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YIF1 (Yip1 interacting factor) is an integral membrane protein that is required for membrane fusion of ER derived vesicles . It also plays a role in the biogenesis of ER derived COPII transport vesicles .
Barrowman J, Wang W, Zhang Y, Ferro-Novick S; , J Biol Chem. 2003;278:19878-19884.: The Yip1p.Yif1p complex is required for the fusion competence of endoplasmic reticulum-derived vesicles. PUBMED:12657649 EPMC:12657649
Heidtman M, Chen CZ, Collins RN, Barlowe C; , Mol Biol Cell. 2005;16:1673-1683.: Yos1p is a novel subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex. PUBMED:15659647 EPMC:15659647
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR005578This family includes a number of eukaryotic proteins. It is an integral membrane protein, conserved in at least 1 copy in all sequenced eukaryotes. The gene name in Schizosaccharomyces pombe (Fission yeast) is hrf1+ for Heavy metal Resistance Factor 1.
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
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Yip1 and YIF1 are members of an integral membrane complex which bind to Ras-like GTPases and are required for membrane fusion of ER derived vesicles with the Golgi .
The clan contains the following 6 members:DUF1048 DUF1129 DUF1282 DUF1700 YIF1 Yip1
We make a range of alignments for each Pfam-A family:
- the curated alignment from which the HMM for the family is built
- the alignment generated by searching the sequence database using the HMM
- Representative Proteomes (RPs) at 15%, 35%, 55% and 75% co-membership thresholds
- alignment generated by searching the NCBI sequence database using the family HMM
- alignment generated by searching the metagenomics sequence database using the family HMM
You can see the alignments as HTML or in three different sequence viewers:
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Curation and family details
|Seed source:||Wood V|
|Author:||Wood V, Bateman A|
|Number in seed:||123|
|Number in full:||864|
|Average length of the domain:||223.50 aa|
|Average identity of full alignment:||32 %|
|Average coverage of the sequence by the domain:||70.46 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||11|
|Download:||download the raw HMM for this family|
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