Summary: Fatty acid hydroxylase superfamily
Fatty acid hydroxylase superfamily Provide feedback
This superfamily includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways . This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif. Members of this family are integral membrane proteins.
Arthington BA, Bennett LG, Skatrud PL, Guynn CJ, Barbuch RJ, Ulbright CE, Bard M; , Gene 1991;102:39-44.: Cloning, disruption and sequence of the gene encoding yeast C-5 sterol desaturase. PUBMED:1864507 EPMC:1864507
Bard M, Bruner DA, Pierson CA, Lees ND, Biermann B, Frye L, Koegel C, Barbuch R; , Proc Natl Acad Sci U S A 1996;93:186-190.: Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase. PUBMED:8552601 EPMC:8552601
Aarts MG, Keijzer CJ, Stiekema WJ, Pereira A; , Plant Cell 1995;7:2115-2127.: Molecular characterization of the CER1 gene of arabidopsis involved in epicuticular wax biosynthesis and pollen fertility. PUBMED:8718622 EPMC:8718622
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR006694
This superfamily includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways [PUBMED:8718622]. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif. Members of this family are integral membrane proteins.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||iron ion binding (GO:0005506)|
|oxidoreductase activity (GO:0016491)|
|Biological process||fatty acid biosynthetic process (GO:0006633)|
|oxidation-reduction process (GO:0055114)|
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Curation and family details
|Seed source:||Pfam-B_7847 (release 7.3) & DOMO:DM04600 & Pfam-B_905 (release 4.1);|
|Author:||Bateman A, Wood V, Finn RD|
|Number in seed:||122|
|Number in full:||4549|
|Average length of the domain:||115.30 aa|
|Average identity of full alignment:||21 %|
|Average coverage of the sequence by the domain:||37.33 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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