# STOCKHOLM 1.0 #=GF ID THUMP #=GF AC PF02926.18 #=GF DE THUMP domain #=GF AU Aravind L;0000-0003-0771-253X #=GF SE Aravind L #=GF GA 20.60 20.60; #=GF TC 20.60 20.60; #=GF NC 20.50 20.50; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq #=GF TP Domain #=GF RN [1] #=GF RM 11295541 #=GF RT THUMP - a predicted RNA-binding domain shared by 4-thiouridine, #=GF RT pseudouridine synthases and RNA methylases. #=GF RA Aravind L, Koonin EV; #=GF RL Trends Biochem Sci 2001;26:215-217. #=GF RN [2] #=GF RM 16343540 #=GF RT Crystal structure of Bacillus anthracis ThiI, a tRNA-modifying #=GF RT enzyme containing the predicted RNA-binding THUMP domain. #=GF RA Waterman DG, Ortiz-Lombardia M, Fogg MJ, Koonin EV, Antson AA; #=GF RL J Mol Biol. 2006;356:97-110. #=GF DR INTERPRO; IPR004114; #=GF DR SCOP; 2c5s; fa; #=GF DR SO; 0000417; polypeptide_domain; #=GF CC The THUMP domain is named after after thiouridine synthases, #=GF CC methylases and PSUSs [1]. The THUMP domain consists of about 110 #=GF CC amino acid residues. The structure of ThiI reveals that the #=GF CC THUMP has a fold unlike that of previously characterised #=GF CC RNA-binding domains [2]. It is predicted that this domain is an #=GF CC RNA-binding domain The THUMP domain probably functions by #=GF CC delivering a variety of RNA modification enzymes to their #=GF CC targets [1]. #=GF SQ 48 #=GS O57838_PYRHO/14-147 AC O57838.1 #=GS Q9V2I4_PYRAB/14-147 AC Q9V2I4.1 #=GS TMG10_METTH/17-147 AC O26820.1 #=GS TMG10_METJA/16-165 AC Q58120.1 #=GS TMG10_ARCFU/17-136 AC O29011.1 #=GS O58076_PYRHO/17-142 AC O58076.1 #=GS TMG10_PYRAB/16-141 AC Q9UY84.2 #=GS YPSC_BACSU/20-156 AC P50840.1 #=GS Y064_SYNY3/28-164 AC Q55156.1 #=GS A1KVH2_NEIMF/21-157 AC A1KVH2.1 #=GS RLMKL_HAEIN/18-154 AC P44524.2 #=GS RLMKL_ECOLI/18-154 AC P75864.1 #=GS RLMKL_ECOLI/18-154 DR PDB; 3V8V B; 11-154; #=GS RLMKL_ECOLI/18-154 DR PDB; 3V97 A; 11-154; #=GS RLMKL_ECOLI/18-154 DR PDB; 3V8V A; 11-154; #=GS RLMKL_ECOLI/18-154 DR PDB; 3V97 B; 11-154; #=GS O58378_PYRHO/17-180 AC O58378.1 #=GS Q9UYW2_PYRAB/18-181 AC Q9UYW2.1 #=GS TRM14_METJA/17-157 AC Q57880.1 #=GS TRM14_ARCFU/47-183 AC O28105.1 #=GS Q9YEM1_AERPE/17-164 AC Q9YEM1.1 #=GS Y1257_METJA/19-160 AC Q58654.1 #=GS O26994_METTH/35-174 AC O26994.1 #=GS Q7LXJ8_SACS2/22-158 AC Q7LXJ8.1 #=GS THII_ECOLI/28-165 AC P77718.1 #=GS THII_MYCGE/32-165 AC P47612.1 #=GS THII_MYCPN/34-167 AC P75228.1 #=GS THII_METJA/35-176 AC Q58341.1 #=GS E7FHT9_PYRFU/25-153 AC E7FHT9.1 #=GS O59053_PYRHO/28-167 AC