Summary: DsrH like protein
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DsrH is involved in oxidation of intracellular sulphur in the phototrophic sulphur bacterium Chromatium vinosum D .
Pott AS, Dahl C; , Microbiology 1998;144:1881-1894.: Sirohaem sulfite reductase and other proteins encoded by genes at the dsr locus of Chromatium vinosum are involved in the oxidation of intracellular sulfur. PUBMED:9695921 EPMC:9695921
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This tab holds annotation information from the InterPro database.
InterPro entry IPR007215
The three proteins TusB, TusC, and TusD form a heterohexamer responsible for a sulphur relay reaction. In large numbers of proteobacterial species, this complex acts on a Cys-derived persulphide moiety, delivered by the cysteine desulphurase IscS to TusA, then to TusBCD. The activated sulphur group is then transferred to TusE (DsrC), then by MnmA (TrmU) for modification of an anticodon nucleotide in tRNAs for Glu, Lys, and Gln.
The sulphur relay complex TusBCD is also found, under the designation DsrEFH, in phototrophic and chemotrophic sulphur bacteria, such as Chromatium vinosum. In these organisms, it seems the primary purpose is related to sulphur flux, such as oxidation from sulphide to molecular sulphur to sulphate [PUBMED:9695921].
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|Cellular component||cytoplasm (GO:0005737)|
|Biological process||tRNA wobble position uridine thiolation (GO:0002143)|
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Curation and family details
|Author:||Kerrison ND, Finn RD|
|Number in seed:||66|
|Number in full:||948|
|Average length of the domain:||86.00 aa|
|Average identity of full alignment:||41 %|
|Average coverage of the sequence by the domain:||91.11 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the DsrH domain has been found. There are 13 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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