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44  structures 682  species 0  interactions 4272  sequences 89  architectures

Family: PAE (PF03283)

Summary: Pectinacetylesterase

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Pectinacetylesterase Provide feedback

No Pfam abstract.

This tab holds annotation information from the InterPro database.

InterPro entry IPR004963

This family includes protein Notum from animals and pectinacetylesterase (PAE) from plants. Notum is a carboxylesterase that removes an essential palmitoleate moiety from Wnt proteins. Notum constitutes the first known extracellular protein deacylase [ PUBMED:25731175 , PUBMED:25771893 ]. PAEs catalyse the deacetylation of pectin, a major compound of primary cell walls [ PUBMED:12026180 , PUBMED:25115560 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(52)
Full
(4272)
Representative proteomes UniProt
(9138)
RP15
(567)
RP35
(2044)
RP55
(3665)
RP75
(4801)
Jalview View  View  View  View  View  View  View 
HTML View  View           
PP/heatmap 1 View           

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(52)
Full
(4272)
Representative proteomes UniProt
(9138)
RP15
(567)
RP35
(2044)
RP55
(3665)
RP75
(4801)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(52)
Full
(4272)
Representative proteomes UniProt
(9138)
RP15
(567)
RP35
(2044)
RP55
(3665)
RP75
(4801)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_1589 (release 6.5)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Mifsud W
Number in seed: 52
Number in full: 4272
Average length of the domain: 258.30 aa
Average identity of full alignment: 32 %
Average coverage of the sequence by the domain: 72.23 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.6 26.6
Trusted cut-off 26.7 26.6
Noise cut-off 26.4 26.5
Model length: 356
Family (HMM) version: 15
Download: download the raw HMM for this family

Species distribution

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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PAE domain has been found. There are 44 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0N7KE80 View 3D Structure Click here
A0A0P0WHB0 View 3D Structure Click here
A0A0R0FCS4 View 3D Structure Click here
A0A0R0FML8 View 3D Structure Click here
A0A0R0GWV8 View 3D Structure Click here
A0A0R0I579 View 3D Structure Click here
A0A0R0J2R7 View 3D Structure Click here
A0A1D6G7A0 View 3D Structure Click here
A0A1D6HH87 View 3D Structure Click here
A0A1D6IXV8 View 3D Structure Click here
A0A1D6K689 View 3D Structure Click here
A0A1D6LVW0 View 3D Structure Click here
A0A1D6MMW2 View 3D Structure Click here
A0A1D6MS67 View 3D Structure Click here
A0A1D6MZZ9 View 3D Structure Click here
A0A1D6N558 View 3D Structure Click here
A0A1D6N558 View 3D Structure Click here
A0A1D6N558 View 3D Structure Click here
A0A1D6N558 View 3D Structure Click here
A0A1D6NME3 View 3D Structure Click here
A0A1D6P731 View 3D Structure Click here
B4F9X6 View 3D Structure Click here
B4FVG6 View 3D Structure Click here
B9DFR3 View 3D Structure Click here
C5H5C4 View 3D Structure Click here
D3ZXI3 View 3D Structure Click here
E7F0Z8 View 3D Structure Click here
F4I107 View 3D Structure Click here
F4I839 View 3D Structure Click here
I1JB95 View 3D Structure Click here
I1JQY4 View 3D Structure Click here
I1JR09 View 3D Structure Click here
I1L5A1 View 3D Structure Click here
I1LAU7 View 3D Structure Click here
I1LAY0 View 3D Structure Click here
I1MLY5 View 3D Structure Click here
I1MMH3 View 3D Structure Click here
I1MMH4 View 3D Structure Click here
I1MMH5 View 3D Structure Click here
I1MS08 View 3D Structure Click here
I1NBJ7 View 3D Structure Click here
I1NBM1 View 3D Structure Click here
I1NET3 View 3D Structure Click here
I1NGU7 View 3D Structure Click here
K7K3Z6 View 3D Structure Click here
K7L1F9 View 3D Structure Click here
K7LL20 View 3D Structure Click here
K7MT28 View 3D Structure Click here
K7VC42 View 3D Structure Click here
K7VY73 View 3D Structure Click here
O80731 View 3D Structure Click here
Q0IVV9 View 3D Structure Click here
Q0JAF0 View 3D Structure Click here
Q5JL22 View 3D Structure Click here
Q5JLW5 View 3D Structure Click here
Q66GM8 View 3D Structure Click here
Q69UW6 View 3D Structure Click here
Q6DBP4 View 3D Structure Click here
Q6DFZ6 View 3D Structure Click here
Q6P988 View 3D Structure Click here
Q6YVK6 View 3D Structure Click here
Q84JS1 View 3D Structure Click here
Q8R116 View 3D Structure Click here
Q940J8 View 3D Structure Click here
Q94D71 View 3D Structure Click here
Q9FH82 View 3D Structure Click here
Q9SFF6 View 3D Structure Click here
Q9SR22 View 3D Structure Click here
Q9SR23 View 3D Structure Click here
Q9VUX3 View 3D Structure Click here