O59053.1 #=GS O59053_PYRHO/28-167 DR PDB; 1VBK B; 28-167; #=GS O59053_PYRHO/28-167 DR PDB; 1VBK A; 28-167; #=GS Q9V0F6_PYRAB/28-167 AC Q9V0F6.1 #=GS THII_TREPA/31-168 AC O83570.1 #=GS THII_ARCFU/29-153 AC O29382.1 #=GS THII_BACSU/29-165 AC O34595.2 #=GS THII_THEMA/30-162 AC Q9X220.1 #=GS THII_THEMA/30-162 DR PDB; 4KR9 A; 25-162; #=GS THII_THEMA/30-162 DR PDB; 4KR6 B; 25-162; #=GS THII_THEMA/30-162 DR PDB; 4KR7 B; 25-162; #=GS THII_THEMA/30-162 DR PDB; 4KR6 A; 25-162; #=GS THII_THEMA/30-162 DR PDB; 4KR9 B; 25-162; #=GS THII_THEMA/30-162 DR PDB; 4KR7 A; 25-162; #=GS THII_AERPE/30-166 AC Q9YEW8.2 #=GS THII_METTH/32-165 AC O27720.1 #=GS Q21503_CAEEL/58-198 AC Q21503.2 #=GS PUS10_AERPE/24-198 AC Q9YEN2.2 #=GS O73996_PYRHO/37-175 AC O73996.1 #=GS Q9V0E5_PYRAB/21-158 AC Q9V0E5.1 #=GS O27377_METTH/24-159 AC O27377.1 #=GS PUS10_ARCFU/5-118 AC O29113.1 #=GS Q9YCV6_AERPE/13-149 AC Q9YCV6.2 #=GS O28057_ARCFU/16-147 AC O28057.1 #=GS Y421_METJA/17-148 AC Q57864.1 #=GS Q9V2I9_PYRAB/17-149 AC Q9V2I9.1 #=GS Q9Y954_AERPE/23-165 AC Q9Y954.2 #=GS TAN1_YEAST/99-259 AC P53072.1 #=GS YB0A_SCHPO/90-239 AC P87151.2 #=GS O61900_CAEEL/101-251 AC O61900.2 #=GS O60362_HUMAN/4-143 AC O60362.1 O57838_PYRHO/14-147 EAILEL..EWGIEAKVRRTRWGGVLIGETELNKEEVFKRLQSFETF............ALQKIIPI............DLFIPLEKLNDVIGEIATKIPKGK.......SFAVRAKVRGA.................KIGEKSLEIEIGGLIKRITG.......NPVNLENPEYLLIIEVLGK.KAGVALIK Q9V2I4_PYRAB/14-147 DAILEL..EWGIGAKVKRTKWRGVLVGETELEKEEAIRKLKSFETF............ALQRFIPI............DSLIPLERLEEEIKRLCSKIPMGK.......SFAVRAKVRGA.................KIGEKKLETEIGGLIKRITG.......NPVNLGNPDIIVTIEVLGN.KAGIGILK TMG10_METTH/17-147 AELRSVLMSEGIDFSVIESGSGYEVIDAPRSTWKILKKRLAYAHEISE.............................VIGYAAADDLDDAAEEIDWSKYVRE.......SFAVRIRKLCG.................DVDSRTLERTIGAIIKEDTG.......LKVDLEKPWTLIRPVLIND.RFILTRRL TMG10_METJA/16-165 GELMALLEIFNYNGSVERLKRYVITEDSPAKDIVKRSGYIDEGHRIIFRYNLEEKSVDLVDKIVND................FINSFKDFVANIDYPDIDESK......SYAVRVLKLHKDEF............TKSIDSLRIEKEIGGIIKLKTN.......AKVNLTKPDILVRVVILEN.TFFISNVL TMG10_ARCFU/17-136 KEVLVLAERYGW.VEDYQFEERLLLLDYAGEKFFERLAYTNEVTKIYD.............................ICSVSELEQVFSEIPVYDR.............LCCVRVKG....................GKGKTALERKLGALLWKRGA........KVSVSNPEIVYKVYIQDD.KCYVGLLE O58076_PYRHO/17-142 AEVEALAELGVGNVEKVDY.....LLVSGSVKHIGVFERLGLAHEYGL............................LLYEGDDIKDILDFAKGLEWRNIING.......TFAVRRERMRNC................MHEVNDLDKKIGGIIHSQGL........RVNLSRPDTVVRVYCGN..KIWLGIRI TMG10_PYRAB/16-141 