Summary: Gal4-like dimerisation domain
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Gal4-like dimerisation domain Provide feedback
No Pfam abstract.
Hidalgo P, Ansari AZ, Schmidt P, Hare B, Simkovich N, Farrell S, Shin EJ, Ptashne M, Wagner G; , Genes Dev 2001;15:1007-1020.: Recruitment of the transcriptional machinery through GAL11P: structure and interactions of the GAL4 dimerization domain. PUBMED:11316794 EPMC:11316794
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR005600
The DNA binding domain (residues 1 to 147) of the yeast transcriptional activator GAL4 exists in solution in dimeric form, with the region responsible for dimerisation somewhere between residues 74 and 147. Experimental studies confirmed that the 'hydrophobic region' of the protein (residues 54-97, which contains a larger proportion of alpha-helix), is essential for dimerisation [PUBMED:8765712].
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Number in seed:||4|
|Number in full:||57|
|Average length of the domain:||49.00 aa|
|Average identity of full alignment:||39 %|
|Average coverage of the sequence by the domain:||7.09 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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There is 1 interaction for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Gal4_dimer domain has been found. There are 6 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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