Summary: Surfeit locus protein 6
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The surfeit locus protein SURF-6 is shown to be a component of the nucleolar matrix and has a strong binding capacity for nucleic acids .
Magoulas C, Zatsepina OV, Jordan PW, Jordan EG, Fried M; , Eur J Cell Biol 1998;75:174-183.: The SURF-6 protein is a component of the nucleolar matrix and has a high binding capacity for nucleic acids in vitro. PUBMED:9548374 EPMC:9548374
External database links
This tab holds annotation information from the InterPro database.
InterPro entry IPR029190
This entry represents the C-terminal domain of the ribosomal RNA-processing protein 14 (Rrp14), which shares protein sequence similarity with surfeit locus protein 6 (SURF6).
In mammals, SURF6 is a component of the nucleolar matrix and has a strong binding capacity for nucleic acids [PUBMED:9548374]. SURF6 is always found in the nucleolus regardless of the phase of the cell cycle suggesting that it is a structural protein constitutively present in nucleolar substructures. A role in rRNA processing has been proposed for this protein.
Saccharomyces cerevisiae member of the SURF-6 family, named Rrp14 (ribosomal RNA-processing protein 14), interacts with proteins involved in ribosomal biogenesis and cell polarity [PUBMED:15629442]. It is required for the synthesis of both 40S and 60S ribosomal subunits and may also play some direct role in correct positioning of the mitotic spindle during mitosis [PUBMED:17272295, PUBMED:17804645].
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Curation and family details
|Seed source:||Pfam-B_5497 (release 7.6)|
|Number in seed:||146|
|Number in full:||601|
|Average length of the domain:||202.80 aa|
|Average identity of full alignment:||27 %|
|Average coverage of the sequence by the domain:||49.13 %|
|HMM build commands:||
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 80369284 -E 1000 --cpu 4 HMM pfamseq
|Family (HMM) version:||8|
|Download:||download the raw HMM for this family|
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