Summary: Securin sister-chromatid separation inhibitor
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Securin sister-chromatid separation inhibitor Provide feedback
Securin is also known as pituitary tumour-transforming gene product. Over-expression of securin is associated with a number of tumours, and it has been proposed that this may be due to erroneous chromatid separation leading to chromosome gain or loss .
Zou H, McGarry TJ, Bernal T, Kirschner MW; , Science 1999;285:418-422.: Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. PUBMED:10411507 EPMC:10411507
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This tab holds annotation information from the InterPro database.
InterPro entry IPR006940
Securin, also known as pituitary tumour-transforming gene product is a regulatory protein which plays a central role in chromosome stability in the p53/TP53 pathway, and in DNA repair. It probably acts by blocking the action of key proteins, for example, during mitosis it blocks Separase/ESPL1 function preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, leading to its destruction and to the liberation of ESPL1. Its function is however not limited to an inhibitory activity, since it is required to activate ESPL1. The negative regulation of the transcriptional activity and related apoptosis activity of TP53 may explain the strong transforming capability of the protein when it is overexpressed. Over-expression of securin is associated with a number of tumours, and it has been proposed that this may be due to erroneous chromatid separation leading to chromosome gain or loss [PUBMED:10411507].
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|Cellular component||nucleus (GO:0005634)|
|Biological process||chromosome organization (GO:0051276)|
|DNA metabolic process (GO:0006259)|
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|Seed source:||Pfam-B_4643 (release 7.6)|
|Number in seed:||8|
|Number in full:||108|
|Average length of the domain:||208.00 aa|
|Average identity of full alignment:||36 %|
|Average coverage of the sequence by the domain:||95.25 %|
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build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 23193494 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
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