Summary: Somatostatin/Cortistatin family
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Somatostatin family Edit Wikipedia article
The Somatostatin family is a protein family with somatostatin as titular member, a hormone which inhibits the release of the pituitary somatotropin (growth hormone), and inhibits the release of glucagon and insulin from the pancreas of fasted animals. Cortistatin is a cortical neuropeptide with neuronal depressant and sleep-modulating properties.
Human proteins from this family
Somatostatin/Cortistatin family Provide feedback
Members of this family are hormones. Somatostatin inhibits the release of somatotropin. Cortistatin is a peptide that is related to the Somatostatins that is found to depresses neuronal electrical activity but, unlike somatostatin, induces low-frequency waves in the cerebral cortex and antagonises the effects of acetylcholine on hippocampal and cortical measures of excitability .
de Lecea L, Criado JR, Prospero-Garcia O, Gautvik KM, Schweitzer P, Danielson PE, Dunlop CL, Siggins GR, Henriksen SJ, Sutcliffe JG; , Nature 1996;381:242-245.: A cortical neuropeptide with neuronal depressant and sleep-modulating properties. PUBMED:8622767 EPMC:8622767
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR018142Somatostatin inhibits the release of the pituitary growth hormone, somatotropin and inhibits the release of glucagon and insulin from the pancreas of fasted animals. Cortistatin is a cortical neuropeptide with neuronal depressant and sleep-modulating properties [PUBMED:8622767].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||extracellular region (GO:0005576)|
|Molecular function||hormone activity (GO:0005179)|
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Curation and family details
|Seed source:||Pfam-B_1891 (release 6.4)|
|Number in seed:||5|
|Number in full:||165|
|Average length of the domain:||17.70 aa|
|Average identity of full alignment:||81 %|
|Average coverage of the sequence by the domain:||16.29 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||10|
|Download:||download the raw HMM for this family|
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