manganese exporter". More...
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Manganese exporter Edit Wikipedia article
|Putative Manganese Efflux Pump|
The Manganese (Mn2+) Exporter (MntP) Family (TC# 2.A.107) is a member of the Lysine Exporter (LysE) Superfamily. The MntP family is a small family whose members have been found in bacteria and archaea. MntP proteins are of about 200 amino acyl residues with 6 putative transmembrane segments (TMSs). The Conserved Domain Database (CDD) recognized two DUF204 repeats, each repeat having 3 TMSs. A representative list of proteins belonging to the MntP family can be found in the Transporter Classification Database.
At least one member (YebN of E. coli, TC# 2.A.107.1.1) has been shown to function as a putative manganese efflux pump. Manganese sensitivity and intracellular manganese levels significantly increased in bacteria when the mntP (formerly yebN) gene, which encodes the MntP efflux pump, was deleted. While manganese is a highly important trace nutrient for organisms from bacteria to humans, acting as an important element in the defense against oxidative stress and as an enzyme cofactor, it becomes toxic when present in excess.
- Tsu BV, Saier MH (2015-01-01). "The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis". PLOS ONE. 10 (10): e0137184. Bibcode:2015PLoSO..1037184T. doi:10.1371/journal.pone.0137184. PMCÂ 4608589. PMIDÂ 26474485.
- Waters LS, Sandoval M, Storz G (November 2011). "The Escherichia coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis". Journal of Bacteriology. 193 (21): 5887â€“97. doi:10.1128/JB.05872-11. PMCÂ 3194919. PMIDÂ 21908668.
- Martin JE, Waters LS, Storz G, Imlay JA (March 2015). "The Escherichia coli small protein MntS and exporter MntP optimize the intracellular concentration of manganese". PLOS Genetics. 11 (3): e1004977. doi:10.1371/journal.pgen.1004977. PMCÂ 4361602. PMIDÂ 25774656.
- Farcasanu IC, Hirata D, Tsuchiya E, Nishiyama F, Miyakawa T (September 1995). "Protein phosphatase 2B of Saccharomyces cerevisiae is required for tolerance to manganese, in blocking the entry of ions into the cells". European Journal of Biochemistry. 232 (3): 712â€“7. doi:10.1111/j.1432-1033.1995.712zz.x. PMIDÂ 7588708.
- Jensen AN, Jensen LT (2014). "Chapter 1: Manganese Transport, Trafficking and Function in Invertebrates". In Costa L, Aschner M (eds.). Manganese in Health and Disease. Issues in Toxicology. Royal Society of Chemistry. pp.Â 1â€“33. doi:10.1039/9781782622383-00001. ISBNÂ 978-1-84973-943-6.
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Putative manganese efflux pump Provide feedback
MntP is a family of bacterial proteins with a signal peptide and four transmembrane domains. It is a putative manganese efflux pump, since deletion of the gene leads to profound manganese sensitivity and elevated intracellular manganese levels in bacteria. Manganese is a highly important trace nutrient for organisms from bacteria to humans, and acts as an important element in the defence against oxidative stress and as an enzyme cofactor .
Waters LS, Sandoval M, Storz G;, J Bacteriol. 2011;193:5887-5897.: The Escherichia coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis. PUBMED:21908668 EPMC:21908668
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External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR003810
MntP is a family of bacterial proteins with a signal peptide and four transmembrane domains. It is a putative manganese efflux pump, since deletion of the gene leads to profound manganese sensitivity and elevated intracellular manganese levels in bacteria. Manganese is a highly important trace nutrient for organisms from bacteria to humans, and acts as an important element in the defence against oxidative stress and as an enzyme cofactor [ PUBMED:21908668 ].
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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This clan includes a diverse range of transporter families .
The clan contains the following 19 members:BacA Cad Colicin_V DsbD DsbD_2 DUF475 DUF6044 FTR1 HupE_UreJ HupE_UreJ_2 LysE MarC Mntp NicO OFeT_1 SfLAP TauE TerC UPF0016
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key: available, not generated, — not available.
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|Author:||Bashton M , Bateman A|
|Number in seed:||57|
|Number in full:||3906|
|Average length of the domain:||134.60 aa|
|Average identity of full alignment:||25 %|
|Average coverage of the sequence by the domain:||81.37 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||18|
|Download:||download the raw HMM for this family|
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The tree shows the occurrence of this domain across different species. More...
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For all of the domain matches in a full alignment, we count the number that are found on all sequences in the alignment. This total is shown in the purple box.
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AlphaFold Structure Predictions
The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.
The structural model below was generated by the Baker group with the trRosetta software using the Pfam UniProt multiple sequence alignment.
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