# STOCKHOLM 1.0 #=GF ID BioW #=GF AC PF03744.14 #=GF DE 6-carboxyhexanoate--CoA ligase #=GF AU Bateman A;0000-0002-6982-4660 #=GF SE COG1424 #=GF GA 25.00 25.00; #=GF TC 75.10 75.00; #=GF NC 23.00 20.80; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq #=GF TP Family #=GF RN [1] #=GF RM 1445232 #=GF RT Investigation of the first step of biotin biosynthesis in #=GF RT Bacillus sphaericus. Purification and characterization of the #=GF RT pimeloyl-CoA synthase, and uptake of pimelate. #=GF RA Ploux O, Soularue P, Marquet A, Gloeckler R, Lemoine Y; #=GF RL Biochem J 1992;287:685-690. #=GF DR INTERPRO; IPR005499; #=GF DR SO; 0100021; polypeptide_conserved_region; #=GF CC This family contains the enzyme 6-carboxyhexanoate--CoA ligase #=GF CC EC:6.2.1.14. This enzyme is involved in the first step of biotin #=GF CC synthesis, where it converts pimelate into pimeloyl-CoA [1]. The #=GF CC enzyme requires magnesium as a cofactor and forms a homodimer #=GF CC [1]. #=GF SQ 35 #=GS BIOWF_CORK4/3-263 AC C4LK80.1 #=GS BIOWF_CUTAK/12-247 AC Q6A6M4.1 #=GS BIOW_THEYD/2-244 AC B5YK86.1 #=GS I0IN26_LEPFC/27-281 AC I0IN26.1 #=GS J9ZBA3_LEPFM/16-267 AC J9ZBA3.1 #=GS F6CMT0_DESK7/6-256 AC F6CMT0.1 #=GS BIOW_PELCD/6-251 AC Q3A3Z7.1 #=GS BIOW_METRM/6-255 AC D3E0R7.1 #=GS R6AHK0_9FIRM/3-248 AC R6AHK0.1 #=GS R7CQ42_9FIRM/3-248 AC R7CQ42.1 #=GS R5T2P8_9FIRM/8-253 AC R5T2P8.1 #=GS R5BCC4_9FIRM/3-256 AC R5BCC4.1 #=GS F5YMQ2_TREPZ/3-247 AC F5YMQ2.1 #=GS BIOW_BACPE/8-253 AC D3G0V0.1 #=GS BIOW_BACSU/8-251 AC P53559.1 #=GS BIOW_BACSU/8-251 DR PDB; 5FLG B; 8-251; #=GS BIOW_BACSU/8-251 DR PDB; 5G1F B; 8-251; #=GS BIOW_BACSU/8-251 DR PDB; 5G1F A; 8-251; #=GS BIOW_BACSU/8-251 DR PDB; 5FM0 A; 8-251; #=GS BIOW_BACSU/8-251 DR PDB; 5FLL B; 8-251; #=GS BIOW_BACSU/8-251 DR PDB; 5FLG A; 8-251; #=GS BIOW_BACSU/8-251 DR PDB; 5FM0 B; 8-251; #=GS BIOW_BACSU/8-251 DR PDB; 5FLL A; 8-251; #=GS BIOW_BACLD/7-250 AC Q65ML3.1 #=GS BIOW_META3/3-235 AC A6UWX4.1 #=GS BIOW_METMP/2-243 AC Q6LWX9.1 #=GS D7DUJ0_METV3/10-269 AC D7DUJ0.1 #=GS BIOW_METJA/6-236 AC Q58693.1 #=GS BIOW_PERMH/3-241 AC C0QSH0.1 #=GS B4U8N9_HYDS0/5-238 AC B4U8N9.1 #=GS BIOW_AQUAE/4-238 AC O67575.1 #=GS BIOW_AQUAE/4-238 DR PDB; 5TVA B; 4-238; #=GS BIOW_AQUAE/4-238 DR PDB; 5TV8 B; 4-238; #=GS BIOW_AQUAE/4-238 DR PDB; 5TV6 