Summary: Bacterial lipid A biosynthesis acyltransferase
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Bacterial lipid A biosynthesis acyltransferase Provide feedback
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Internal database links
|Similarity to PfamA using HHSearch:||Acyltransferase|
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This tab holds annotation information from the InterPro database.
InterPro entry IPR004960
Bacterial lipopolysachharides (LPS) are glycolipids that make up the outer monolayer of the outer membranes of most Gram-negative bacteria. Though LPS moleculesare variable, they all show the same general features: an outer polysaccharide which is attached to the lipid component, termed lipid A [PUBMED:9791168]. The polysaccharide component consists of a variable repeat-structure polysaccharide known as the O-antigen, and a highly conserved short core oligosaccharide which connects the O-antigen to lipid A. Lipid A is a glucosamine-based phospholipid that makes up the membrane anchor region of LPS [PUBMED:12045108]. The structure of lipid A is relatively invariant between species, presumably reflecting its fundamental role in membrane integrity. Recognition of lipid A by the innate immune system can lead to a response even at picomolar levels. In some genera, such as Neisseria and Haemophilus, lipooligosaccharides (LOS) are the predominant glycolipids [PUBMED:8894399]. These are analogous to LPS except that they lack O-antigens, with the LOS oligosaccharide structures limited to 10 saccharide units.
The bacterial lipid A biosynthesis protein, or lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase EC, transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA during lipopolysaccharide core biosynthesis [PUBMED:2203778].
|Cellular component||integral to membrane (GO:0016021)|
|Molecular function||transferase activity, transferring acyl groups (GO:0016746)|
|Biological process||lipopolysaccharide core region biosynthetic process (GO:0009244)|
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Curation and family details
|Seed source:||Pfam-B_1803 (release 6.5)|
|Number in seed:||13|
|Number in full:||5234|
|Average length of the domain:||280.50 aa|
|Average identity of full alignment:||24 %|
|Average coverage of the sequence by the domain:||90.64 %|
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build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
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