Summary: Insect pheromone-binding family, A10/OS-D
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This is the Wikipedia entry entitled "Insect pheromone-binding family A10/OS-D". More...
Insect pheromone-binding family A10/OS-D Edit Wikipedia article
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Insect pheromone-binding family, A10/OS-D Provide feedback
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Literature references
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McKenna MP, Hekmat-Scafe DS, Gaines P, Carlson JR; , J Biol Chem 1994;269:16340-16347.: Putative Drosophila pheromone-binding proteins expressed in a subregion of the olfactory system. PUBMED:8206941 EPMC:8206941
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Angeli S, Ceron F, Scaloni A, Monti M, Monteforti G, Minnocci A, Petacchi R, Pelosi P; , Eur J Biochem 1999;262:745-754.: Purification, structural characterization, cloning and immunocytochemical localization of chemoreception proteins from Schistocerca gregaria. PUBMED:10411636 EPMC:10411636
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Pikielny CW, Hasan G, Rouyer F, Rosbash M; , Neuron 1994;12:35-49.: Members of a family of Drosophila putative odorant-binding proteins are expressed in different subsets of olfactory hairs. PUBMED:7545907 EPMC:7545907
External database links
SCOP: | 1n8v |
This tab holds annotation information from the InterPro database.
InterPro entry IPR005055
This entry represents the insect odorant-binding protein A10 and ejaculatory bulb-specific protein 3 (PebIII).
Odorant binding proteins (OBPs) is a class of small (14-20 Kd) water-soluble proteins first discovered in the insect sensillar lymph but also in the mucus of vertebrates, is postulated to mediate the solubilisation of hydrophobic odorant molecules, and thereby to facilitate their transport to the receptor neurons. The product of a gene expressed in the olfactory system of Drosophila melanogaster (Fruit fly), OS-D, shares features common to vertebrate odorant-binding proteins, but has a primary structure unlike odorant-binding proteins [PUBMED:8206941]. OS-D derivatives have subsequently been found in chemosensory organs of phylogenetically distinct insects, including cockroaches, phasmids and moths, suggesting that OS-D-like proteins seem to be conserved in the insect phylum.
Domain organisation
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Alignments
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Seed (126) |
Full (882) |
Representative proteomes | UniProt (2434) |
NCBI (2923) |
Meta (0) |
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RP15 (244) |
RP35 (510) |
RP55 (804) |
RP75 (882) |
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
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Seed (126) |
Full (882) |
Representative proteomes | UniProt (2434) |
NCBI (2923) |
Meta (0) |
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RP15 (244) |
RP35 (510) |
RP55 (804) |
RP75 (882) |
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Raw Stockholm | |||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
Trees
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Curation
Seed source: | Pfam-B_3032 (release 6.6) |
Previous IDs: | none |
Type: | Family |
Sequence Ontology: | SO:0100021 |
Author: |
Mifsud W |
Number in seed: | 126 |
Number in full: | 882 |
Average length of the domain: | 88.80 aa |
Average identity of full alignment: | 38 % |
Average coverage of the sequence by the domain: | 62.30 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 45638612 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 93 | ||||||||||||
Family (HMM) version: | 13 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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Interactions
There is 1 interaction for this family. More...
OS-DStructures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the OS-D domain has been found. There are 9 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.
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