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10  structures 164  species 0  interactions 5839  sequences 94  architectures

Family: Dirigent (PF03018)

Summary: Dirigent-like protein

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Dirigent-like protein Provide feedback

This family contains a number of proteins which are induced during disease response in plants. Members of this family are involved in lignification.

Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR004265

Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism [ PUBMED:27756822 , PUBMED:19946920 ]. This family also includes homologue DRR206 (disease resistance response protein 206). DRR206 is induced by the metabolite pinoresinol monoglucoside and is involved in phytoalexin (lignan) biosynthesis as a defense response [ PUBMED:25457488 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan AOC_barrel (CL0650), which has the following description:

This superfamily was built based on the ECOD classification. According to SCOP this superfamily has a beta barrel topology with 8 strands.

The clan contains the following 5 members:

Allene_ox_cyc AOC_like Dirigent DUF3224 DUF3237

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(237)
Full
(5839)
Representative proteomes UniProt
(8360)
RP15
(507)
RP35
(3121)
RP55
(4899)
RP75
(6412)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(237)
Full
(5839)
Representative proteomes UniProt
(8360)
RP15
(507)
RP35
(3121)
RP55
(4899)
RP75
(6412)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(237)
Full
(5839)
Representative proteomes UniProt
(8360)
RP15
(507)
RP35
(3121)
RP55
(4899)
RP75
(6412)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_835 (release 6.4)
Previous IDs: disease_resp;
Type: Family
Sequence Ontology: SO:0100021
Author: Griffiths-Jones SR
Number in seed: 237
Number in full: 5839
Average length of the domain: 136.60 aa
Average identity of full alignment: 28 %
Average coverage of the sequence by the domain: 65.22 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 29.1 29.1
Trusted cut-off 29.1 29.1
Noise cut-off 28.9 28.9
Model length: 149
Family (HMM) version: 16
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Dirigent domain has been found. There are 10 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0V282 View 3D Structure Click here
A0A0P0V296 View 3D Structure Click here
A0A0P0V4W6 View 3D Structure Click here
A0A0P0WG65 View 3D Structure Click here
A0A0P0X9I7 View 3D Structure Click here
A0A0P0XL32 View 3D Structure Click here
A0A0P0XSY5 View 3D Structure Click here
A0A0P0Y0F7 View 3D Structure Click here
A0A0P0Y0H1 View 3D Structure Click here
A0A0P0Y233 View 3D Structure Click here
A0A0P0Y725 View 3D Structure Click here
A0A0P0Y7F4 View 3D Structure Click here
A0A0P0Y810 View 3D Structure Click here
A0A0P0Y8E1 View 3D Structure Click here
A0A0R0HFI5 View 3D Structure Click here
A0A0R0HTQ0 View 3D Structure Click here
A0A0R0I0T2 View 3D Structure Click here
A0A0R0IJI0 View 3D Structure Click here
A0A0R0KEQ2 View 3D Structure Click here
A0A0R0KER8 View 3D Structure Click here
A0A0R0KLM2 View 3D Structure Click here
A0A0R0LGP0 View 3D Structure Click here
A0A0R4J2V8 View 3D Structure Click here
A0A1D6EHC8 View 3D Structure Click here
A0A1D6F1Q6 View 3D Structure Click here
A0A1D6FA16 View 3D Structure Click here
A0A1D6H8X2 View 3D Structure Click here
A0A1D6HR37 View 3D Structure Click here
A0A1D6HR38 View 3D Structure Click here
A0A1D6HR39 View 3D Structure Click here
A0A1D6HR40 View 3D Structure Click here
A0A1D6IKR5 View 3D Structure Click here
A0A1D6IKR6 View 3D Structure Click here
A0A1D6JH94 View 3D Structure Click here
A0A1D6JNH0 View 3D Structure Click here
A0A1D6KIE5 View 3D Structure Click here
A0A1D6KIE6 View 3D Structure Click here
A0A1D6KQJ1 View 3D Structure Click here
A0A1D6L3I8 View 3D Structure Click here
A0A1D6L8T0 View 3D Structure Click here
A0A1D6LH71 View 3D Structure Click here
A0A1D6LHB1 View 3D Structure Click here
A0A1D6ML65 View 3D Structure Click here
A0A1D6PDC4 View 3D Structure Click here
A0A1D6QHS4 View 3D Structure Click here
A0A1P8BDN2 View 3D Structure Click here
A3BFT9 View 3D Structure Click here
B4F7S2 View 3D Structure Click here
B4FV87 View 3D Structure Click here
B4FVX8 View 3D Structure Click here
B4G233 View 3D Structure Click here