AEVKALAELRNGTIKERDY.....LLVVGNVENVEIFERLGLAHEYGI............................LLGSGDDVRDILDLVRGLEWKEIIKG.......TFAVRKEVMVNC................AHEVKNLEKIIGGIIHSQGL........RVNLSKPDTIIKVYCGR..KLWIGIRI YPSC_BACSU/20-156 KEVRDLGYECKVDNGKVIFEG..............DALAICRANLWLR..........TADRIKVQ.........VASFKAKTFDELFEKTKAINWRSFIPENG.....KFPVIGKSVKST................LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKD.QALITLDS Y064_SYNY3/28-164 QELTEL.............GAEQVKPEFAGVAFIGDRALLYRINLWSR..........LIYRVLMP.........MATVKAFNAQDLYRSIKKIDWDEYFSPEQ.....TLQINCTGKNPQLN............HSHFTALQVKNAIVDQQRDRYQR.....RSSVDLEQPDIVINAHIHQN.HCQLSLDS A1KVH2_NEIMF/21-157 QELESL.............GCTDVQVFDGGVSCRGGLEQVYAANLHSR..........TAGRILLR.........LTKGTYRTERDIYKLAKNINWFNWFTLQQ.....TFKVKIEAKRANVK............SLQFVGLTVKDAVCDAFRDIYDA.....RPSVDKAAPDVRIHAFLDER.NVEIFIDT RLMKL_HAEIN/18-154 VELTEL.............GAQEAKVVQGGVHYQADDETLYRTLLWSR..........LASRILFP.........LIETKIYSDLDLYAAVSGFNWLAQFDERV.....TFFVDFNGTNQEIR............HTQFGAMRVKDGIVDYFERQGKT.....RPDVDKIQPDVRIHAYLNRE.NLVISLDL RLMKL_ECOLI/18-154 TELENL.............GAVECQVVQGGVHFKGDTRLVYQSLMWSR..........LASRIMLP.........LGECKVYSDLDLYLGVQAINWTEMFNPGA.....TFAVHFSGLNDTIR............NSQYGAMKVKDAIVDAFTRKNLP.....RPNVDRDAPDIRVNVWLHKE.TASIALDL #=GR RLMKL_ECOLI/18-154 SS HHHHHT.............T-EEEEEETTEEEEEE-HHHHHHHHHH-S..........S-SEEEEE.........EEEEE-SSHHHHHHHHHTS-HHHHB-TT-.....-EEEEEE---SS--............SHHHHHHHHHHHHHHHHHTTT--.....---B-SSS-SEEEEEEEETT.EEEEEEES O58378_PYRHO/17-180 KEIMELLKENTVTIQEKPFNVEGRLLVEVKETFYTDEKGRKRPFEFATYLN...EKSKTLHRVIIEIASHEFKGITEENPEKALKRIEEFTVNIPVERFIKVTE.....SFAVRAFRKGEH................TITSVDIARVVGKAIFDRLSRI...GSPIVNLDHPSTIVRAELINE.AFFLGIDT Q9UYW2_PYRAB/18-181 REVLNLLGDSVVRIEEKPFNVEGRILVEVKEKEYKDEKGRKRPFDFATYLN...ENSRLLHRVIVEIASTKFEGIEREDPEKALKRIEDFVSEIPVEKFVKVSE.....SFAVRSFREGEH................EVTSVDIARIVGKAIFERLSRF...GTPRVNLDHPTVIFRAELIGE.AFFLGIDT TRM14_METJA/17-157 NEIESF....GGKIKEIRENKGRIFFSG.......DLKLIPKINYLSR..........TIERMNILL.......HREEIPNIALDDIYKRVYNIDWTEWIKENQ.....SFAIRPLRAGEH................NFTSIDIGRVAGEAVIKSYQRDK.NIRLKVNLDEPDVIVRVEVIFD.ELIVGIDT TRM14_ARCFU/47-183 KEVESF....GCKVEEIRERRGRIFFSG.......EKSAIPLLNHFSR..........TLERLNVL.........LLRCEVEGLDDIYAAVKGLDFSFVKGK.......SFAIRSLRVGEH................DFTSMDIARVAGQAVIDSFMESY.GERLKVNLNQPDVIIRVELVDS.ELFVGVDT Q9YEM1_AERPE/17-164 REIVEE..VDSAKVEEVGEYRGRIVFRSSGEPWLVAEQIYGLRSIHSA..........SLLLAEAE..........VSPGREGLEEVWRAAYKSGAHLHIPYGA.....TFAVRGERIGEGH...............SYTSVEIASTVGDAVQRAAEESL.GWRPMVRLNSPQVVLHAEVDIF.TFRLGVLL