A; 4-238; #=GS BIOW_AQUAE/4-238 DR PDB; 5TV5 B; 4-238; #=GS BIOW_AQUAE/4-238 DR PDB; 5TV8 A; 4-238; #=GS BIOW_AQUAE/4-238 DR PDB; 5TV5 A; 4-238; #=GS BIOW_AQUAE/4-238 DR PDB; 5TV6 B; 4-238; #=GS BIOW_AQUAE/4-238 DR PDB; 5TVA A; 4-238; #=GS BIOW_THEAH/3-240 AC D3SN37.1 #=GS BIOW_HYDTT/3-240 AC D3DK66.1 #=GS BIOW_STAEQ/2-222 AC Q5HKF3.1 #=GS BIOW_STAA8/2-222 AC Q2FVJ9.1 #=GS F0S3F4_DESTD/5-245 AC F0S3F4.1 #=GS C9LVH2_SELS3/4-238 AC C9LVH2.1 #=GS D4M1V7_9FIRM/7-243 AC D4M1V7.1 #=GS BIOW_FIBSS/4-254 AC C9RPK4.1 #=GS BIOW_DESDA/3-230 AC B8J3V1.1 #=GS D9QAS8_CORP2/4-242 AC D9QAS8.1 #=GS BIOW_CORDI/10-243 AC Q6NGW9.1 #=GS W5Y0Z9_9CORY/9-240 AC W5Y0Z9.1 BIOWF_CORK4/3-263 FSIKMRASARVSSSPSTSDGSSGDHTESRDRADRHISGAERIV...S.ASDIMQTVTELEHRAWT...HSNG.QPDDVVVSVHRVDEDEITHIPALT.......RETRHTHT.....VDDAHRTITEILR.DA............GIRTA...EHALKALTRI.....RGMRGAMLLDADTGERRD....T.KDIRGVRVTALDNDMATGADAAEEMSSSAA.TKPYYCEALTLASKVQYHPAVCAELCISDDPDYTTGYVSTSGR.YVRIENIKPMGSPQGGRVFLV.RGTDD.E...IADCINYLENTAVIV BIOWF_CUTAK/12-247 WSVRMRATGT..................LDDEPYHVSGAESLV...A.PGMIEQTVAGLTQRALA...PGHTVKARQVRVSLDQLDVEPT.IIPALP.......TELKECPD.....PVAARQYFVDVLS.RF.............VPHP...AEALRVLTEG.....PTMRGAAMVEAGTDRRLE....A.DPLRGVRVTKFGDLTESAPGASLA.......HKKHHHEAVLLASKVAAAPGVLAEFCISDDPHYTRGYVCVDGV.YTTVTNVKADGDPNGGRVILV..DTARAD...PTTITTWLENHPVLI BIOW_THEYD/2-244 WSVRMRASKK..................ENNIEKHISGAEGIY...D.YSQIERVLKQLFKRAFE...HSKG.KPDKVVITVERI.NEEIQTVSALP.......VNTFFTNS.....PEEAFCLISEKLS.SI............GISDKAL.FSAFEVIKK......YPMRGATLIDSITGERLE....R.DKTRGIRVSRIHMDKRKRMKLIRQIKNLST.QPQRVIEAITIASKVASYPEVVAELCISDNPDYTIGYIASRDLGYLRITNIKNKGETIGGRAFFV.KTP..CD...IEKLTNYLERKPVLV I0IN26_LEPFC/27-281 FNIRMRASLN......................GKHCSGGEEIL...L.ERNLEEGISRLFKRGLGSAPHHLK.NDLTISIRVDGVAPEHLQRSQLLP.......VRQLHSES.....EETTRSFIRSFLLFSL.........GKISVDQEKSTQKILDCIDSLLKPTANPLWGAILL.SPSGEKIP......VPEEGVRTTHIGMEWKTKEELEASAESNGI.SGRRFPEALMLASKVVAQPLIHLELCISDDPTYTTGYIAAKDIAYIRLPHMKKAGMTGGGRIYLLNRIPDDDE...LTALIAGLKETSVLF J9ZBA3_LEPFM/16-267 FSIRMRAFSG......................EKHLSGGEDLV...E.RSALRDRLLALTEQGLTSSRNQEG.VLPSLNIRVEPVKNSSVLRKTLLP.......VHCLESSS.....HQETLSFLSGVLE.AI............GSRESIDTSSLGRWLNDVLNGTESGLSGASLF.FPDGERWI......PENRGVRVTQFGMVPAIRQTLLEEAKNHPAGSGRRFVDALQIASKVAGLPDFLLELCASDNPEYTTGYIALRNFGYLRLPLLKRAGNSSGGRVILLSRKLDERE...RAHAVSYLSRTPVLF