B4G256 View 3D Structure Click here
B6T6D2 View 3D Structure Click here
B6T8I3 View 3D Structure Click here
B6TGG4 View 3D Structure Click here
B6TQI8 View 3D Structure Click here
B6U4J7 View 3D Structure Click here
B7ZZ04 View 3D Structure Click here
C0HFQ1 View 3D Structure Click here
C0P6L6 View 3D Structure Click here
C0PDX9 View 3D Structure Click here
C6SWG8 View 3D Structure Click here
C6SX05 View 3D Structure Click here
C6SZX1 View 3D Structure Click here
C6TAH7 View 3D Structure Click here
C6TDG4 View 3D Structure Click here
F4J4N3 View 3D Structure Click here
F4JDF3 View 3D Structure Click here
F4JUF8 View 3D Structure Click here
I1J7J0 View 3D Structure Click here
I1J7J2 View 3D Structure Click here
I1J7J5 View 3D Structure Click here
I1JFU5 View 3D Structure Click here
I1JL51 View 3D Structure Click here
I1JL52 View 3D Structure Click here
I1JNN6 View 3D Structure Click here
I1JNN8 View 3D Structure Click here
I1JNP0 View 3D Structure Click here
I1JVV9 View 3D Structure Click here
I1JWH7 View 3D Structure Click here
I1K6C3 View 3D Structure Click here
I1KMR1 View 3D Structure Click here
I1L4R3 View 3D Structure Click here
I1L712 View 3D Structure Click here
I1LK76 View 3D Structure Click here
I1LK78 View 3D Structure Click here
I1LK80 View 3D Structure Click here
I1LPN3 View 3D Structure Click here
I1LRP2 View 3D Structure Click here
I1N391 View 3D Structure Click here
I1N9C0 View 3D Structure Click here
I1N9C1 View 3D Structure Click here
I1N9C2 View 3D Structure Click here
I1N9C3 View 3D Structure Click here
I1N9C4 View 3D Structure Click here
I1NEJ1 View 3D Structure Click here
I1NEJ2 View 3D Structure Click here
K7KCT9 View 3D Structure Click here
K7KRG6 View 3D Structure Click here
K7KYC2 View 3D Structure Click here
K7KYC3 View 3D Structure Click here
K7L1Z4 View 3D Structure Click here
K7L4H3 View 3D Structure Click here
K7L8W9 View 3D Structure Click here
K7LQI3 View 3D Structure Click here
K7LTE1 View 3D Structure Click here
K7MJQ7 View 3D Structure Click here
K7MV88 View 3D Structure Click here
K7TF29 View 3D Structure Click here
K7TN69 View 3D Structure Click here
K7TXJ5 View 3D Structure Click here
K7U735 View 3D Structure Click here
K7UPI1 View 3D Structure Click here
K7V3N7 View 3D Structure Click here
K7V6J0 View 3D Structure Click here
O80630 View 3D Structure Click here
O82498 View 3D Structure Click here
Q0D465 View 3D Structure Click here
Q10N68 View 3D Structure Click here
Q2QVJ4 View 3D Structure Click here
Q2QWD7 View 3D Structure Click here
Q2R0H3 View 3D Structure Click here
Q2R0I1 View 3D Structure Click here
Q2R8V6 View 3D Structure Click here
Q2R8V8 View 3D Structure Click here
Q2R8W3 View 3D Structure Click here
Q306J3 View 3D Structure Click here
Q53NP4 View 3D Structure Click here
Q53NP7 View 3D Structure Click here
Q53NP8 View 3D Structure Click here
Q53NP9 View 3D Structure Click here
Q53NQ2 View 3D Structure Click here
Q53NQ9 View 3D Structure Click here
Q66GI2 View 3D Structure Click here
Q67YM6 View 3D Structure Click here
Q6ATP8 View 3D Structure Click here
Q6H838 View 3D Structure Click here
Q6ZDJ2 View 3D Structure Click here
Q7EXY2 View 3D Structure Click here
Q7G3R5 View 3D Structure Click here
Q7Y225 View 3D Structure Click here
Q84TH6 View 3D Structure Click here
Q8GS08 View 3D Structure Click here
Q8GS22 View 3D Structure Click here
Q8GVG8 View 3D Structure Click here
Q8H042 View 3D Structure Click here
Q8H3X4 View 3D Structure Click here
Q8H5S2 View 3D Structure Click here
Q8L453 View 3D Structure Click here
Q8L532 View 3D Structure Click here
Q8LH34 View 3D Structure Click here
Q8LMF1 View 3D Structure Click here
Q8S1R2 View 3D Structure Click here
Q8S5Q4 View 3D Structure Click here
Q943Q0 View 3D Structure Click here
Q94LE8 View 3D Structure Click here
Q9C523 View 3D Structure Click here
Q9C891 View 3D Structure Click here
Q9FI66 View 3D Structure Click here
Q9FIG6 View 3D Structure Click here
Q9FIG7 View 3D Structure Click here
Q9LID5 View 3D Structure Click here
Q9LQQ0 View 3D Structure Click here
Q9M3C8 View 3D Structure Click here
Q9SH66 View 3D Structure Click here
Q9SIA8 View 3D Structure Click here
Q9SKQ2 View 3D Structure Click here
Q9SS03 View 3D Structure Click here
Q9SUQ8 View 3D Structure Click here
Q9T017 View 3D Structure Click here
Q9T019 View 3D Structure Click here
Q9T0H8 View 3D Structure Click here