Summary: Dec-1 repeat
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Dec-1 repeat Provide feedback
The defective chorion-1 gene (dec-1) in Drosophila encodes follicle cell proteins necessary for proper eggshell assembly. Multiple products of the dec-1 gene are formed by alternative RNA splicing and proteolytic processing [1]. Cleavage products include S80 (80 kDa) which is incorporated into the eggshell, and further proteolysis of S80 gives S60 (60 kDa). This repeat is usually found in 12 copies in the central region of the protein. Its function is unknown. Length polymorphisms of Dec-1 have been observed in wild-type strains, and are caused by changes in the numbers of the first five repeats [2].
Literature references
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Waring GL, Hawley RJ, Schoenfeld T; , Dev Biol 1990;142:1-12.: Multiple proteins are produced from the dec-1 eggshell gene in Drosophila by alternative RNA splicing and proteolytic cleavage events. PUBMED:1699826 EPMC:1699826
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Andersson S, Lambertsson A; , J Mol Evol 1993;36:536-544.: Evolution of the dec-1 eggshell locus in Drosophila. II. Intraspecific DNA sequence analysis reveals length mutations in a repetitive region in D. melanogaster. PUBMED:8350348 EPMC:8350348
This tab holds annotation information from the InterPro database.
InterPro entry IPR006718
The defective chorion-1 gene (dec-1) in Drosophila encodes follicle cell proteins necessary for proper eggshell assembly. Multiple products of the dec-1 gene are formed by alternative RNA splicing and proteolytic processing [PUBMED:1699826]. Cleavage products include S80 (80kDa) which is incorporated into the eggshell, and further proteolysis of S80 gives S60 (60kDa).
This repeat is usually found in 12 copies in the central region of the protein. Its function is unknown. Length polymorphisms of Dec-1 have been observed in wild-type strains, and are caused by changes in the numbers of the first five repeats [PUBMED:8350348].
Gene Ontology
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
Cellular component | extracellular region (GO:0005576) |
chorion (GO:0042600) | |
Molecular function | structural constituent of chorion (GO:0005213) |
Biological process | chorion-containing eggshell formation (GO:0007304) |
Domain organisation
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Alignments
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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (9) |
Full (84) |
Representative proteomes | UniProt (245) |
NCBI (390) |
Meta (1) |
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RP15 (24) |
RP35 (24) |
RP55 (24) |
RP75 (44) |
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
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Seed (9) |
Full (84) |
Representative proteomes | UniProt (245) |
NCBI (390) |
Meta (1) |
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RP15 (24) |
RP35 (24) |
RP55 (24) |
RP75 (44) |
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Raw Stockholm | |||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
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Trees
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
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Curation
Seed source: | DOMO:DM04594; |
Previous IDs: | DEC-1_REPEAT; |
Type: | Repeat |
Sequence Ontology: | SO:0001068 |
Author: |
Kerrison ND |
Number in seed: | 9 |
Number in full: | 84 |
Average length of the domain: | 26.10 aa |
Average identity of full alignment: | 75 % |
Average coverage of the sequence by the domain: | 11.97 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 27 | ||||||||||||
Family (HMM) version: | 15 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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