F6CMT0_DESK7/6-256 YSVRMRAAEG.......AAHE.........KGGRHISGAEKIV...P.FDQLAQTIQEMLHRAMN...HPLG.EPDFINIKVERLEPGQIRYIAALP.......LQTVKIKN.....HEQALLCARQLLT.AC............GIQPTAI.ERALELLARGPAPGGQNMRGAVIMDAASGRRLE....P.DPWRGVRVSRMDYTPRAAAELSRLLEPLGL.DHFRVREALALATKVIYA.GTLAEICCSDDPHYTTGYVSSQRFGYVRIPHLKHA.SFKGGRVFFVRARE..IN...LERYISRLQEEPVLI BIOW_PELCD/6-251 YSIRMRSSCD......................ERHISGAENLA...P.AERLHALASAMVRRALA...HDKG.QAEQIFLSIEKVDTADI.VCHGLP......DIRTIRVAS.....VEQGRDAALSMLE.KA............GVNPQAA.RRAMATMARGAAPNGDSMRGAMLVDASTGQRLE....K.DRYRGVRVSRMDLDEQTSVRLKNLLQTAGL.DNPHVREALVLAAKVIHAPGVIAELCWSDDPGYTAGYVAGASLGYVRFPLLKPAGEVRGGRAFFL.SSD..AD...LAQLIPYLERQVVLI BIOW_METRM/6-255 YSIKMRSAKG.......GPHE.........EGGKHISGAERIL...R.EDEIEEELINVYRRAIT...HEKG.KPDFINLKIEAIDEDKILYKKRLN.......IIQHKVSS.....KEEGLKLAKELLI.KN............TVSEEAA.KEGISSIQKLK....ESIHGAMLLDKDSGKRID....D.KGIKGVRVTGIASADIKKYKESLKRDGR...EGLHLEEALILASKIASCKAIVAELCWSDDPSYVIGYVGTKEN.YHRIPILKDKGNPVGGRVFFV.DTSQLNDNYTLEDLIDYLEKQIVLI R6AHK0_9FIRM/3-248 YSVKMRSSLG.......GSHG.........VGGRHISGAERIV...P.EDGLEEQVIAMLRRART...HERG.RADFIQVKVEEIKEKDIMTCPLIP.......LYQMDTRT.....KSEGRKAAKKELL.RI............GVSKAAV.ESAFRELESLT....DSMRGAIVMDAVTGERLD....D.RAERGVRCSNMDCGDTALYEARMAEKGL...GGDHPREALVLASKVAYGPGTVAELCWSDDPDYVTGYVGSKKFGYGRITVMKDMGDPVGGRVFFV.EHG..TD...VARYDDYMQNQVVLV R7CQ42_9FIRM/3-248 YSVKMRSSLG.......GTHG.........KGGRHISGAERIV...S.EDLVDETVISMMRRARE...HERG.CADFIQVKVEEVPDAAVSYCLMLP.......LYQIDTSE.....KSEGHRAAEAELI.RA............GVSPLAA.RRGIASLEALE....DSMRGAIVMDAETGERLD....G.RGEREVRCSNMDSADTAEYEAKMRGKGL...GGDHPREALVLASKVAHGPGTVAELCWSDDPDYVTGYVGSPLHGYGRITVIKDKGDPVGGRVFFV.KHG..TD...VALYEDYMQNQTVLV R5T2P8_9FIRM/8-253 YSVKMRSSLG.......GAHG.........VGGQHISGAERIV...T.KNSVEQEMISMLHRAWE...HDRG.AADFIQFKVEAVRHEGITCCPLLP.......LYQIDTET.....KEEGRAAAKKELL.RS............GVSETAI.GKGFAILESLI....DSMRGAAVVDAETGERLD....G.LGMRGVRCSCMDCEDTCAYEAQMGAKGL...GGEHPREALILASKVAAAPGTVAELCWSDDPFYVTGYVGSPKFGYGRITVMKEKGDPIGGRVFFV.KHG..TD...MDRYVEYMQHQTVLV R5BCC4_9FIRM/3-256 YSIRMRSAKG.......GAHENGGHHISGAXGGHHISGAERIL...S.KEELAQTASELVTRALT...HSKG.CADFIRITIDAIEDDDIVYKPALD.......VAITKADS.....VAEGLEAAYRLLE.TS............GINREAI.QKALFTLRSQP....ENMRGALICNAETGERMD....D.LGLRGVRVSRMAFADPADAIPHFEKQGH...TGVHFEEALVLASKVLGYPDILGEFCVSDDPDYAVGYVSYGHT.YHRLTPVKELGDQRGGRIFFV.KPD..TD...LDSLRHYLEETTVLV