# STOCKHOLM 1.0 #=GF ID Tubulin_C #=GF AC PF03953.19 #=GF DE Tubulin C-terminal domain #=GF PI tubulin_C; #=GF AU Bateman A;0000-0002-6982-4660 #=GF AU Sonnhammer ELL;0000-0002-9015-5588 #=GF AU Griffiths-Jones SR;0000-0001-6043-807X #=GF SE Prosite #=GF GA 26.60 26.60; #=GF TC 26.60 26.70; #=GF NC 26.30 26.50; #=GF BM hmmbuild HMM.ann SEED.ann #=GF SM hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq #=GF TP Domain #=GF CL CL0442 #=GF RN [1] #=GF RM 9428769 #=GF RT Structure of the alphabeta tubulin dimer by electron #=GF RT crystallography. #=GF RA Nogales E, Wolf SG, Downing KH; #=GF RL Nature 1998;391:199-203. #=GF RN [2] #=GF RM 9628483 #=GF RT Tubulin and FtsZ form a distinct family of GTPases. #=GF RA Nogales E, Downing KH, Amos LA, Lowe J; #=GF RL Nat Struct Biol 1998;5:451-458. #=GF RN [3] #=GF RM 9428770 #=GF RT Crystal structure of the bacterial cell-division protein FtsZ #=GF RT [see comments] #=GF RA Lowe J, Amos LA; #=GF RL Nature 1998;391:203-206. #=GF DR INTERPRO; IPR018316; #=GF DR PROSITE; PDOC00199; #=GF DR PROSITE; PDOC00200; #=GF DR PROSITE; PDOC00873; #=GF DR SCOP; 1tub; fa; #=GF DR HOMSTRAD; tubulin; #=GF DR SO; 0000417; polypeptide_domain; #=GF CC This family includes the tubulin alpha, beta and gamma chains. #=GF CC Members of this family are involved in polymer formation. #=GF CC Tubulins are GTPases. FtsZ can polymerise into tubes, sheets, #=GF CC and rings in vitro and is ubiquitous in eubacteria and archaea. #=GF CC Tubulin is the major component of microtubules. (The FtsZ #=GF CC GTPases have been split into their won family). #=GF SQ 34 #=GS TBA_DICDI/270-402 AC P32255.1 #=GS C4LYU0_ENTHI/268-398 AC C4LYU0.1 #=GS C4LYF7_ENTHI/261-382 AC C4LYF7.1 #=GS TBG_CAEEL/264-391 AC P34475.1 #=GS TBG_DICDI/261-387 AC Q55AR3.1 #=GS Q8IAN7_PLAF7/265-389 AC Q8IAN7.1 #=GS Q23FR3_TETTS/263-388 AC Q23FR3.2 #=GS A8INY3_CHLRE/264-398 AC A8INY3.1 #=GS TBG_EMENI/263-392 AC P18695.3 #=GS TBG_SCHPO/264-393 AC P25295.1 #=GS TBG2_DROME/264-394 AC P42271.3 #=GS TBG1_HUMAN/264-393 AC P23258.2 #=GS TBG1_HUMAN/264-393 DR PDB; 3CB2 B; 264-393; #=GS TBG1_HUMAN/264-393 DR PDB; 6V5V g; 264-393; #=GS