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0  structures 1649  species 0  interactions 7001  sequences 142  architectures

Family: Glyco_transf_22 (PF03901)

Summary: Alg9-like mannosyltransferase family

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Alg9-like mannosyltransferase family Provide feedback

Members of this family are mannosyltransferase enzymes [1-2]. At least some members are localised in endoplasmic reticulum and involved in GPI anchor biosynthesis [3-4].

Literature references

  1. Baysal BE, Willett-Brozick JE, Badner JA, Corona W, Ferrell RE, Nimgaonkar VL, Detera-Wadleigh SD; , Neurogenetics 2002;4:43-53.: A mannosyltransferase gene at 11q23 is disrupted by a translocation breakpoint that co-segregates with bipolar affective disorder in a small family. PUBMED:12030331 EPMC:12030331

  2. Oriol R, Martinez-Duncker I, Chantret I, Mollicone R, Codogno P; , Mol Biol Evol 2002;19:1451-1463.: Common origin and evolution of glycosyltransferases using Dol-P-monosaccharides as donor substrate. PUBMED:12200473 EPMC:12200473

  3. Nagamune K, Nozaki T, Maeda Y, Ohishi K, Fukuma T, Hara T, Schwarz RT, Sutterlin C, Brun R, Riezman H, Kinoshita T; , Proc Natl Acad Sci U S A 2000;97:10336-10341.: Critical roles of glycosylphosphatidylinositol for Trypanosoma brucei. PUBMED:10954751 EPMC:10954751

  4. Sutterlin C, Escribano MV, Gerold P, Maeda Y, Mazon MJ, Kinoshita T, Schwarz RT, Riezman H; , Biochem J 1998;332:153-159.: Saccharomyces cerevisiae GPI10, the functional homologue of human PIG-B, is required for glycosylphosphatidylinositol-anchor synthesis. PUBMED:9576863 EPMC:9576863


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR005599

Members of this family are glycosylphosphatidylinositol mannosyltransferase enzymes [intenz:2.4.1.-] [ PUBMED:9576863 , PUBMED:10954751 ]. At least some members are localised in endoplasmic reticulum and involved in glycosyl phosphatidyl inositol (GPI) anchor biosynthesis [ PUBMED:12200473 , PUBMED:12030331 ]. In Arabidopsis, mannosyltransferase APTG1 (Abnormal Pollen Tube Guidance1) is required for pollen tube micropylar guidance and embryo development [ PUBMED:24963069 ]. In budding yeast, Smp3 (YOR149C) has been implemented in plasmid stability [ PUBMED:2005867 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan GT-C (CL0111), which has the following description:

This is the GT-C clan that contains diverse glycosyltransferases that possess 8-13 predicted transmembrane segments [1].

The clan contains the following 24 members:

AftA_N ALG3 Alg6_Alg8 Arabinose_trans DIE2_ALG10 Dpy19 DUF2079 DUF2142 DUF2298 DUF2723 DUF3367 EpsG Glucan_synthase Glucos_trans_II Glyco_transf_22 GT87 Mannosyl_trans Mannosyl_trans2 PIG-U PMT PMT_2 PTPS_related STT3 YfhO

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(16)
Full
(7001)
Representative proteomes UniProt
(12284)
RP15
(1358)
RP35
(3167)
RP55
(5382)
RP75
(7328)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(16)
Full
(7001)
Representative proteomes UniProt
(12284)
RP15
(1358)
RP35
(3167)
RP55
(5382)
RP75
(7328)
Alignment:
Format:
Order:
Sequence:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(16)
Full
(7001)
Representative proteomes UniProt
(12284)
RP15
(1358)
RP35
(3167)
RP55
(5382)
RP75
(7328)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: DOMO:DM04662 & Pfam-B_7750 (Release 8.0)
Previous IDs: PMP;
Type: Family
Sequence Ontology: SO:0100021
Author: Finn RD , Bateman A
Number in seed: 16
Number in full: 7001
Average length of the domain: 360.9 aa
Average identity of full alignment: 19 %
Average coverage of the sequence by the domain: 68.38 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.8 23.8
Trusted cut-off 23.8 23.8
Noise cut-off 23.6 23.7
Model length: 417
Family (HMM) version: 20
Download: download the raw HMM for this family

Species distribution

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Selections

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A044QRM5 View 3D Structure Click here
A0A044RBX9 View 3D Structure Click here
A0A077YX33 View 3D Structure Click here
A0A077YZH7 View 3D Structure Click here
A0A077Z8G7 View 3D Structure Click here
A0A0D2DEM0 View 3D Structure Click here
A0A0D2GPJ3 View 3D Structure Click here
A0A0D2GSK3 View 3D Structure Click here
A0A0D2GY45 View 3D Structure Click here
A0A0K0DXE0 View 3D Structure Click here
A0A0K0EAE5 View 3D Structure Click here
A0A0K0EE43 View 3D Structure Click here
A0A0N4U0M5 View 3D Structure Click here
A0A0N4UAZ8 View 3D Structure Click here
A0A0N4UPD1 View 3D Structure Click here
A0A0R0GSP5 View 3D Structure Click here
A0A0R0J2W1 View 3D Structure Click here
A0A0R0KMM9 View 3D Structure Click here
A0A0R4IE52 View 3D Structure Click here
A0A158N873 View 3D Structure Click here
A0A175VW84 View 3D Structure Click here
A0A175VYA5 View 3D Structure Click here
A0A175W637 View 3D Structure Click here
A0A175WDR7 View 3D Structure Click here
A0A1C1CDU5 View 3D Structure Click here
A0A1C1CER1 View 3D Structure Click here
A0A1C1CLC5 View 3D Structure Click here
A0A1C1CPY0 View 3D Structure Click here
A0A1D6E4B0 View 3D Structure Click here
A0A1D6GYC2 View 3D Structure Click here
A0A1D6GYE5 View 3D Structure Click here
A0A1D6KX48 View 3D Structure Click here
A0A1D6MG89 View 3D Structure Click here
A0A1D8PE04 View 3D Structure Click here
A0A3P7DUE6 View 3D Structure Click here
A0A3P7DV51 View 3D Structure Click here
A0A3P7E449 View 3D Structure Click here
A0A5K4F0L1 View 3D Structure Click here
A0A5K4F3P3 View 3D Structure Click here
A0A5K4F436 View 3D Structure Click here