Summary: PA26 p53-induced protein (sestrin)
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PA26 p53-induced protein (sestrin) Provide feedback
PA26 is a p53-inducible protein. Its function is unknown. It has similarity to PF04636 in its N-terminus.
Internal database links
|SCOOP:||SDA1 Pol_alpha_B_N MIP-T3 SpoIIIAH PCYCGC SID-1_RNA_chan SOBP CKAP2_C DUF4614 PNISR|
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR006730
Sestrins (Sesns) are involved in ROS (reactive oxygen species) regulation. In mammals, there are three Sestrins (Sesn1, Sesn2, and Sesn3), while in Drosophila melanogaster and C. elegans, there is only one Sesn [PUBMED:20712410]. The N-terminal of Sesns shares protein sequence and structural similarity with the C-terminal alpha-helical domain of the AhpD protein from Mycobacterium tuberculosis. Interestingly, AhpD is a component of alkyl-hydroperoxide reductase participating in defense against ROS and ROS produced by host immune cells [PUBMED:11799204].
Sesn1 (also known as p53-activated gene 26, PA26) was first identified as a target of the p53 protein through a screen [PUBMED:7938006]. Subsequently, Sesn2 (also known as hypoxia-inducible gene 95, Hi95) was identified by microarray-based analysis of novel genes activated by prolonged hypoxia [PUBMED:12203114]. Both the Sesn1 and Sesn2 genes can be activated by genotoxic stress in a p53-dependent manner [PUBMED:7938006]. All three mammalian Sesns can be activated by the transcription factor forkhead transcription factor (FoxO3A) and FoxO1, members of the FoxO gene family [PUBMED:20712410].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||nucleus (GO:0005634)|
|Biological process||regulation of response to reactive oxygen species (GO:1901031)|
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Curation and family details
|Seed source:||Pfam-B_5416 (release 7.5)|
|Number in seed:||33|
|Number in full:||511|
|Average length of the domain:||365.30 aa|
|Average identity of full alignment:||42 %|
|Average coverage of the sequence by the domain:||81.73 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
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