Summary: Periplasmic glucan biosynthesis protein, MdoG
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Periplasmic glucan biosynthesis protein, MdoG Provide feedback
This family represents MdoG, a protein that is necessary for the synthesis of periplasmic glucans. The function of MdoG remains unknown. It has been suggested that it may catalyse the addition of branches to a linear glucan backbone.
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This tab holds annotation information from the InterPro database.
InterPro entry IPR007444
Membrane-derived oligosaccharides (MDO) are members of a family of glucans found in the periplasmic space of Gram-negative bacteria. MdoG has been shown to be necessary for the synthesis of MDO [PUBMED:7934824], but its exact function is not known yet. MdoD, an MdoG paralog, is a twin-arginine-dependent periplasmic protein that controls osmoregulated periplasmic glucan backbone structures [PUBMED:15175282]. This entry represents the functional portion of the protein and excludes the N-terminal signal sequence.
|Cellular component||periplasmic space (GO:0042597)|
|Biological process||carbohydrate biosynthetic process (GO:0016051)|
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This clan is composed of a beta-sandwich that was first observed in domain 5 of beta-galactosidase, then as the central domain of copper amine oxidase, the C-terminal domain of chondroitinase, the C-terminal domain of hyaluronate lyase, the N-terminal domain of maltose phosphorylase and in Galactose Mutarotase . All these enzymes act on a sugar substrate.
The clan contains the following 11 members:Aldose_epim Bgal_small_N DUF4432 Gal_mutarotas_2 Glyco_hyd_65N_2 Glyco_hydro_38C Glyco_hydro_65N Lyase_8 MdoG Rhamnogal_lyase YidC_periplas
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Curation and family details
|Number in seed:||4|
|Number in full:||1625|
|Average length of the domain:||475.30 aa|
|Average identity of full alignment:||48 %|
|Average coverage of the sequence by the domain:||91.60 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||7|
|Download:||download the raw HMM for this family|
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There is 1 interaction for this family. More...
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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the MdoG domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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