Summary: Herpesvirus UL17 protein
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Herpesvirus UL17 protein Provide feedback
UL17 protein is required for DNA cleavage and packaging in herpes viruses. It has been shown to associate with immature B-type capsids  and is required for the the localisation of capsids and capsid proteins to the intranuclear sites where viral DNA is cleaved and packaged . In the virion, UL17 is a component of the tegument, which is a protein layer surrounding the viral capsid .
Goshima F, Watanabe D, Takakuwa H, Wada K, Daikoku T, Yamada M, Nishiyama Y; , Arch Virol 2000;145:417-426.: Herpes simplex virus UL17 protein is associated with B capsids and colocalizes with ICP35 and VP5 in infected cells. PUBMED:10752563 EPMC:10752563
Taus NS, Salmon B, Baines JD; , Virology 1998;252:115-125.: The herpes simplex virus 1 UL 17 gene is required for localization of capsids and major and minor capsid proteins to intranuclear sites where viral DNA is cleaved and packaged. PUBMED:9875322 EPMC:9875322
Salmon B, Cunningham C, Davison AJ, Harris WJ, Baines JD; , J Virol 1998;72:3779-3788.: The herpes simplex virus type 1 U(L)17 gene encodes virion tegument proteins that are required for cleavage and packaging of viral DNA. PUBMED:9557660 EPMC:9557660
This tab holds annotation information from the InterPro database.
InterPro entry IPR007640This entry represents a group of capsid vertex components from Herpesvirus, including UL17 from Human herpesvirus 1. UL17 is a capsid vertex-specific component that plays a role during viral DNA encapsidation, assuring correct genome cleavage and presumably stabilizing capsids that contain full-length viral genomes [PUBMED:21632758].
|Cellular component||virion (GO:0019012)|
|Biological process||DNA packaging (GO:0006323)|
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|Number in seed:||36|
|Number in full:||17|
|Average length of the domain:||455.40 aa|
|Average identity of full alignment:||17 %|
|Average coverage of the sequence by the domain:||94.41 %|
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build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 26740544 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||11|
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