Summary: Nucleotide-sugar transporter
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Nucleotide-sugar transporter Provide feedback
This family of membrane proteins transport nucleotide sugars from the cytoplasm into Golgi vesicles. P78382 transports CMP-sialic acid, P78381 transports UDP-galactose and Q9Y2D2 transports UDP-GlcNAc.
Internal database links
SCOOP: | Bax1-I CRT-like EamA EmrE Mg_trans_NIPA Multi_Drug_Res PUNUT SLC35F TPT UAA |
External database links
Transporter classification: | 2.A.7 |
This tab holds annotation information from the InterPro database.
InterPro entry IPR007271
This family of membrane proteins transport nucleotide sugars from the cytoplasm into golgi vesicles. SLC35A1 (SWISSPROT) transports CMP-sialic acid, SLC35A2 (SWISSPROT) transports UDP-galactose and SLC35A3 (SWISSPROT) transports UDP-GlcNAc [PUBMED:25210595].
Gene Ontology
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
Cellular component | integral component of membrane (GO:0016021) |
Golgi membrane (GO:0000139) | |
Molecular function | pyrimidine nucleotide-sugar transmembrane transporter activity (GO:0015165) |
Biological process | pyrimidine nucleotide-sugar transmembrane transport (GO:0090481) |
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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Pfam Clan
This family is a member of clan DMT (CL0184), which has the following description:
This clan contains a variety of transporters which have 4, 5, 9 or 10 membrane spanning helices. Many of the 10 membrane spanning transporters appear to be a duplication of the 5 spanning unit [1]. Many of these families contain a characteristic glycine rich motif close to the C-terminus.
The clan contains the following 21 members:
CRCB CRT-like CSG2 DMT_6 DMT_YdcZ EamA EmrE Mg_trans_NIPA Multi_Drug_Res Nuc_sug_transp PUNUT RhaT SLC35F Sugar_transport TMEM144 TMEM234 TPT UAA UPF0060 Ureide_permease ZipAlignments
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...
View options
We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (9) |
Full (5420) |
Representative proteomes | UniProt (8775) |
NCBI (10916) |
Meta (54) |
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RP15 (965) |
RP35 (2321) |
RP55 (3749) |
RP75 (5386) |
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key:
available,
not generated,
— not available.
Format an alignment
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
Seed (9) |
Full (5420) |
Representative proteomes | UniProt (8775) |
NCBI (10916) |
Meta (54) |
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---|---|---|---|---|---|---|---|---|---|
RP15 (965) |
RP35 (2321) |
RP55 (3749) |
RP75 (5386) |
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Raw Stockholm | |||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
Trees
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Curation
Seed source: | Pfam-B_2311 (release 7.3) |
Previous IDs: | none |
Type: | Family |
Sequence Ontology: | SO:0100021 |
Author: |
Bateman A |
Number in seed: | 9 |
Number in full: | 5420 |
Average length of the domain: | 256.10 aa |
Average identity of full alignment: | 24 % |
Average coverage of the sequence by the domain: | 70.51 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 315 | ||||||||||||
Family (HMM) version: | 16 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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Selections
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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Nuc_sug_transp domain has been found. There are 8 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.
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