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15  structures 276  species 1  interaction 364  sequences 5  architectures

Family: P21-Arc (PF04062)

Summary: ARP2/3 complex ARPC3 (21 kDa) subunit

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This is the Wikipedia entry entitled "ARPC3". More...

ARPC3 Edit Wikipedia article

Actin related protein 2/3 complex, subunit 3, 21kDa

PDB rendering based on 1k8k.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ARPC3; ARC21; p21-Arc
External IDs OMIM604225 MGI1928375 HomoloGene4178 GeneCards: ARPC3 Gene
RNA expression pattern
PBB GE ARPC3 208736 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10094 56378
Ensembl ENSG00000111229 ENSMUSG00000029465
UniProt O15145 Q9JM76
RefSeq (mRNA) NM_005719 NM_019824
RefSeq (protein) NP_005710 NP_062798
Location (UCSC) Chr 12:
110.87 – 110.89 Mb
Chr 5:
122.39 – 122.41 Mb
PubMed search [1] [2]
ARP2/3 complex ARPC3 (21 kDa) subunit
PDB 1u2v EBI.jpg
crystal structure of arp2/3 complex with bound adp and calcium
Identifiers
Symbol P21-Arc
Pfam PF04062
InterPro IPR007204

Actin-related protein 2/3 complex subunit 3 is a protein that in humans is encoded by the ARPC3 gene.[1][2][3]

This gene encodes one of seven subunits of the Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p21 subunit, has yet to be determined.[3]

References[edit]

Further reading[edit]

External links[edit]



This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

ARP2/3 complex ARPC3 (21 kDa) subunit Provide feedback

The seven component ARP2/3 actin-organising complex is involved in actin assembly and function.

Literature references

  1. Gournier H, Goley ED, Niederstrasser H, Trinh T, Welch MD; , Mol Cell 2001;8:1041-1052.: Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity. PUBMED:11741539 EPMC:11741539


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR007204

The Arp2/3 complex is a seven-protein assembly that is critical for actin nucleation and branching in cells. Arp2/3 nucleates new actin filaments while bound to existing filaments, thus creating a branched network [PUBMED:15040784]. The complex consists of Arp2, Arp3, p41, p34, p21, p20 and p16. Subunits p34 and p20 constitute the core of the structure, with the remaining subunits located peripherally [PUBMED:11741539]. This entry describes the p21 subunit. Proteins such as WASp and Scar1 may mediate receptor signalling through interactions with p21-Arc, resulting in the activation of Arc2/3 complex activity [PUBMED:11162547].

Gene Ontology

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Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(29)
Full
(364)
Representative proteomes NCBI
(331)
Meta
(3)
RP15
(73)
RP35
(121)
RP55
(183)
RP75
(231)
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Format an alignment

  Seed
(29)
Full
(364)
Representative proteomes NCBI
(331)
Meta
(3)
RP15
(73)
RP35
(121)
RP55
(183)
RP75
(231)
Alignment:
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Sequence:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(29)
Full
(364)
Representative proteomes NCBI
(331)
Meta
(3)
RP15
(73)
RP35
(121)
RP55
(183)
RP75
(231)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

External links

MyHits provides a collection of tools to handle multiple sequence alignments. For example, one can refine a seed alignment (sequence addition or removal, re-alignment or manual edition) and then search databases for remote homologs using HMMER3.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

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Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_6413 (release 7.3);
Previous IDs: none
Type: Family
Author: Wood V, Finn RD
Number in seed: 29
Number in full: 364
Average length of the domain: 170.20 aa
Average identity of full alignment: 48 %
Average coverage of the sequence by the domain: 94.42 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.0 25.0
Trusted cut-off 40.0 40.0
Noise cut-off 18.3 16.9
Model length: 175
Family (HMM) version: 9
Download: download the raw HMM for this family

Species distribution

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Interactions

There is 1 interaction for this family. More...

Actin

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the P21-Arc domain has been found. There are 15 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.

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