Summary: Prohead core protein serine protease
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Prohead core protein serine protease Provide feedback
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This tab holds annotation information from the InterPro database.
InterPro entry IPR005082
This group of peptidases belongs to MEROPS peptidase family U9 (phage prohead processing peptidase family, clan U-), which play a role in the head assembly of Bacteriophage T4.
The pathway of bacteriophage T4 head assembly begins with the formation of a prohead bound to the bacterial cell membrane which is later converted to the mature, DNA-containing head. During maturation, all but one of the prohead proteins are proteolytically processed by a phage-coded protease which is formed by autocatalytic cleavage of the product of gene 21 (gp21). Protease gp21 has been tentatively located in the centre of the prohead core [PUBMED:3552886].
The peptidases families associated with clan U- have an unknown catalytic mechanism as the protein fold of the active site domain and the active site residues have not been reported.
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This clan includes the serine peptidase assemblin from herpes virus as well as other viral peptidase families predicted to be related .
The clan contains the following 4 members:Peptidase_S21 Peptidase_S77 Peptidase_S78 Peptidase_S78_2
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Number in seed:||2|
|Number in full:||156|
|Average length of the domain:||171.80 aa|
|Average identity of full alignment:||43 %|
|Average coverage of the sequence by the domain:||77.74 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
|Download:||download the raw HMM for this family|
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