Y1257_METJA/19-160 EELNKLPIKKKILWTPFRG.....ILKVLSQNPYEFLNIIKENKNNLK..........FSLRIIPL..........EIGCQTDINEIKKAISFLINKKKEKLKN....KSFVVRCNRRGNH................EFTSEELERIIGEYVLENFKD....LNLRVNLKDWDFKINIEILQD.ESYISIFQ O26994_METTH/35-174 EETEMALSRYEGELRVIESDFPNVMMFDLNMDPLEAVNIIKNSPTT............VISKVVPV..........EAVVRTRLDSILEKVIALVSEKVEAGE......TFRVICDLRGRRY...............IRSAGELVEAVSEALMERFP........ITESDEPDWIIQIEVVGD.STGVSVLR Q7LXJ8_SACS2/22-158 NEILNRILIKDIDARVIEYVQNVAIVYSNLDSLVVYGLLFASPPSCAE.............KVYPF.........QLIINSTNEKEIVVNVINFIKNKTKDLK......TFYVRCYNRGI.................DVNCREIEMGVGIGLKGLIN.........VDFKDPEVVLHVNVLKE.FAGISLLR THII_ECOLI/28-165 GNIRNVLKHYD.ETLAVVRHWDNIEVRAKDEN...QRLAIRDALTRIP..........GIHHILEV..........EDVPFTDMHDIFEKALVQYRDQLEGK.......TFCVRVKRRGKH................DFSSIDVERYVGGGLNQHIE......SARVKLTNPDVTVHLEVEDD.RLLLIKGR THII_MYCGE/32-165 INIKKAFKKLEINNSIVYEFDRIVVFDIKKE....QRAILQELFSFLP..........GISLFFFA...........SQIVREENKLLDLLFNLFKDFN..........SFKLEVKRRDKNF...............AENSSNFKKYLAVKLFEKYQ.......LKGVINNPEIIANIEILKE.HFLVFTER THII_MYCPN/34-167 KNVKQAFKKLSITNPVDYQFDMLVVGEVIST....QRSLLKNLFTRLP..........GLSVCLFA...........LQIPHDEAQLLALLQQVVQSHP..........SFKIEVRRRDKLF...............ACNSSAFKKYLALQLWEKYQ.......LKGKLVDPAITVHVEVTKE.HFLIISES THII_METJA/35-176 KNIIKLLRKYEIDAEVKILH.RKLLVKINTKD...KEDLALKLLKKVA..........GIVSYSPV...........YECPLDINEIVSFAVQIMKKKLKTLNKE..KVTFAVKTKRSYKKF...............PFTSVEVNKKVGEAIVEKLG.......LEVDLENPDIVLGIEILND.GAYIFTEK E7FHT9_PYRFU/25-153 DNIEKILKRKGIPGKTKISR.GRILVD........APNEATNIIAKTP..........GVVSVSPA..........EVMEYEEIPNYLKKTLMGFNPK...........SFKVETQRLDKTF...............LKTSLEINKEIGEFVVKEFG.......WKVDLENPELVIGIEIIDG.KAYVFFEK O59053_PYRHO/28-167 NNIREALVTEEVPYKEIFSRHGRIIVKTN......SPKEAANVLVRVF..........GIVSISPA...........MEVEASLEKINRTALLMFRKKAKEVGKE..RPKFRVTARRITKEF...............PLDSLEIQAKVGEYILNNEN.......CEVDLKNYDIEIGIEIMQG.KAYIYTEK #=GR O59053_PYRHO/28-167 SS HHHHHHHHHTT---SEEEEETTEEEEE-S......-HHHHHHHHTTST..........TEEEEEEE...........EEEES-HHHHHHHHHHHHHHHHHHHT-S..S-EEEEEEEESSS-S...............SS-HHHHHHHHHHHHHCCSS.......