Summary: Sec34-like family
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Sec34-like family Provide feedback
Whyte JR, Munro S; , Dev Cell 2001;1:527-537.: The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic. PUBMED:11703943 EPMC:11703943
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR007265
Sec34 and Sec35 form a sub-complex in a seven-protein complex that includes Dor1. This complex is thought to be important for tethering vesicles to the Golgi [PUBMED:11703943].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||membrane (GO:0016020)|
|cis-Golgi network (GO:0005801)|
|Biological process||intracellular protein transport (GO:0006886)|
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This clan contains families that are involved in intracellular transport and signalling. Arfaptins are proteins which interact with small GTPases involved in vesicular budding at the Golgi complex. They form an elongated dimer of three helix coiled coils and are structurally very similar to the BAR domain . The Sec34 family is involved in tethering vesicles to the Golgi .
The clan contains the following 9 members:Arfaptin BAR BAR_2 BAR_3_WASP_bdg FAM92 IMD Pil1 Sec34 Vps5
We make a range of alignments for each Pfam-A family:
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1Cannot generate PP/Heatmap alignments for seeds; no PP data available
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Curation and family details
|Seed source:||Pfam-B_16464 (release 7.3);|
|Author:||Wood V, Finn RD|
|Number in seed:||3|
|Number in full:||293|
|Average length of the domain:||151.10 aa|
|Average identity of full alignment:||29 %|
|Average coverage of the sequence by the domain:||19.38 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||10|
|Download:||download the raw HMM for this family|
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