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12  structures 2627  species 0  interactions 3274  sequences 6  architectures

Family: KdpA (PF03814)

Summary: Potassium-transporting ATPase A subunit

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Potassium-transporting ATPase A subunit Provide feedback

No Pfam abstract.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR004623

Kdp is a high affinity ATP-driven K+ transport system in Escherichia coli. It is composed of three membrane-bound subunits, KdpA, KdpB and KdpC and one small peptide, KdpF. KdpA is the K+-transporting subunit of this complex. During assembly of the complex, KdpA and KdpC bind to each other. This interaction is thought to stabilise the complex. Data indicates that KdpC might connect the KdpA, the K+-transporting subunit, to KdpB, the ATP-hydrolysing (energy providing) subunit [ PUBMED:9858692 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Ion_channel (CL0030), which has the following description:

This superfamily contains a diverse range of ion channels that share a pair of transmembrane helices in common. This clan is classified as the VIC (Voltage-gated Ion Channel) superfamily in TCDB.

The clan contains the following 8 members:

Ion_trans Ion_trans_2 IRK KdpA Lig_chan PKD_channel Polycystin_dom TrkH

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(204)
Full
(3274)
Representative proteomes UniProt
(18320)
RP15
(299)
RP35
(1441)
RP55
(3456)
RP75
(6927)
Jalview View  View  View  View  View  View  View 
HTML View  View           
PP/heatmap 1 View           

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(204)
Full
(3274)
Representative proteomes UniProt
(18320)
RP15
(299)
RP35
(1441)
RP55
(3456)
RP75
(6927)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(204)
Full
(3274)
Representative proteomes UniProt
(18320)
RP15
(299)
RP35
(1441)
RP55
(3456)
RP75
(6927)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: TIGRFAMs
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: TIGRFAMs, Griffiths-Jones SR
Number in seed: 204
Number in full: 3274
Average length of the domain: 532 aa
Average identity of full alignment: 48 %
Average coverage of the sequence by the domain: 97.46 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.6 22.6
Trusted cut-off 22.6 22.6
Noise cut-off 22.4 22.2
Model length: 546
Family (HMM) version: 18
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the KdpA domain has been found. There are 12 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0H3GLH1 View 3D Structure Click here
A0R395 View 3D Structure Click here
A1TED2 View 3D Structure Click here
A1TJ24 View 3D Structure Click here
A1UKX6 View 3D Structure Click here
A1VTC2 View 3D Structure Click here
A2SIS3 View 3D Structure Click here
A4G5J9 View 3D Structure Click here
A5GAG2 View 3D Structure Click here
A6H086 View 3D Structure Click here
A6L5D2 View 3D Structure Click here
A6LIU6 View 3D Structure Click here
A6T6D9 View 3D Structure Click here
A6W6R5 View 3D Structure Click here
A6X5H8 View 3D Structure Click here
A7I5F0 View 3D Structure Click here
A8AJB7 View 3D Structure Click here
A9AXU9 View 3D Structure Click here
A9C190 View 3D Structure Click here
A9F773 View 3D Structure Click here
A9MK88 View 3D Structure Click here
B0JJ94 View 3D Structure Click here
B0RCI3 View 3D Structure Click here
B1M7D7 View 3D Structure Click here
B1Z9Y2 View 3D Structure Click here
B2IIP5 View 3D Structure Click here
B2UH25 View 3D Structure Click here
B2VJK4 View 3D Structure Click here
B4U8E3 View 3D Structure Click here
B5EH80 View 3D Structure Click here
B6IQY9 View 3D Structure Click here
B7JY03 View 3D Structure Click here
B8GVF8 View 3D Structure Click here
B8I9I5 View 3D Structure Click here
B8J1E9 View 3D Structure Click here
B9JKQ7 View 3D Structure Click here
B9K2I3 View 3D Structure Click here
C1D7X0 View 3D Structure Click here
C1FA47 View 3D Structure Click here
C3K4Y3 View 3D Structure Click here