-EE-SSS-SEEEEEEEETT.EEEEES-- Q9V0F6_PYRAB/28-167 NNIREALLDEGIEYKEIFAKHGRIIVRTN......KAREASNALVRVF..........GIVSLSPA...........MEVEASLEKINKTALTLFRRKVRELGLD..RPRFRVTARRITKEF...............PLNSLEIQAKVGEFILNNED.......CTVDLHEYDVEVGIEIMEG.KAYIFTEK THII_TREPA/31-168 RNLTLMLRSINPHVTVRAGR.....LYLSVPASFEAQTTAEQALSYLL..........GITGWAAA...........TACPKTMEAITRCAHAEATLAAREGKR.....TFRIEARRADKRF...............CRTSSEIAREVGAVIHQSGA.......LSVDLHHPDVVIFIEVRER.EAFLYGAR THII_ARCFU/29-153 EAIKRA......TGMRVRRKYGRIEVE........YREGLESRMAKIP..........GIRYFGVG...........FKTELNLESIKKAALSVLPESFK.........TFKVDTSRSNKNF...............PMNSVEVNRKVGAFIVEKTG.......KKVDLTNPDVTVWIEICEK.EAYVYSKR THII_BACSU/29-165 QNIRLVLKDY..PNLKYFSNRDRMTITLNGE....DPEALFPHLKQVF..........GIQSFSLA...........IKCDSRLDDIKATALKAIKDQYKPGD......TFKVATKRAYKQF...............ELDTNQMNAEIGGHILRNTE......GLTVDVRNPDIPLRIEIREE.ATFLTIRD THII_THEMA/30-162 RNIERV......TGMKVKRQWGRFLIPID......ENVTLDDKLKKIF..........GIQNFSKG...........FLVSHDFEEVKKYSLIAVKEKLEKGNY....RTFKVQAKKAYKEY...............KKGVYEINSELGALILKNFK......ELSVDVRNPDFVLGVEVRPE.GVLIFTDR #=GR THII_THEMA/30-162 SS HHHHHH......H-S--EEETTEEEEEE-......TT---HHHHHTST..........T--EEEEE...........EEE-S-HHHHHHHHHHHHHHHHHHS--....-EEEEEEEESSTTS...............SS-HHHHHHHHHHHHHHH-T......T-EE-SSS-SEEEEEEEETT.EEEEEEEE THII_AERPE/30-166 RALEESLAAAGVEAEVERLQ.GRVLVRLRSPG...DAAAAARASARVF..........GVKSVSPA..........VEVEYSGIEDLAEKAAEFFGERVRGR.......VFRVRARRSGVE................GFTSKDVERLLGKLLLERGA.......GGVDLEKPEYTAYVEVRGR.RAYFFDTI THII_METTH/32-165 HNIKSAF......SCRAELRHGRIFIFPE......DMDEALDRLSKIF..........GIVSFSPA...........VTAETGFDSIEDSLREYIHELRSEGLLTS.RTPFAIRCRRVGEH................DFTSQEMAAFAGSVVVGEIG.......APVDLGNPDLEIHLEIRED.ETYIYHRV Q21503_CAEEL/58-198 DNLYMVFYEETIE.KLSEMQKEDALKTIQSQISFCNWKLAIEAYQLAR............................GNAINGGSEKILKQIQQFKKDRIYSEVTDD.SPKFRVTCKRCGEKEI.............HKFSSMDAASKFGAEINNAFG.......WKCSVKEFDIEVVLRIDRN.NMTVMMAL PUS10_AERPE/24-198 GRLFARLGRGWSNRERGEAVKRVLVMELHRRVLEGDEAALKTLVSAAPNIGE..VARDVVEHLSPGSYR...EGGPCAVCGGRLESVIASAVEEGYRLLRAYDI....ERFVVGVRLERGVAMAEEEVKLAAGAGYGESIKAEIRREVGKLLVSRGG.......VTVDFDSPEATLMVEFPGG.GVDIQVNS O73996_PYRHO/37-175 GRMFAKLGKGT.NEERGKAIRLILSMELNREVKEPENCEL....................................CQGIFRRMNELLDLVRNAVEDYEFQ........TFQIGSRFPKDILEKEKKIWEEFGITTGEPINREFNRELGKLFAKVTG.......KIPNRERPDIVIIVEPFSS.KVELQVNP Q9V0E5_PYRAB/21-158 GRMFAKLGKGT.NEERGRAIRLVLSMEINKEIEEPKNCEI....................................CNGIFKRMSEFLNLALEAVKDYEFE........TFRIGSRFPREILEREKEIWEKFSITTGEPINREFNRELGKMFAKATG........KVPSERPDIVIILDPFSR.KVELQVNP O27377_METTH/24-159 GRHFVDLVEGPGNRLRGEKLQKKFSLKLSGP.............................................CMICGDVFDRIDEAAGMVKEKVDELGLEY...SSVLVGTRLPPKMVELDDEIR.KRLGIQTEGLKRDLNRELGKRVVKLLG.......CSAEFEDPDLVVMVDFRGDIRVWIQINP PUS10_ARCFU/5-118 