F5YMQ2_TREPZ/3-247 YSVRMRAAAG.......GSHE.........SGGAHISGAERLL...E.EDRIEKTAAEMIRRALS...HTKG.KADFIRLTIEGIDDHEITRIPGLP.......IETWEAAN.....YEEGRKHAGEFLV.NA............GVKAQAV.DRAFTALTALH....SNMRGAMLLDAVTGERLD....P.GGNRGVRVSRMDLENEATFGAWLSRQGL...DNSHTREALVLASKVLSAPETLAELCWSDDPEYVTGYVAIKGL.YHRITKLKALNDPRGGRVFFI.HPG..SD...IDALKLYLETRAVLV BIOW_BACPE/8-253 FSVRMRAAQG.......GSHE.........QGGKHISGGEKIV...P.YHDLSSCMAELAEKGLN...HSRG.KPDFMNIQFEQI.EEAVKYVSPLP.......VGTHVVSS.....VADGQATARSLLT.EA............GIKPQVI.EEAYYVLSEL.....TELRGALFIDAATGQRLD....D.PIKNGVRVTRMDWPLDDFSCWLNEHQLS...PNIRMKEALALATKVTQHPATIAELCWSDDPDYITGYVASQKFGYQRISQLKELGEEKGCRIFFV.DQTKMKN...LDAYINYLTTQPVLI BIOW_BACSU/8-251 YSVRMRASMN.......GSHE.........DGGKHISGGERLI...P.FHEMKHTVNALLEKGLS...HSRG.KPDFMQIQFEEV.HESIKTIQPLP.......VHTNEVSC.....PEEGQKLARLLLE.KE............GVSRDVI.EKAYEQIPEW.....SDVRGAVLFDIHTGKRMD....Q.TKEKGVRVSRMDWPDANFEKWALHSHVP...AHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKEYGTEEGCRVFFI.DGS..ND...VNTYIHDLEKQPILI #=GR BIOW_BACSU/8-251 SS EEEEEEEEES.......S-HH.........HC-EEEEEEEEEE...E.GGGHHHHHHHHHHHHHT...BTTB.--SEEEEEEEE-.-S--EEE----.......EEEE--SS.....HHHHHHHHHHHHH.HH............T--HHHH.HHHHHHGGGG.....TT-SSBEEEETTTTEE--....-.-TTS-B---SEE--HHHHHHHHHHHT--...--HHHHHHHHHHHHHHHSTTEEEEEEE-S-TT---EEEEETTTEEEEES-SS-TT----EEEEEE.--S..S-...HHHHHHHHHH--EEE BIOW_BACLD/7-250 YSVRMRASEN.......GPHE.........EGGKHISGGERLV...P.FIGLNDAVSDLLEKGMS...HSRG.RPDFMQIQFDLV.NEPIKLVQPLR.......IETNETVS.....AEEGQALARELIS.RA............GVPESAV.EKAFQGIAEY.....WGVRGAVLFDIHSGRRID....G.RKEKGVRVSRLDWPEADFQRWAALCGVP...PNPRLKEALAIASKVCEHPAVIAELCWSDDPDYITGYVAAKKLGYQRMTKMKEHGDESGCRIFFV.DGS..AD...VKSCIDDLEKQPVFI BIOW_META3/3-235 FSIKMRASKG......................DKHISGAETIVM..E.KENIENITAGYIKRALE...HELG.APDFINIKIDKINKKDIIYIDALP.......IKTINCKN.....KEDARRVAKNLLK.NE............GISDKLI.EKSFKIIDD......GGMRGAPILNLN.GERLE....P.DKERGVRVKNISTTEELKEKILKNNI.....GTDRTVDAIAIASKVINL.GVIAELCTSDNNSYTTGYVATKN.GYFRITNLKQENE.NGGRVFFV.KND..TN...IEDLIYKLENKPYII BIOW_METMP/2-243 