TBG1_HUMAN/264-393 DR PDB; 1Z5V A; 264-393; #=GS TBG1_HUMAN/264-393 DR PDB; 1Z5W A; 264-393; #=GS TBG1_HUMAN/264-393 DR PDB; 3CB2 A; 264-393; #=GS D6XD01_TRYB2/266-392 AC D6XD01.1 #=GS TBG_YEAST/263-392 AC P53378.1 #=GS TBG_YEAST/263-392 DR PDB; 5FLZ D; 263-392; #=GS TBG_YEAST/263-392 DR PDB; 5FM1 C; 263-392; #=GS TBG_YEAST/263-392 DR PDB; 5FLZ C; 263-392; #=GS TBG_YEAST/263-392 DR PDB; 5FM1 D; 263-392; #=GS TBE_MOUSE/294-414 AC Q9D6T1.1 #=GS Q4FKF8_TRYB2/297-426 AC Q4FKF8.1 #=GS L2G737_COLFN/261-380 AC L2G737.1 #=GS TBB_SCHPO/261-383 AC P05219.2 #=GS TBB_SCHPO/261-383 DR PDB; 5MLV N; 261-383; #=GS TBB_SCHPO/261-383 DR PDB; 6S8M B; 261-383; #=GS TBB_SCHPO/261-383 DR PDB; 5MLV C; 261-383; #=GS TBB_SCHPO/261-383 DR PDB; 5MLV F; 261-383; #=GS TBB_SCHPO/261-383 DR PDB; 5MLV L; 261-383; #=GS TBB_SCHPO/261-383 DR PDB; 5MLV I; 261-383; #=GS TBB_SCHPO/261-383 DR PDB; 5MLV R; 261-383; #=GS TBB_DICDI/266-388 AC P32256.2 #=GS TBB_ENCCU/261-382 AC Q8SS99.1 #=GS TBB_STRPU/106-227 AC P18700.1 #=GS TBBP_DROME/260-382 AC Q9VRX3.1 #=GS F6HWX4_VITVI/87-217 AC F6HWX4.1 #=GS P91873_CAEEL/269-399 AC P91873.2 #=GS V5E7D2_KALBG/262-391 AC V5E7D2.1 #=GS K1WWQ1_MARBU/263-392 AC K1WWQ1.1 #=GS TBA2_SCHPO/263-393 AC P04689.2 #=GS TBA1_YEAST/264-394 AC P09733.2 #=GS TBA1_YEAST/264-394 DR PDB; 4FFB A; 264-394; #=GS TBA1_YEAST/264-394 DR PDB; 5W3F A; 264-394; #=GS TBA1_YEAST/264-394 DR PDB; 5W3H A; 264-394; #=GS TBA1_YEAST/264-394 DR PDB; 5W3J A; 264-394; #=GS TBA1_YEAST/264-394 DR PDB; 4U3J A; 264-394; #=GS TBA4_DROME/274-404 AC P06606.1 #=GS TBA_ENCCU/259-388 AC Q8SRI6.1 #=GS S7XG08_SPRLO/260-389 AC S7XG08.1 #=GS TBA2_EMENI/265-395 AC P24634.2 #=GS O18154_CAEEL/260-388 AC O18154.1 #=GS TBAL3_HUMAN/270-400 AC A6NHL2.2 TBA_DICDI/270-402 PRLHFVLCSYAPVISRE.....KAHHETITVDNITSAVFSEKNIMA..KCQPNL........GKYMACCL.MYRGDIVPKEAQKAVQNIRSEKSRNVSFVDWSPTGFKCGINNQAPVSTKDSEMAEVKKSVCMLSNTTAISQVFSRINH C4LYU0_ENTHI/268-398 PRDHFAMMSYAPIVTPE.....KAIRQTLSVQELTSSLFDPNSLMI..QCDDIN.......KGKFMSCCM.MYRGDVSSREVNLAVSGIKKQNT..VPFVGWCPCSFKCGINSQPATAVPGSSYASTARSACMIANHTAMCQVFQKVN. C4LYF7_ENTHI/261-382 ..SHFLMTSYTPLRQVN.....Q.ISSRTSAIDVMKRLIQPQNIMA..RTRLKE........GKYISMCD.FFQGDVSYDEINEALQRFTDRRL..AEFVPWNKEAIKVVHTRVSPLVKRGN.....RMSGMLLANNTSIRYYFQDIL. TBG_CAEEL/264-391 PPMHFIQSAISPVVDPN.....ENFTRKTSVADVTRFLLKPTSMMVSTASRVRP........NDCMLSAYMFLQGQIEAHTIMTAEQNVDFAIR...RPPFYMLKPLRMMHAPLSPYVRPQY.....KVSGLLLNNSTSVAPLFESLLS TBG_DICDI/261-387 PKCHFLITGYTPLSIDR....QTESVRKTSVLDVMRRLLQPQNIMV..SAPTK........TGKYISILN.IIQGDVDPTQIHNSLQRIREKRM..ATFIDWGPASIQIALSKKSPYIKSSH.....KVSGLMLANHTSVNHLFSHIIQ Q8IAN7_PLAF7/265-389 PKCHFLITSYTPITIDK....HISNVQKTTVLDVMKRLLHTKNIMV..SAPVRR........GMYISILN.IIRGETDPTQVHKGLQRIRDRKL..VNFIKWNPASIQVTLAKQSPHVVSQH.....KVCGLMMANHTSISTLFERC.. Q23FR3_TETTS/263-388 PKCHFLMTGYTPISIDR....HIKTIRKTTVLDVMRRLLQTKNIMV..SASTKK........GQYISIMN.VIQGEVDASQIHKSLQRIRERKL..ANFINWGPASIQVALSKKSPYIETSH.....KVSGLMLANHTSIHTLFEKII. A8INY3_CHLRE/264-398 PRCHFLMTGYTPLTAENAAGQVTSNIRKTTVLDVMRRLLQPKNIMV..STHTKSRD...IANAKYISILN.IIQGEVDPSQVHKSLQRIRERKQ..ANFIEWGPASIQVALSKKSPYVQTAH.....RVSGLMLANHTSVRHLFNKVL. TBG_EMENI/263-392 PRSHFLLTSYTPFTGDNI..DQAKTVRKTTVLDVMRRLLQPKNRMV..SINPSK.......SSCYISILN.IIQGEADPTDVHKSLLRIRERRL..ASFIPWGPASIQVALTKKSPYIQNTH.....RVSGLMLANHTSVATLFKRIVQ TBG_SCHPO/264-393 PRCHFLLTSYTPFTNQQV..EEAKAIRKTTVLDVMRRLLLPKNQMV..SVNPSK.......KSCFISILD.IIQGEADPADVHKSLLRIRERRY..ASFIPWGPASIQVALSKKSPYIKTNH.....RVSGLMLANHTSIASLFKRTLD TBG2_DROME/264-394 PQLHFLMTGYTPLMSDCE...TKTSVRKTTVLDVMRRLLQPKNMMV..SALTDKQ.....SRQCFVSILN.IIQGEVDPSQVHKSLQRIRERKL..ANFIPWGPASIQVALPRSSPYVQSAH.....KVSGLMMANHTGISSLFKRALA TBG1_HUMAN/264-393 PRLHFLMTGYTPLTTDQ....SVASVRKTTVLDVMRRLLQPKNVMV..STGRDRQ.....TNHCYIAILN.IIQGEVDPTQVHKSLQRIRERKL..ANFIPWGPASIQVALSRKSPYLPSAH.....RVSGLMMANHTSISSLFERTCR #=GR TBG1_HUMAN/264-393 SS SS--EEEEEEC--S---....-----S---HHHHHHHTTSGGGBSS..-------.....----EEEEEE.EEESS--CCHHHHHHHHHHHCT-..S-B-SSS---EEEEEE---TT-----.....--EEEEEEEEGGGHHHHHHHHH D6XD01_TRYB2/266-392 PRCHFVCTGYTPTTLDTS..NIQSSVQKTSVHDVMRRLLMPKNMMV..STSMKS........GCYISLLN.LIQGDVDPAQVHRSLERIRERSP...NFIPWGPASIQVILSKKSPYLDTRH.....RVSGLVMANHTSISSLFQRTL. TBG_YEAST/263-392 PELHFLSPSFTPFTSDYI..HDDIAHKGHSSYDVMLDLLDPSNSLV..STAMNN........PTYFNVYN.TIIGNVEPRQISRAMTKLQQRIK....FPSWSSSAMHVNIGRRSPYLPLQPN..ENEVSGMMLSNMSTVVNVFENACN #=GR TBG_YEAST/263-392 SS TTC-EEEEEEESS-SSSS..SSS-----HHHHHHHHHSSSSSSS-S..STSTSS........SS-EEEEE.EEEESSS-HHHHHHHHHHHHHHT....SS--BTTTC--EEEEEEE--TTSSS..SS-SEEEEEEEEGGGHHHHHHHHH TBE_MOUSE/294-414 PKLHYLVSSLTPLYTLA.....DVNIPPRRLDQMFSDAFSKDHQLI..QADPRH........SLYLACAL.IVRGNVQISDLRRNIERLKPALQ....FVSWNQEGWKTSLCSVPPVGHSHS........LLALANNTCVKPTFMELRE Q4FKF8_TRYB2/297-426 PRLLFLTSAIAPLSVAR....HAAASAPRSVDTMIAACLDKNHQFV..DVSNGLSSALTHEAGTCLATAIVARGPQITVGDLTRNIPRIRERQK....LVYWNEDGCKTALCSVSPLGHRNS........VLMLANHCSIAQKLQSAH. L2G737_COLFN/261-380 PRLHFFTVGFAPLTTA.......AAYQNLGVAELTQQMFDPKNVMS..ASDFRN........GRFLTCSA.IYRGKVSTKQIEEQIRGVQAKNS..AYFVEWIPNNVQTAHCSIPPVGMNAS........STFIGNSTAIQDIFRRVG. TBB_SCHPO/261-383 PRLHFFMVGFAPLAAIG.....SSSFQAVSVPELTQQMFDANNMMV..AADPRH........GRYLTVAA.LFRGKVSMKEVDEQIRSVQTKNS..AYFVEWIPDNVLKAVCSVPPKDLKMS........ATFIGNSTSIQEIFRRLGD #=GR TBB_SCHPO/261-383 SS TT--EEEEEEE----ST.....TTTTS---HHHHHHHHT-GGGBSS..SS-TTT........S-BSEEEE.EEEES--HHHHHHHHHHHHHHTT..TTB-SSS-S-EEEEEE-S--SS-SEE........EEEEEE-S-HHHHHHHHHH TBB_DICDI/266-388 PRLHFFLVGFAPLTAKG.....ASSYNRITVPELTQQMFDAKNMMA..ASDPHN........GKYLTASA.LFRGKIFTKEVDEQMHNIQTKNS..SYFVEWIPHNIKSSICDIPPKGTPMA........VTFIGNNTAIQDLFKRISI TBB_ENCCU/261-382 PRLHFFVAGFAPLIAIG.....TQKFKTYSVSELTQQMFDSKNMMT..ACDPRK........GRYLTVAA.MFRGKISMKDVDEQMSMVQSKNS..SLFVEWIPSNVKTAVCDIAPTGLEMS........ATFVGNTTSIQELFKRIS. TBB_STRPU/106-227 PRLHFFMPGFAPLTSRG.....SQQYRALTVPELTQQMFDAKNMMA..ACDPRH........GRYLTVAA.IFRGRMSMKEVDEQMLNVQNKNS..SYFVEWIPNNVKTAVCDIPPRGLKMS........ATFIGNSTAIQELFKRIS. TBBP_DROME/260-382 PRLHFLIPGFAPLVTCK.....QQQFSKGTVSELVQQIFYSNNLLC..AIDLRK........GKLLTAAG.IFRGRMSPREVDQLMTGVRNKNI..NNFVDWIPNNIKTAICDIPPRGLKMS........ATFIGNTTAIQTLFQRLLD F6HWX4_VITVI/87-217 PRIHFMLSSYAPVISAE.....KAYHEQLSVAEITNSAFEPSSMMA..KCDPRH........GKYMACCL.MYRGDVVPKDVNAAVATIKTKRT..IQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMISNSTSVAEVFSRIDH P91873_CAEEL/269-399 PRIHFPLVTYAPLVSAE.....RASHEQNTVSDMTHACFEPGYQMV..KCDPRR........GKYMAVCL.LYRGDVVPKDINSAIAAVKTKRT..VQFVEWCPTGFKVGINYQPPTVVPGGDLGKQTRSVCMISNTTAIAEAWARLDH V5E7D2_KALBG/262-391 