Summary: BAF1 / ABF1 chromatin reorganising factor
BAF1 / ABF1 chromatin reorganising factor Provide feedback
ABF1 is a sequence-specific DNA binding protein involved in transcription activation, gene silencing and initiation of DNA replication. ABF1 is known to remodel chromatin, and it is proposed that it mediates its effects on transcription and gene expression by modifying local chromatin architecture . These functions require a conserved stretch of 20 amino acids in the C-terminal region of ABF1 (amino acids 639 to 662 S. cerevisiae (P14164)) . The N-terminal two thirds of the protein are necessary for DNA binding, and the N-terminus (amino acids 9 to 91 in S. cerevisiae) is thought to contain a novel zinc-finger motif which may stabilise the protein structure .
Miyake T, Loch CM, Li R; , Mol Cell Biol 2002;22:505-516.: Identification of a multifunctional domain in autonomously replicating sequence-binding factor 1 required for transcriptional activation, DNA replication, and gene silencing. PUBMED:11756546 EPMC:11756546
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR006774ABF1 is a sequence-specific DNA binding protein involved in transcription activation, gene silencing and initiation of DNA replication. ABF1 is known to remodel chromatin, and it is proposed that it mediates its effects on transcription and gene expression by modifying local chromatin architecture [PUBMED:11756546]. These functions require a conserved stretch of 20 amino acids in the C-terminal region of ABF1 (amino acids 639 to 662 Saccharomyces cerevisiae (SWISSPROT)) [PUBMED:11756546]. The N-terminal two thirds of the protein are necessary for DNA binding, and the N terminus (amino acids 9 to 91 in S. cerevisiae) is thought to contain a novel zinc-finger motif which may stabilise the protein structure [PUBMED:1594441].
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|Cellular component||nucleus (GO:0005634)|
|Molecular function||DNA binding (GO:0003677)|
|Biological process||chromatin remodeling (GO:0006338)|
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|Number in seed:||1|
|Number in full:||85|
|Average length of the domain:||184.60 aa|
|Average identity of full alignment:||29 %|
|Average coverage of the sequence by the domain:||60.95 %|
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build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||9|
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