FSLKMRASSN......................GNHVSGAERLV...K.EEQIEEISSELIKRAMN...HENG.VPDFINLKVEKV.TENINYIEHLK.......IKTINSNS.....KETSREFAINILK.KELENYFLKNGKDTKKIDELI.DSAFKIIDA......GNMRGAAILDLD.GNRLE....K.SSDRGIRVRNIDTAEELSKKILKDGS.....LTERTVDAIAIATKVVNC.DIIAELCTSDNFSYTTGYVATKD.GYFRILNLKDSGQ.VGGRVFFA.ESS...D...IDELYDKLENMPVIV D7DUJ0_METV3/10-269 YSLKMRASNE......................KKHISGAERLLRAEK.AEGIEKVASELIHRALT...HENG.IPDFINLKVEKV.CQKIKKIPHIPIVYNKDNIGTINNKNYEMTCKDNSRRYAHDLLK.NKFKEFDIND....VLSEFLI.KLGFEIIDE......GGMRGAAIISLD.GSRLDIAFNE.EVEKGVRVKNIDTDDRLKDKINKNEL.....YTDRTVDAIAIASKVIDL.GIVAELCTSDNPSYTTGYVATED.GYFRVKNLKDSGE.TGGRVFYV.YNLNEQL...LKELIDNLENKPYLI BIOW_METJA/6-236 YSIKMRASKN......................GKHISGAERIV...N.KDEIEETVKELVRRALT...HENG.TPDFINIKIEEI.KEEITYINHLP.......IKTIHCKD.....KEEARETAKKILR.NE............GIPDSVI.DYAYEIIDK......GGMRGAAILNLK.GERLE....P.DKERGVRVKNIDTTKELKEKILKENL.....GTERTVDAIAIASKVIHL.GVIAELCTSDNKSYTTGYVATKK.GYFRITNLKKEGE.SGGRVFFV.KDD..VD...IEDLINKLENKPFII BIOW_PERMH/3-241 YSIKLRASRD......................GKHLSGGERIV...L.KDKIEEAVNQLYRKAEP.......KDPDEINIKIESIKEKPLVIKSSLK.......IENIICED.....YKSSNQIALEILKRST............GIPVERL.KELIDLVHTGSAPDGSNMRGAMIVN.QKGERIE....L.DHFRGIRTTTVDFLDRDKILKKLVKKG....YTERTVDALCLTTKNMLYPDMIAEYCISDEPDYITGYVSTKDF.YYRITPLKSEGNPKGGRIYFV.RNS..ID...LQDFYRFLQEKPVLI B4U8N9_HYDS0/5-238 ISIRMRASFK......................NVHISGAERIC...K.KEKVSQIINEFLERPKF.........YDFISIKTEEVKDVEFIKTPS.........IRSFDFKS.....VEEARAFAKTLLG.NA............SIKKNIA.ESILELISKG.AAFGKNMRGAMIIDIDTGIRLE....E.NKEKGIRTIKVDWEDRDLAKQKLLSSGYK..ITDRALDALALVSKNIRC.GILAEVCWSDDADYTTGYVVVNKT.YYRINPMKHFGDLFGGRAYFI.KAE...N...LKDVINCLRNKAFLV BIOW_AQUAE/4-238 FSVRMRAQKN......................GKHVSGAERIV...K.KEELETAVKELLNRPKE.........FDFMNVKVEKVKDFEV.VKFNLK.......ISTYSFKS.....PEEAREFAVKKLT.QE............GIKEEVA.KKAVEILSKGANPKGGNMRGAVLMDIETGERLE....E.DKERGVRTIHFDWKDRKKVTEKLLKEG....YTLRTVDALALTFKNLFC.GVVAELCWSDDPDYVTGYVSGKEIGYVRITPLKEKGDPLGGRVYFV.SRK...E...LSEIIECLTQKVVLI #=GR BIOW_AQUAE/4-238 SS EEEEEEEEET......................TEEEEEEEEEE...E.GGGHHHHHHHHHHSSSS.........-SEEEEEEEE-SSEEE.EE----.......EEEEE-SS.....HHHHHHHHHHHHH.TT............T--HHHH.HHHHHHHHH-SSTTSS--SSBEEEETTT-SB--....S.STTT-B---SEEETTHHHHHHHHHHTT....--HHHHHHHHHHHHHHHT.T--EEEEE-SSTT---EEEEETTTEEEEEETSS-TT----EEEEEE.