PRIHFPLATYAPILSAA.....KAGHEQNSVAEMTFSSFEKGNQMV..KADPRD........GKFMACCL.LYRGDVVPKDVNSAVATIKTKRT..IQFVDWCPTGFKIGICNEPPTTVPGGDLAKVSRSLCMLANTTAIAGAWGRLD. K1WWQ1_MARBU/263-392 PRIHFPLVAYSPVVSAA.....KASHEANSVQEISMSCFEPNNQMV..KCDPRN........GKYMATCL.LYRGDVVTKDVHGAVATLKTKRT..IQFVDWCPTGFKIGICYQPPQMVPNGDLAKVNRAVCMLSNTTAIAEAWSALS. TBA2_SCHPO/263-393 PRIHFPLVTYAPIVSAA.....KAFHESNSVQEITNQCFEPYNQMV..KCDPRA........GRYMATCL.LYRGDVIPRDVQAAVTTIKAKRT..IQFVDWCPTGFKIGICDRPPQHIEGSEIAKVDRAVCMLSNTTSIAEAWSRLDH TBA1_YEAST/264-394 PRIHFPLVSYSPVLSKS.....KAFHESNSVSEITNACFEPGNQMV..KCDPRD........GKYMATCL.LYRGDVVTRDVQRAVEQVKNKKT..VQLVDWCPTGFKIGICYEPPTATPNSQLATVDRAVCMLSNTTSIAEAWKRIDR #=GR TBA1_YEAST/264-394 SS SS----EEEEE---BTT.....TTTC----HHHHHHHTCSGGGBSS..SS-TTT........S-EEEEEE.EEEES--HHHHHHHHHHHHHTT-..S-B-TTSSS-EEEEEE-S-----TTSSB---SEEEEEEEEEGGGHHHHHHHHH TBA4_DROME/274-404 PRIHFPLVAYAPLMSAE.....RSAHEQHAITTLTNACFESSNMMV..KCDPRA........GKFMACCM.LYRGDVVPKDVNAAVSAIKSKRH..IQFVDWCPTGFKIGINYEKPAFVPDGDLAKTSRACCMLSNTTAISVAFSNLSY TBA_ENCCU/259-388 PRIHFPLVAYSPMLSKE.....KAAHEKLSVQEITNACFEPQNQMV..RCDTRK........GKYMACCL.LFRGDVNPKEANNATANVKAKRT..NQFVEWCPTGFKVGINSRKPTVLDGEAMAEVSRAVCALSNTTAISEAWKRLN. S7XG08_SPRLO/260-389 PRIHFPLVAYSPMLSRE.....RASHEQLSVQEITSACFDPKNQMV..KCDPRN........GKYMACCL.LFRGNVNPKDVNQATSLVKSKRA..NQFVEWCPTGFKIGINDRKPYVFKDGAMAPVDRAVCMLSNTTAISEAWKRLN. TBA2_EMENI/265-395 PRIHYPLISYAPVISSN.....RSSHESFKVQDLTLQCAEPNNQMV..VCDPRN........GKYMAVAL.LYRGDCVPRDCTQAIASLKAKAS..FNLVEWCPTGFKVGINYQKPARVPGSELAPVDRSVSMLSNTTAISEAWSRLDH O18154_CAEEL/260-388 PRIHFPLVAYNPLISS.......AHHEFLSVDEITKSCFEASNQMV..KCDPKH........GKYMAVCL.LYRGDVVPKDVSAAIKSIKTQRS..VQFVDWCPTGFKVGLNYQPPTVIPGGDMAKVPRAVCMLSNTTAIAEAWQRLDY TBAL3_HUMAN/270-400 PRIHFPMTAFAPIVSAD.....KAYHEQFSVSDITTACFESSNQLV..KCDPRL........GKYMACCL.LYRGDVVPKEVNAAIAATKSRHS..VQFVDWCPTGFKVGINNRPPTVMPGGDLAKVHRSICMLSNTTAIVEAWARLDH #=GC SS_cons TTC-EEEEEEESSSCSTS..SSTTTCS-HHHHHHHHHTTSGGGBSS..SSSTTT........SSEEEEEE.EEEESSSHHHHHHHHHHHHHHTT..STBSSSSTSTEEEEEEESECTSTTCSSB-SSSCEEEEEEEEGGGHHHHHHHHH #=GC seq_cons PRlHFhhsuYuPlsosp.....pushcptoVt-lspphhcspN.MV..pscs+p........G+Yhussh.laRG-VsP+-Vppulppl+s++p..spFV-WsPsuhKlulsppsPhshssu.....phushMLuNsTuIsphFpRls. //