Summary: Lantibiotic dehydratase, C terminus
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Lantibiotic dehydratase, C terminus Provide feedback
Lantibiotics are ribosomally synthesised antimicrobial agents derived from ribosomally synthesised peptides . They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin. Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydration of serine and threonine residues followed by addition of cysteine residues . This family constitutes the C-terminus of the enzyme proposed to catalyse the dehydration step .
Xie L, Chatterjee C, Balsara R, Okeley NM, van der Donk WA; , Biochem Biophys Res Commun 2002;295:952-957.: Heterologous expression and purification of SpaB involved in subtilin biosynthesis. PUBMED:12127987 EPMC:12127987
Karakas Sen A, Narbad A, Horn N, Dodd HM, Parr AJ, Colquhoun I, Gasson MJ; , Eur J Biochem 1999;261:524-532.: Post-translational modification of nisin. The involvement of NisB in the dehydration process. PUBMED:10215865 EPMC:10215865
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This tab holds annotation information from the InterPro database.
InterPro entry IPR006827Lantibiotics are ribosomally synthesised antimicrobial agents derived from ribosomally synthesised peptides [PUBMED:1539969]. They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin. Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydration of serine and threonine residues followed by addition of cysteine residues [PUBMED:12127987]. This family constitutes the C terminus of the enzyme proposed to catalyse the dehydration step [PUBMED:12127987, PUBMED:10215865].
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|Number in seed:||37|
|Number in full:||446|
|Average length of the domain:||415.20 aa|
|Average identity of full alignment:||17 %|
|Average coverage of the sequence by the domain:||49.92 %|
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build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
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