!!

Powering down the Pfam website
On October 5th, we will start redirecting the traffic from Pfam (pfam.xfam.org) to InterPro (www.ebi.ac.uk/interpro). The Pfam website will be available at pfam-legacy.xfam.org until January 2023, when it will be decommissioned. You can read more about the sunset period in our blog post.

Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
1260  structures 8905  species 0  interactions 12932  sequences 92  architectures

Family: Ribosomal_S5_C (PF03719)

Summary: Ribosomal protein S5, C-terminal domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Ribosomal protein S5, C-terminal domain Provide feedback

No Pfam abstract.

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR005324

This entry represents the C-terminal of the ribosomal protein S5, which is related to the 30S ribosomal protein S5P from Sulfolobus acidocaldarius ( SWISSPROT ). Ribosomal protein S5 is one of the proteins from the small ribosomal subunit. In Escherichia coli, S5 is known to be important in the assembly and function of the 30S ribosomal subunit. Mutations in S5 have been shown to increase translational error frequencies.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

Loading domain graphics...

Pfam Clan

This family is a member of clan S5 (CL0329), which has the following description:

This superfamily contains a wide range of families that possess a structure similar to the second domain of ribosomal S5 protein.

The clan contains the following 18 members:

ChlI DNA_gyraseB DNA_mis_repair EFG_IV Fae GalKase_gal_bdg GHMP_kinases_N IGPD Lon_C LpxC Morc6_S5 Ribonuclease_P Ribosomal_S5_C Ribosomal_S9 RNase_PH Topo-VIb_trans UPF0029 Xol-1_N

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(454)
Full
(12932)
Representative proteomes UniProt
(48067)
RP15
(2134)
RP35
(6339)
RP55
(12140)
RP75
(19497)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(454)
Full
(12932)
Representative proteomes UniProt
(48067)
RP15
(2134)
RP35
(6339)
RP55
(12140)
RP75
(19497)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(454)
Full
(12932)
Representative proteomes UniProt
(48067)
RP15
(2134)
RP35
(6339)
RP55
(12140)
RP75
(19497)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Finn RD , Griffiths-Jones SR
Number in seed: 454
Number in full: 12932
Average length of the domain: 70.6 aa
Average identity of full alignment: 41 %
Average coverage of the sequence by the domain: 29.55 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.5 21.5
Trusted cut-off 21.5 21.5
Noise cut-off 21.3 21.3
Model length: 71
Family (HMM) version: 18
Download: download the raw HMM for this family

Species distribution

Sunburst controls

Hide

Weight segments by...


Change the size of the sunburst

Small
Large

Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

Generate a FASTA-format file

Clear selection

This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Loading sunburst data...

Tree controls

Hide

The tree shows the occurrence of this domain across different species. More...

Loading...

Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Ribosomal_S5_C domain has been found. There are 1260 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

Loading structure mapping...

AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A044TK27 View 3D Structure Click here
A0A044TMY9 View 3D Structure Click here
A0A044V4D9 View 3D Structure Click here
A0A077YZL2 View 3D Structure Click here
A0A077Z020 View 3D Structure Click here
A0A077ZJB8 View 3D Structure Click here
A0A077ZMU3 View 3D Structure Click here
A0A0D2GI43 View 3D Structure Click here
A0A0D2GUD6 View 3D Structure Click here
A0A0G2K6C1 View 3D Structure Click here
A0A0G2KB28 View 3D Structure Click here
A0A0H3H3V5 View 3D Structure Click here
A0A0J9Y138 View 3D Structure Click here
A0A0J9Y3C2 View 3D Structure Click here
A0A0K0EEA6 View 3D Structure Click here
A0A0K0EIK4 View 3D Structure Click here
A0A0K0IQ58 View 3D Structure Click here
A0A0N4U401 View 3D Structure Click here
A0A0N4UG09 View 3D Structure Click here
A0A0P0X4X0 View 3D Structure Click here
A0A0R4IAB6 View 3D Structure Click here
A0A0U1RVI9 View 3D Structure Click here
A0A146M1R1 View 3D Structure Click here
A0A175WEG1 View 3D Structure Click here
A0A1C1C8N8 View 3D Structure Click here
A0A1C1CDU1 View 3D Structure Click here
A0A1D6GF42 View 3D Structure Click here
A0A1D6GXW0 View 3D Structure Click here
A0A1D8PEV9 View 3D Structure Click here
A0A368UJ29 View 3D Structure Click here
A0A3P7DPS1 View 3D Structure Click here
A0A3P7EX98 View 3D Structure Click here
A0A5K4FAM5 View 3D Structure Click here
A0B9V0 View 3D Structure Click here
A0JZ68 View 3D Structure Click here
A0KF38 View 3D Structure Click here
A0L5Z0 View 3D Structure Click here
A0LIK7 View 3D Structure Click here
A0LRN7 View 3D Structure Click here
A0PXW3 View 3D Structure Click here