Summary: Urea transporter
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Urea transporter Provide feedback
Members of this family transport urea across membranes. The family includes a bacterial homologue Q9S408.
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR004937
Proteins in this entry include low-affinity urea transporters found in the erythrocytes and kidneys of higher organisms. The erythrocyte proteins carry the clinically important Kidd (Jk) blood group antigens which help determine blood type. The two commonest forms are Jk(a) and Jk(b), which arise from a single residue variation at position 280; aspartate in Jk(a) and asparagine in Jk(b) [PUBMED:9215669]. A much rarer phenotype, Jk(null), arises when the protein is not expressed on the erythrocyte surface, and is linked to a urine-concentrating defect [PUBMED:1498276]. The Kidd blood group is clinically significant as Jk antibodies can cause acute transfusion reactions and haemolytic disease of the newborn (HDN), where the mother's body creates antibodies against the foetal blood cells. HDN associated with Jk antibodies is generally mild, but fatal cases can occur [PUBMED:16479082].
The bacterial proteins in this entry also appear to be involved in urea transport, promoting its entry into the cell [PUBMED:12180933]. This uptake of urea can be advantageous for bacteria as its hydrolysis by urease generates ammonium which is an efficient source of nitrogen and, through its buffering capacity, can also provide resistance to acidic conditions.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||integral to membrane (GO:0016021)|
|Molecular function||urea transmembrane transporter activity (GO:0015204)|
|Biological process||urea transmembrane transport (GO:0071918)|
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Curation and family details
|Seed source:||Pfam-B_3193 (release 6.5)|
|Number in seed:||26|
|Number in full:||784|
|Average length of the domain:||275.00 aa|
|Average identity of full alignment:||32 %|
|Average coverage of the sequence by the domain:||84.53 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the UT domain has been found. There are 6 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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