Summary: ABC1 family
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ABC1 family Provide feedback
This family includes ABC1 from yeast  and AarF from E. coli . These proteins have a nuclear or mitochondrial subcellular location in eukaryotes. The exact molecular functions of these proteins is not clear, however yeast ABC1 suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex  and E. coli AarF is required for ubiquinone production . It has been suggested that members of the ABC1 family are novel chaperonins . These proteins are unrelated to the ABC transporter proteins.
Bousquet I, Dujardin G, Slonimski PP; , EMBO J 1991;10:2023-2031.: ABC1, a novel yeast nuclear gene has a dual function in mitochondria: it suppresses a cytochrome b mRNA translation defect and is essential for the electron transfer in the bc 1 complex. PUBMED:1648478 EPMC:1648478
Macinga DR, Cook GM, Poole RK, Rather PN; , J Bacteriol 1998;180:128-135.: Identification and characterization of aarF, a locus required for production of ubiquinone in Providencia stuartii and Escherichia coli and for expression of 2'-N-acetyltransferase in P. stuartii. PUBMED:9422602 EPMC:9422602
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR004147
This entry represents a domain found in Escherichia coli UbiB, known in Providencia stuartii as Aarf, which is required for the first monooxygenase step in ubiquinone (CoQ) biosynthesis [PUBMED:10960098, PUBMED:9422602]. Some proteins with this domain are described as aarF domain-containing protein kinases (ADCKs). This domain is also found in yeast ABC1 proteins (SWISSPROT) required for function of the mitochondrial bc1 complex [PUBMED:1648478], in which CoQ functions as an essential cofactor.
The function of these proteins is not clear. Along with ABC1, UbiB is part of a large family of proteins that contain motifs found in eukaryotic-type protein kinases [PUBMED:9799791], but is not known if they have kinase activity and how this would relate to their requirement for the monoxygenase step in CoQ synthesis. A role in regulation of this step by phosphorylation has been speculated [PUBMED:10960098].
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This superfamily includes the Serine/Threonine- and Tyrosine- protein kinases as well as related kinases that act on non-protein substrates.
The clan contains the following 19 members:ABC1 APH APH_6_hur Choline_kinase DUF1679 DUF2252 EcKinase Fructosamin_kin Kdo Kinase-like PIP49_C Pkinase Pkinase_Tyr Pox_ser-thr_kin RIO1 Seadorna_VP7 UL97 WaaY YrbL-PhoP_reg
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Curation and family details
|Seed source:||Pfam-B_339 (release 6.5)|
|Number in seed:||32|
|Number in full:||5521|
|Average length of the domain:||116.90 aa|
|Average identity of full alignment:||31 %|
|Average coverage of the sequence by the domain:||21.56 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||11|
|Download:||download the raw HMM for this family|
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