-GG...G...HHHHHHHHHH-EEEE BIOW_THEAH/3-240 .SIRMRAEFQ......................GEHVSGAERIV...P.YHEVEKTVLELLKRPRV.........YDKVVITVERLKDVEI.VPKALP.......ILSYDFKS.....VEEARAFAVSKLV.EA............GVPKPVA.ELAIKLLHEGPNPKGGNMRGAVLMDVETGERLE....P.DRERGIRTTRMDWKDRKYIKEVLKKRGIKREYLERLIDALAVATKNVYC.GVLAELCWSDDPEYTTGYVAGPHIGYVRIKPMKEEGVPIGGRVYFI.RKE...N...LEKIIQCLQEKPILI BIOW_HYDTT/3-240 .SVRMRAELD......................GMHVSGAERVI...P.HYELEKVVMELLKRPKR.........YDKIVITIERVENLET.IPKSLP.......IKSHDFAD.....VEQAHEFVIKKLK.EI............GIEESIT.QKALKLLTEGPNPKGGNMRGAVLMDPVSGERLE....P.DQERGIRTTRIDWRNRTAIKEALRERGIKKFYLERLIDALAIATKNIHC.GVIAEICWSDDPEYTTGYIASKEFGYIRIKPMKEEHTPTGGRVYFV.KRE...S...LQELIECLERKVMLI BIOW_STAEQ/2-222 YSIKMRASHE......................DIHISGAETMC...E.FEDLENYLKKYFNKAFN...HENG.NIDFLNLKIEKV.KAPIQTLVALP.......V............VENLNDTLTQLAK.QT............GVSEYAL.NKGLEFIKND.....ITYTGAIILSAQTGQRLD....S.TEQRGIRVTQLAFKTCKCNGE..........ISERVKDARALATCINAFEGVKAELCVSDDLHYTTGYFASPKLGYRRIFNIKEKGTRHGGRIIFV.DEG..IN...LNAYVSFLETVP... BIOW_STAA8/2-222 YSIKMRSSNQ......................DVHISGAETIC...E.FDKIEQTVQRFYNKGFF...HENG.QPDFLNIKIQKI.MEPIQQIKALQ.......I............IEDDKANLQHLTQ.EC............GVTEQAL.NQGMTYIKNE.....TVYTGAIILSAISGKRLD....S.FGQRGIRATHFSFEDINNKGD..........LNERVTDALAIASCINAHPYVKGELCVSDDLTYTTGYFAAAKIGYHRLFDIKPVNTRYGGRIIFV.DDC..ID...LNHYISFLESTP... F0S3F4_DESTD/5-245 YSVKMRSSKE......................GLHISGAERIV...L.EEELKTVAIQLIERALN...HSRG.KADFVNLKIEELKKNPV.YSPLLP.........VFEVTD.....YKSVKELLKKLFS.LS............KVPLELG.IEVYKKLLTGPAPNGQIMRGAMIVAVPSGKRLE....P.NQYRGVRASYLDVDKETVSILKEKLEDR...YTENFKEALVLSTKILHFNNVLGELCVSDDPDYTIGYLSLKGKGYFRIKNIKPQGLPKGGRAIFV.EEK..ID...VEKFINYLEKEPFIA C9LVH2_SELS3/4-238 YSLKMRAEKN...................AGKREHVSGAEKIL...S.EEELPEHLAALLSRALH...HAKG.KADFVNFKVEAIAPEAVEHLPALP.......VSTVEVET.....PAEGRRVIIDALE.NL............GLKNG...EAILAKFSET.....YGMRGAMLLDADTLERLE....P.DAERGLRATYMDAERAAKGASD.........CKNHFAEAVVLATKVVHAPHIVAEICVSDDPDYVTGYVAAQSFGYRRITKLKEAGSPDGGRIFLY.RGSRD.G...VADTIRYLEKQCVLV D4M1V7_9FIRM/7-243 YSIKMRASKK..................ENGTDVHISGAEKIV...E.APDVDIFANALIERGMH...HSKG.EADALNLKINKVCKENIIYLDALS.......VETIEVET.....WEKGQEEIKKYLK.ET............GIDNP...QDVMQFLDET.....YAMRGAMLLDVDRLIRLE....P.DKKRGIRATNMDQERMKGDRIGN........EKNHYEEAIVLATKVANCPGIIGEICISDDPEYVTGYVSSKEIGYRRITKMKRMGSEKGGRIFLF.RGTDA.E...EQKAIDFLQNQHVIV BIOW_FIBSS/4-254 