Summary: RasGAP C-terminus
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RasGAP C-terminus Provide feedback
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External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR000593
Ras GTPase-activating protein (rasGAP) is a major contributor to the down-regulation of ras by facilitating GTP hydrolysis of activated ras. In addition, GAP participates in the down-stream effector system of the ras signalling pathway. Abnormal signal transduction involving activated ras genes plays a major role in the development of a variety of tumours. Depending on the precise genetic alteration, its location within the gene and the effects it exerts on protein function, rasGAP can theoretically function as either an oncogene or as a tumour suppressor gene [PUBMED:8738474].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||intracellular (GO:0005622)|
|Molecular function||Ras GTPase activator activity (GO:0005099)|
|Biological process||small GTPase mediated signal transduction (GO:0007264)|
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Number in seed:||38|
|Number in full:||469|
|Average length of the domain:||133.50 aa|
|Average identity of full alignment:||33 %|
|Average coverage of the sequence by the domain:||10.26 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||10|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the RasGAP_C domain has been found. There are 6 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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