Summary: HEAT repeat
This is the Wikipedia entry entitled "HEAT repeat domain". More...
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HEAT repeat domain Edit Wikipedia article
Structure of the protein phosphatase 2A PR65/A subunit revealing the conformation of its 15 tandemly repeated HEAT motifs.
The HEAT repeat domain is a solenoid protein domain found in a number of cytoplasmic proteins including the four that the give rise to the acronym HEAT (Huntingtin, elongation factor 3 (EF3), protein phosphatase 2A (PP2A), and the yeast kinase TOR1). HEAT repeats form rod-like helical structures which are involved in intracellular transport; they are structurally related to armadillo repeats. The nuclear transport protein importin beta contains 19 HEAT repeats.
- Groves MR, Hanlon N, Turowski P, Hemmings BA, Barford D (January 1999). "The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs". Cell 96 (1): 99â€“110. doi:10.1016/S0092-8674(00)80963-0. PMID 9989501.
- Andrade MA, Bork P (October 1995). "HEAT repeats in the Huntington's disease protein". Nat. Genet. 11 (2): 115â€“6. doi:10.1038/ng1095-115. PMID 7550332.
- Eukaryotic Linear Motif resource motif class LIG_PIKK_1
- Eukaryotic Linear Motif resource motif class DOC_PIKK_1
|This protein-related article is a stub. You can help Wikipedia by expanding it.|
HEAT repeat Provide feedback
The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see PF00514).
Groves MR, Hanlon N, Turowski P, Hemmings BA, Barford D; , Cell 1999;96:99-110.: The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. PUBMED:9989501 EPMC:9989501
Internal database links
|SCOOP:||Dopey_N IFRD RTP1_C1 Proteasom_PSMB DUF2454 V-ATPase_H_C DUF3554 CLASP_N Cnd1 Cnd3 Vac14_Fab1_bd Cohesin_HEAT Ecm29 DUF4042 HEAT_EZ HEAT_2 RasGEF_N_2 RICTOR_V NopRA1|
|Similarity to PfamA using HHSearch:||Arm V-ATPase_H_C Cnd1 Vac14_Fab1_bd Cohesin_HEAT DUF4042 HEAT_EZ HEAT_2 HEAT_2 RasGEF_N_2|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR000357
The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins, including the four name-giving proteins huntingtin, elongation factor 3 (EF3), the 65 Kd alpha regulatory subunit of protein phosphatase 2A (PP2A) and the yeast PI3-kinase TOR1 [PUBMED:7550332]. Arrays of HEAT repeats consists of 3 to 36 units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that many HEAT repeat-containing proteins are involved in intracellular transport processes.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||protein binding (GO:0005515)|
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
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Tetratricopeptide-like repeats are found in a numerous and diverse proteins involved in such functions as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding.
The clan contains the following 127 members:Adaptin_N Alkyl_sulf_dimr ANAPC3 ANAPC5 API5 Arm Arm_2 Arm_3 Avirulence BTAD CAS_CSE1 ChAPs CLASP_N Clathrin Clathrin-link Clathrin_propel Cnd1 Cnd3 Coatomer_E Cohesin_HEAT Cohesin_load COPI_C CRM1_C Cse1 DNA_alkylation Drf_FH3 Drf_GBD DUF1822 DUF2225 DUF3385 DUF3458 DUF3808 DUF3856 DUF4042 DUF924 EST1 EST1_DNA_bind FAT Fis1_TPR_C Fis1_TPR_N Foie-gras_1 GUN4_N HAT HEAT HEAT_2 HEAT_EZ HEAT_PBS HemY_N IBB IBN_N IFRD KAP Leuk-A4-hydro_C LRV LRV_FeS MA3 MIF4G MIF4G_like MIF4G_like_2 Mo25 MRP-S27 NARP1 Neurochondrin Nipped-B_C Nro1 NSF Paf67 ParcG PC_rep PHAT PI3Ka PknG_TPR PPP5 PPR PPR_1 PPR_2 PPR_3 PPTA Proteasom_PSMB PUF Rab5-bind Rapsyn_N RPN7 Sel1 SHNi-TPR SNAP SPO22 SRP_TPR_like ST7 Suf SusD SusD-like SusD-like_2 SusD-like_3 TAF6_C TAtT Tcf25 TOM20_plant TPR_1 TPR_10 TPR_11 TPR_12 TPR_14 TPR_15 TPR_16 TPR_17 TPR_18 TPR_19 TPR_2 TPR_20 TPR_21 TPR_3 TPR_4 TPR_5 TPR_6 TPR_7 TPR_8 TPR_9 Upf2 V-ATPase_H_C V-ATPase_H_N Vac14_Fab1_bd Vitellogenin_N Vps39_1 W2 Xpo1 YfiO
We make a range of alignments for each Pfam-A family:
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
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Curation and family details
|Seed source:||Reference |
|Number in seed:||464|
|Number in full:||2799|
|Average length of the domain:||30.60 aa|
|Average identity of full alignment:||27 %|
|Average coverage of the sequence by the domain:||3.28 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||18|
|Download:||download the raw HMM for this family|
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There are 5 interactions for this family. More...
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the HEAT domain has been found. There are 55 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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