YSLKMRASQH..............VGEGENSHEQHISGAERIV...G.RDSVEAVCAAMVRRAMN...HSKG.DPDFINVKIEKVHESDIQVLKSLP.......VTRVDVET.....WQEGLEKAFGLIT.PLMALRQAQGPCDGAKKFK...EKLQDLLRET.....FPMRGAMLYDIATGNRLE....P.DKDRGVRATYMDALHSSEVDG..........CKNHFNEAIVLATKVANAPGMVAEFCVSDDPNYVTGYVASKELGYVRIMKMKEMGDENGGRIFLF.DSRKA.S...AEECIEYLQKKKVLV BIOW_DESDA/3-230 YSIKMRAESG......................SRHISGAERIV...E.RRDMAQAMDALTRRGME...HPNG.PAEAVTVTVRPI.TRPLMHIQALP.......VHEPHVRD.....QHEARQVLTEELR...............GMALDP..SPVLDLLYSLR....KPMRGAVLLDVTGMKRLE....P.DPQRGVRATCMDYTGNRCE............GKNHFREALCLASKVAHCPQIIGELCISDDPDYTTGYFASQVRGYVRIHHIKQAGQQLGGRIFLF.RGQQA.E...IGQCVDYLENQPVMV D9QAS8_CORP2/4-242 YSVRMRASLQ......................GQHISGAETLV...SCPTDVPRLTAQFVERAMN...HAKG.VPDAITTKIESIPESDIQRVPRLL.......TREYQARD.....CHDAHGFVQQQLT.TV.............CSAEVA.QKAVDLLLTI.....RNMRGAILLDAHSARRLE....P.DHNRGIRASNFGDASSISAKPDNKEIGI...SKNHYHEALILSSKVMSAPGIIAEICISDDPDYTTGYVSLNGV.YTRVHTMKRLGSPLGGRVFIL.DSEKA.S...VATAINHIENTPVLI BIOW_CORDI/10-243 VSIKMHASSN......................GAHISGAETLV...D.ESRAYEFLSSFYQRANT...HSKG.KPEITTLTIRRIKDADIITIPALE.......VKCLPALH.....PSEAHRQVIEQLS.NV.............VSPTIA.QMALHTVLNA.....RNMRGAILLCAHTGQRLD....PYDPQRGVRASTFGVTPQESAGP.....TL...NKSHFNEALVLASKVMSAPGIVAEICISDDPAYTTGYVTTENT.YIRIPHMKDPYSPIGGRVFLL.DTRVS.T...PEDTISYLEQKPVLI W5Y0Z9_9CORY/9-240 YSVKMRASRG......................GEHISGAERIC...T.SEHVGPIAASLNERALG...HPKG.TPDEIHLTVRGVDPVSIGYVPALE.......VEEVPCQS.....PEQARDFISTRLK.EL............GVAAPVA.RRVDELMHTV.....SGLRGAMLVDARTGERIE....P.DRERGVRVTNLDARSQVTGP...........TKNHHHEALVLASKVCHHPKILAEVCISDDPDYTTGYLAARGT.YYRIPKIKRPGEDVGTRVFVC.APMTAEE...KKELISYLENRVIVV #=GC SS_cons EEEEEEEEET.......S.HH.........HCTEEEEEEEEEE...E.GGGHHHHHHHHHHCCCT...BTTB..-SEEEEEEEE-SSCEEEEE----.......EEEEE-SS.....HHHHHHHHHHHHH.CC............T--HHHH.HHHHHHHHHGSSTTSTT-SSBEEEETTTTCE--....S.STTT-B---SEEETCHHHHHHHHHHTT....--HHHHHHHHHHHHHHHTTTEEEEEEE-SSTT---EEEEETTTEEEEECTSS-TT----EEEEEE.-GC..SG...HHHHHHHHHH-EEEE #=GC seq_cons YSl+MRASps......................GcHISGAERIV...p.pcclcpslspLlcRAhs...HppG.psDFlsl+lEclpcpsI.hlssLP.......lpshcsps.....h--u+chspphLp.pt............Glspphh.ccuhchlpph.....psMRGAhllDspoGcRL-....s.ctpRGVRsophDhpcpsptchthttps....ssp+hpEALsLASKVhptPullAELChSDDP-YTTGYVuscchGYhRIsslKctGs.tGGRlFFl.css...-...lpchIsaLEppsVLl //