Summary: Mss4 protein
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Mss4 protein Provide feedback
No Pfam abstract.
Burton J, Roberts D, Montaldi M, Novick P, De Camilli P; , Nature 1993;361:464-467.: A mammalian guanine-nucleotide-releasing protein enhances function of yeast secretory protein Sec4. PUBMED:8429887 EPMC:8429887
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External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR007515
Guanine nucleotide exchange factor MSS4 (Rab interacting factor) is a guanine-nucleotide releasing protein that acts on members of the SCE4/YPT1/RAB subfamily. It stimulates release of GDP and may play a role in vesicular transport.
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Molecular function||guanyl-nucleotide exchange factor activity (GO:0005085)|
|Biological process||small GTPase mediated signal transduction (GO:0007264)|
- the number of sequences which exhibit this architecture
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This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
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We make a range of alignments for each Pfam-A family:
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Curation and family details
|Seed source:||Wood V|
|Author:||Bateman A, Wood V|
|Number in seed:||29|
|Number in full:||262|
|Average length of the domain:||99.30 aa|
|Average identity of full alignment:||32 %|
|Average coverage of the sequence by the domain:||58.03 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
|Download:||download the raw HMM for this family|
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There are 2 interactions for this family. More...
We determine these interactions using iPfam, which considers the interactions between residues in three-dimensional protein structures and maps those interactions back to Pfam families. You can find more information about the iPfam algorithm in the journal article that accompanies the website.
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Mss4 domain has been found. There are 5 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein seqence.
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