Summary: Apolipoprotein A-II (ApoA-II)
This is the Wikipedia entry entitled "APOA2". More...
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APOA2 Edit Wikipedia article
|Symbols||; Apo-AII; ApoA-II; apoAII|
|RNA expression pattern|
structures of apolipoprotein a-ii and a lipid surrogate complex provide insights into apolipoprotein-lipid interactions
This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia.
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles. [Â§ 1]
- The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".
- Tsao YK, Wei CF, Robberson DL, Gotto AM Jr, Chan L (Jan 1986). "Isolation and characterization of the human apolipoprotein A-II gene. Electron microscopic analysis of RNA:DNA hybrids, nucleotide sequence, identification of a polymorphic MspI site, and general structural organization of apolipoprotein genes". J Biol Chem 260 (28): 15222â€“31. PMID 2415515.
- "Entrez Gene: APOA2 apolipoprotein A-II".
- Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (January 1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". J. Lipid Res. 39 (1): 152â€“61. PMID 9469594.
- Blanco-Vaca F, EscolÃ -Gil JC, MartÃn-Campos JM, Julve J (2002). "Role of apoA-II in lipid metabolism and atherosclerosis: advances in the study of an enigmatic protein.". J. Lipid Res. 42 (11): 1727â€“39. PMID 11714842.
- Kalopissis AD, Pastier D, Chambaz J (2003). "Apolipoprotein A-II: beyond genetic associations with lipid disorders and insulin resistance.". Curr. Opin. Lipidol. 14 (2): 165â€“72. doi:10.1097/01.mol.0000064047.08840.50. PMID 12642785.
- Vollmer E, Brust J, Roessner A et al. (1991). "Distribution patterns of apolipoproteins A1, A2, and B in the wall of atherosclerotic vessels.". Virchows Archiv. A, Pathological anatomy and histopathology 419 (2): 79â€“88. doi:10.1007/BF01600220. PMID 1908160.
- Deeb SS, Takata K, Peng RL et al. (1990). "A splice-junction mutation responsible for familial apolipoprotein A-II deficiency.". Am. J. Hum. Genet. 46 (4): 822â€“7. PMC 1683675. PMID 2107739.
- Gordon JI, Sims HF, Edelstein C et al. (1985). "Extracellular processing of proapolipoprotein A-II in Hep G2 cell cultures is mediated by a 54-kDa protease immunologically related to cathepsin B.". J. Biol. Chem. 260 (27): 14824â€“31. PMID 2414299.
- Lackner KJ, Law SW, Brewer HB (1985). "The human apolipoprotein A-II gene: complete nucleic acid sequence and genomic organization.". Nucleic Acids Res. 13 (12): 4597â€“608. doi:10.1093/nar/13.12.4597. PMC 321808. PMID 2989800.
- Knott TJ, Wallis SC, Robertson ME et al. (1985). "The human apolipoprotein AII gene: structural organization and sites of expression.". Nucleic Acids Res. 13 (17): 6387â€“98. doi:10.1093/nar/13.17.6387. PMC 321960. PMID 2995928.
- Chan L, Moore MN, Tsao YK (1986). "Molecular cloning and sequence analysis of human apolipoprotein A-II cDNA.". Meth. Enzymol. Methods in Enzymology 128: 745â€“52. doi:10.1016/0076-6879(86)28103-3. ISBN 978-0-12-182028-2. PMID 3088392.
- Middleton-Price HR, van den Berghe JA, Scott J et al. (1988). "Regional chromosomal localisation of APOA2 to 1q21-1q23". Hum. Genet. 79 (3): 283â€“5. doi:10.1007/BF00366253. PMID 3136074.
- Shelley CS, Sharpe CR, Baralle FE, Shoulders CC (1986). "Comparison of the human apolipoprotein genes. Apo AII presents a unique functional intron-exon junction". J. Mol. Biol. 186 (1): 43â€“51. doi:10.1016/0022-2836(85)90255-4. PMID 3935800.
- Brewer HB, Lux SE, Ronan R, John KM (1972). "Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein isolated from the high-density lipoprotein complex". Proc. Natl. Acad. Sci. U.S.A. 69 (5): 1304â€“8. doi:10.1073/pnas.69.5.1304. PMC 426687. PMID 4338591.