RECYGIIGEGVVAEK.............................................................CEACCNAFDRVEEFAEEIVKKMSEYEFE.....TFNVGSRVWGSLKALQEYL...SLKGIEYEIKQRFNTKLARAIEEKTG........SKRTLNPDITVLFDLETF.TFELQIRP Q9YCV6_AERPE/13-149 ARIEEE..APHLRARPIPRGFKGLVLVYGCRDPEADARLILERVVEAD.............RVLVV..........HAVSRASLEEMAAAAAEAARGRIGGGE......CFAVRTTRRGSH................GYTSVDVNVVVGDAVRRATG.......ACVNLESPDKVVAVEIIQD.LALISIYP O28057_ARCFU/16-147 SHIKDA..IGDVEIEIRPSGFLGLLIVHC.......DESLKEKLEEIP..........EIETIIPV..........LVECEAKLDEILSKAEVVAEKVKGAR.......TFAIRTKRRGTH................DFTSLDVNLDLGDRIRELTG.......CEVDLNFPDKAVYVEIIGK.RAFIGVID Y421_METJA/17-148 NNLKEI..VDDFNYIVSPDGYQGIVIVES.......DEDIEDKILQIP..........EVERVLKV..........YFETETDFDKIVNLAEKIKDYIKEDE.......TFAVETKKRGKH................DFSSTDINIVLGAKIKDLTN.......ASVDLNNPDKVVHVEVFKN.KTYVSITP Q9V2I9_PYRAB/17-149 NYIKEV..LPEAKVTIAPGGYPGLIIVES......EDEKAMEKILEVP..........EVEKVFPV..........LIEVPATLDDIKNAAEEIVKHIKEGE.......TFAVRTKKRGKK................DYSSVDVNVVLGARIKDLTN.......AEVNLSYPDKVVQVEIIGD.KAYISVIP Q9Y954_AERPE/23-165 ASFLPYREYKDVAVEDLRYALGEVYIIATRMNVIFARASYEDPLELRRRLERRLPEDTPVLRVIPV..........MRIVPAEVEDVKKAVHSLLATQKPG........SFAIRLEARLLREG.............REIPRMEAVKIIAEGVNR...........SVDLGRPDILVLIKPFRL.......RE TAN1_YEAST/99-259 GKDLSSGETKKKDPLAFIDLNCECVTFCKTRKPIVPEEFVLSIMKDLADPKNMVKRTRYVQKLTPI..........TYSCNAKMEQLIKLANLVIGPHFHDPSNVKKNYKFAVEVTRRNFN................TIERMDIINQVVKLVNKEGSE....FNHTVDLKNYDKLILVECFKS.NIGMCVVD YB0A_SCHPO/90-239 KEINSLQKKNKKELLTPIMLDMPCVYFVKTRPPIDPVRLVEFTCEVGKTKK....MTRYTQRLIPI..........VRTTGVSLDDLEELAKSLIDPLFHEGQEG..IKEFAVQANIRNHT................VLKKDDIYRTVARIVGKQHM.........VDLKNFKLLILVQVIKN.IIGISIVQ O61900_CAEEL/101-251 PKPGNFVKKERRCIQRPTGVKNCIFVSVKNANIQLLAEKMVELTQKAPR.......CRFLQRVYPV..........EHTLAVDLSKMNEVLMKVISDTLKADGTGK.LPTYSVEFKARNND................SVAKNSVLQMVDDAVCALAP......TARVSLNHADVTFFVQVSRT.TIMVGVCR O60362_HUMAN/4-143 RRFQSV..........ESGANNVVFIRTLGIEPEKLVHHILQDMYKTKKK.....KTRVILRMLPI..........SGTCKAFLEDMKKYAETFLEPWFKAPNK....GTFQIVYKSRNNS................HVNREEVIRELAGIVCTLNS......ENKVDLTNPQYTVVVEIIKA.VCCLSVVK #=GC SS_cons HHHHHHHHHTT.H-SEEEEETTEEEEECTEEEEEETHHHHHHHHHTST..........TECEEEEE.........EEEEEESSHHHHHHHHHHHHHHHHHHCT-S..S-EEEEEEEESSSTS.............SHSSHHHHHHHHHHHHHHCCTT......T-EE-SSS-SEEEEEEEETT.EEEEEEEC #=GC seq_cons pclpphh.t.thphphh.tthttlhlhhst.....ttptltphhthh...........hl.ph..h...........hts.tsh-clhctstplhpcphht........oFtVcscptspp................phsuh-lpctlGphlhcphs........pVcLppPDllltlElhpp.pshltlpp //