Summary: Galactose-1-phosphate uridyl transferase, C-terminal domain
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This is the Wikipedia entry entitled "Galactose-1-phosphate uridylyltransferase". More...
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Galactose-1-phosphate uridyl transferase, C-terminal domain Provide feedback
SCOP reports fold duplication with N-terminal domain. Both involved in Zn and Fe binding.
Literature references
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Wedekind JE, Frey PA, Rayment I; , Biochemistry 1995;34:11049-11061.: Three-dimensional structure of galactose-1-phosphate uridylyltransferase from Escherichia coli at 1.8 A resolution. PUBMED:7669762 EPMC:7669762
Internal database links
SCOOP: | DcpS_C DUF4921 DUF4931 HIT |
Similarity to PfamA using HHSearch: | DcpS_C |
External database links
PROSITE: | PDOC00108 |
SCOP: | 1hxp |
This tab holds annotation information from the InterPro database.
InterPro entry IPR005850
Galactose-1-phosphate uridyl transferase catalyses the conversion of UDP-glucose and alpha-D-galactose 1-phosphate to alpha-D-glucose 1-phosphate and UDP-galactose during galactose metabolism. The enzyme is present in prokaryotes and eukaryotes. Defects in GalT in humans is the cause of galactosemia, an inherited disorder of galactose metabolism that leads to jaundice, cataracts and mental retardation.
This domain describes the C-terminal of Galactose-1-phosphate uridyl transferase. SCOP reports fold duplication of the C-terminal with the N-terminal domain. Both are involved in Zn and Fe binding
Gene Ontology
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
Molecular function | UDP-glucose:hexose-1-phosphate uridylyltransferase activity (GO:0008108) |
Biological process | galactose metabolic process (GO:0006012) |
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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Pfam Clan
This family is a member of clan HIT (CL0265), which has the following description:
The HIT superfamily are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides [1].
The clan contains the following 8 members:
CDH CwfJ_C_1 DcpS_C DUF4921 DUF4931 GalP_UDP_tr_C GalP_UDP_transf HITAlignments
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...
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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (8) |
Full (3843) |
Representative proteomes | UniProt (15868) |
NCBI (24804) |
Meta (238) |
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RP15 (468) |
RP35 (1710) |
RP55 (3540) |
RP75 (6227) |
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key:
available,
not generated,
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
Seed (8) |
Full (3843) |
Representative proteomes | UniProt (15868) |
NCBI (24804) |
Meta (238) |
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---|---|---|---|---|---|---|---|---|---|
RP15 (468) |
RP35 (1710) |
RP55 (3540) |
RP75 (6227) |
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Raw Stockholm | |||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
Trees
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Curation
Seed source: | Prosite |
Previous IDs: | GalP_UDP_trans_C; |
Type: | Domain |
Sequence Ontology: | SO:0000417 |
Author: |
Finn RD |
Number in seed: | 8 |
Number in full: | 3843 |
Average length of the domain: | 171.10 aa |
Average identity of full alignment: | 29 % |
Average coverage of the sequence by the domain: | 43.01 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 167 | ||||||||||||
Family (HMM) version: | 18 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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Interactions
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the GalP_UDP_tr_C domain has been found. There are 15 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.
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