- Lux SE, John KM, Ronan R, Brewer HB (1973). "Isolation and characterization of the tryptic and cyanogen bromide peptides of apoLp-Gln-II (apoA-II), plasma high density apolipoprotein". J. Biol. Chem. 247 (23): 7519â€“27. PMID 4344225.
- Moore MN, Kao FT, Tsao YK, Chan L (1984). "Human apolipoprotein A-II: nucleotide sequence of a cloned cDNA, and localization of its structural gene on human chromosome 1". Biochem. Biophys. Res. Commun. 123 (1): 1â€“7. doi:10.1016/0006-291X(84)90371-1. PMID 6089788.
- Lackner KJ, Law SW, Brewer HB (1984). "Human apolipoprotein A-II: complete nucleic acid sequence of preproapo A-II". FEBS Lett. 175 (1): 159â€“64. doi:10.1016/0014-5793(84)80590-6. PMID 6090207.
- Gordon JI, Budelier KA, Sims HF et al. (1984). "Biosynthesis of human preproapolipoprotein A-II". J. Biol. Chem. 258 (22): 14054â€“9. PMID 6315718.
- Sharpe CR, Sidoli A, Shelley CS et al. (1984). "Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance". Nucleic Acids Res. 12 (9): 3917â€“32. doi:10.1093/nar/12.9.3917. PMC 318799. PMID 6328445.
- Stoffel W, KrÃ¼ger E, Deutzmann R (1983). "Cell-free translation of human liver apolipoprotein AI and AII mRNA. Processing of primary translation products". Hoppe-Seyler's Z. Physiol. Chem. 364 (3): 227â€“37. doi:10.1515/bchm2.1983.364.1.227. PMID 6407957.
- Knott TJ, Priestley LM, Urdea M, Scott J (1984). "Isolation and characterisation of a cDNA encoding the precursor for human apolipoprotein AII". Biochem. Biophys. Res. Commun. 120 (3): 734â€“40. doi:10.1016/S0006-291X(84)80168-0. PMID 6428397.
- Lackner KJ, Law SW, Brewer HB et al. (1984). "The human apolipoprotein A-II gene is located on chromosome 1". Biochem. Biophys. Res. Commun. 122 (3): 877â€“83. doi:10.1016/0006-291X(84)91172-0. PMID 6433912.
|This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.|
Apolipoprotein A-II (ApoA-II) Provide feedback
Apolipoprotein A-II (ApoA-II) is the second major apolipoprotein of high density lipoprotein in human plasma. Mature ApoA-II is present as a dimer of two 77-amino acid chains joined by a disulphide bridge . ApoA-II regulates many steps in HDL metabolism, and its role in coronary heart disease is unclear . In bovine serum, the ApoA-II homologue is present in almost free form. Bovine ApoA-II shows antimicrobial activity against Escherichia coli and yeasts in phosphate buffered saline (PBS) .
Motizuki M, Itoh T, Yamada M, Shimamura S, Tsurugi K; , J Biochem (Tokyo) 1998;123:675-679.: Purification, primary structure, and antimicrobial activities of bovine apolipoprotein A-II. PUBMED:9538260 EPMC:9538260
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR006801Apolipoprotein A-II (ApoA-II) is the second major apolipoprotein of high density lipoprotein in human plasma. Mature ApoA-II is present as a dimer of two 77-amino acid chains joined by a disulphide bridge [PUBMED:12119188]. ApoA-II regulates many steps in HDL metabolism, and its role in coronary heart disease is unclear [PUBMED:12119188]. In bovine serum, the ApoA-II homologue is present in almost free form. Bovine ApoA-II shows antimicrobial activity against Escherichia coli and yeasts in phosphate buffered saline (PBS) [PUBMED:9538260].
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
|Cellular component||extracellular region (GO:0005576)|
|Molecular function||lipid binding (GO:0008289)|
|Biological process||lipid transport (GO:0006869)|
|lipoprotein metabolic process (GO:0042157)|
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|Number in seed:||13|
|Number in full:||66|
|Average length of the domain:||71.20 aa|
|Average identity of full alignment:||54 %|
|Average coverage of the sequence by the domain:||66.79 %|
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