Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 323  species 0  interactions 4152  sequences 25  architectures

Family: OAR (PF03826)

Summary: OAR motif

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

OAR motif Provide feedback

The entry represents the OAR motif.

This tab holds annotation information from the InterPro database.

InterPro entry IPR003654

This 14 amino acid motif has been identified within the C-terminal region of several paired-like homeodomain (HD) containing proteins [ PUBMED:8944018 , PUBMED:9466998 ]. It was named OAR domain after the initials of otp, aristaless, and rax [ PUBMED:9096350 ]. Although it has been proposed that this domain could be important for transactivation and be involved in protein-protein interactions or DNA binding [ PUBMED:9096350 , PUBMED:9140395 ], its function is not yet known. Some proteins known to contain a OAR domain include human RIEG, defects in which are the cause of Rieger syndrome [ PUBMED:8944018 ]; human OG12X and Mus musculus (Mouse) Og12x, whose function is not yet known [ PUBMED:9466998 ]; vertebrate Rax, which plays a role in the proliferation and/or differentiation of retinal cells [ PUBMED:9096350 ]; Drosophila DRX, which appears to be important in brain development [ PUBMED:9482887 ]; and human SHOX, encoded by the short stature homeobox-containing gene.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

Loading domain graphics...

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(43)
Full
(4152)
Representative proteomes UniProt
(6886)
RP15
(511)
RP35
(1498)
RP55
(3736)
RP75
(4921)
Jalview View  View  View  View  View  View  View 
HTML View  View           
PP/heatmap 1 View           

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(43)
Full
(4152)
Representative proteomes UniProt
(6886)
RP15
(511)
RP35
(1498)
RP55
(3736)
RP75
(4921)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(43)
Full
(4152)
Representative proteomes UniProt
(6886)
RP15
(511)
RP35
(1498)
RP55
(3736)
RP75
(4921)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: PROSITE
Previous IDs: none
Type: Motif
Sequence Ontology: SO:0001067
Author: Griffiths-Jones SR
Number in seed: 43
Number in full: 4152
Average length of the domain: 18.80 aa
Average identity of full alignment: 55 %
Average coverage of the sequence by the domain: 5.81 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.1 20.1
Trusted cut-off 20.1 20.2
Noise cut-off 20.0 20.0
Model length: 19
Family (HMM) version: 19
Download: download the raw HMM for this family

Species distribution

Sunburst controls

Hide

Weight segments by...


Change the size of the sunburst

Small
Large

Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

Align selected sequences to HMM

Generate a FASTA-format file

Clear selection

This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Loading sunburst data...

Tree controls

Hide

The tree shows the occurrence of this domain across different species. More...

Loading...

Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.

AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JXV9 View 3D Structure Click here
A0A0G2KXF6 View 3D Structure Click here
A0A0R4IJ70 View 3D Structure Click here
A0AVV3 View 3D Structure Click here
A6NNA5 View 3D Structure Click here
A6YP92 View 3D Structure Click here
A8DYR8 View 3D Structure Click here
B0S5T0 View 3D Structure Click here
B2LT56 View 3D Structure Click here
B3DGA5 View 3D Structure Click here
B3DHJ6 View 3D Structure Click here
D3ZEM1 View 3D Structure Click here
D3ZMA3 View 3D Structure Click here
E7FGP3 View 3D Structure Click here
G3V7E0 View 3D Structure Click here
G3V7K0 View 3D Structure Click here
I3ITE6 View 3D Structure Click here
O09113 View 3D Structure Click here
O15266 View 3D Structure Click here
O18400 View 3D Structure Click here
O35085 View 3D Structure Click here
O35137 View 3D Structure Click here
O35160 View 3D Structure Click here
O35602 View 3D Structure Click here
O35750 View 3D Structure Click here
O42115 View 3D Structure Click here
O42356 View 3D Structure Click here
O42357 View 3D Structure Click here
O42358 View 3D Structure Click here
O42477 View 3D Structure Click here
O60902 View 3D Structure Click here
O75364 View 3D Structure Click here
P54821 View 3D Structure Click here
P58304 View 3D Structure Click here
P63013 View 3D Structure Click here
P63014 View 3D Structure Click here
P70314 View 3D Structure Click here
P70390 View 3D Structure Click here
P78337 View 3D Structure Click here
P81062 View 3D Structure Click here
P97474 View 3D Structure Click here
Q06348 View 3D Structure Click here
Q06453 View 3D Structure Click here
Q15699 View 3D Structure Click here
Q1LVQ7 View 3D Structure Click here
Q566X8 View 3D Structure Click here
Q5XKR4 View 3D Structure Click here
Q61412 View 3D Structure Click here
Q62798 View 3D Structure Click here
Q63087 View 3D Structure Click here
Q6DGH9 View 3D Structure Click here
Q6P295 View 3D Structure Click here
Q6QU75 View 3D Structure Click here
Q7SZN8 View 3D Structure Click here
Q7T373 View 3D Structure Click here
Q8BYH0 View 3D Structure Click here
Q8C8B0 View 3D Structure Click here
Q8JI10 View 3D Structure Click here
Q8NFW5 View 3D Structure Click here
Q91ZK4 View 3D Structure Click here
Q96QS3 View 3D Structure Click here
Q99697 View 3D Structure Click here
Q99811 View 3D Structure Click here
Q99NA7 View 3D Structure Click here
Q9H161 View 3D Structure Click here
Q9JLT7 View 3D Structure Click here
Q9R0W1 View 3D Structure Click here
Q9W2Q1 View 3D Structure Click here
Q9W5Z2 View 3D Structure Click here
Q9Y2V3 View 3D Structure Click here
X2JDS9 View 3D Structure Click here

trRosetta Structure

The structural model below was generated by the Baker group with the trRosetta software using the Pfam UniProt multiple sequence alignment.

The InterPro website shows the contact map for the Pfam SEED alignment. Hovering or clicking on a contact position will highlight its connection to other residues in the alignment, as well as on the 3D structure.

Improved protein structure prediction using predicted inter-residue orientations. Jianyi Yang, Ivan Anishchenko, Hahnbeom Park, Zhenling Peng, Sergey Ovchinnikov, David Baker Proceedings of the National Academy of Sciences Jan 2020, 117 (3) 1496-1503; DOI: 10.1073/pnas.1914677117;