Summary: Mannosyltransferase (PIG-V)
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Mannosyltransferase (PIG-V) Provide feedback
This is a family of eukaryotic ER membrane proteins that are involved in the synthesis of glycosylphosphatidylinositol (GPI), a glycolipid that anchors many proteins to the eukaryotic cell surface. Proteins in this family are involved in transferring the second mannose in the biosynthetic pathway of GPI  .
Kang JY, Hong Y, Ashida H, Shishioh N, Murakami Y, Morita YS, Maeda Y, Kinoshita T; , J Biol Chem 2005;280:9489-9497.: PIG-V Involved in Transferring the Second Mannose in Glycosylphosphatidylinositol. PUBMED:15623507 EPMC:15623507
Fabre AL, Orlean P, Taron CH; , FEBS J 2005;272:1160-1168.: Saccharomyces cerevisiae Ybr004c and its human homologue are required for addition of the second mannose during glycosylphosphatidylinositol precursor assembly. PUBMED:15720390 EPMC:15720390
This tab holds annotation information from the InterPro database.
InterPro entry IPR007315
Proteins in this family are mannosyltransferases, which are involved in glycosylphosphatidylinositol-anchor biosynthesis. They are responsible for the transfer of the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly [PUBMED:15720390, PUBMED:15623507, PUBMED:17615295].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||transferase activity, transferring hexosyl groups (GO:0016758)|
|Biological process||GPI anchor biosynthetic process (GO:0006506)|
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This is the GT-C clan that contains diverse glycosyltransferases that possess 8-13 predicted transmembrane segments .
The clan contains the following 19 members:ALG3 Alg6_Alg8 Arabinose_trans DIE2_ALG10 DUF2029 DUF2079 DUF2142 DUF2723 EpsG Glucan_synthase Glyco_transf_22 Mannosyl_trans Mannosyl_trans2 PIG-U PMT PMT_2 PTPS_related STT3 YfhO
We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Pfam-B_9248 (release 7.3);|
|Author:||Wood V, Finn RD, Mistry J|
|Number in seed:||3|
|Number in full:||571|
|Average length of the domain:||325.20 aa|
|Average identity of full alignment:||21 %|
|Average coverage of the sequence by the domain:||80.97 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 11927849 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||10|
|Download:||download the raw HMM for this family|
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