Summary: Cell division protein FtsL
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Cell division protein FtsL Provide feedback
In Escherichia coli, nine gene products are known to be essential for assembly of the division septum. One of these, FtsL, is a bitopic membrane protein whose precise function is not understood. It has been proposed that FtsL interacts with the DivIC protein PF04977 [3] however this interaction may be indirect [4].
Literature references
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Guzman LM, Barondess JJ, Beckwith J; , J Bacteriol 1992;174:7716-7728.: FtsL, an essential cytoplasmic membrane protein involved in cell division in Escherichia coli. PUBMED:1332942 EPMC:1332942
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Sievers J, Errington J; , J Bacteriol 2000;182:5572-5579.: Analysis of the essential cell division gene ftsL of Bacillus subtilis by mutagenesis and heterologous complementation. PUBMED:10986263 EPMC:10986263
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Sievers J, Errington J; , Mol Microbiol 2000;36:846-855.: The Bacillus subtilis cell division protein FtsL localizes to sites of septation and interacts with DivIC. PUBMED:10844672 EPMC:10844672
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Robson SA, Michie KA, Mackay JP, Harry E, King GF; , Mol Microbiol 2002;44:663-674.: The Bacillus subtilis cell division proteins FtsL and DivIC are intrinsically unstable and do not interact with one another in the absence of other septasomal components. PUBMED:11994149 EPMC:11994149
Internal database links
SCOOP: | DivIC |
Similarity to PfamA using HHSearch: | DivIC |
This tab holds annotation information from the InterPro database.
InterPro entry IPR011922
FtsL is one of the later proteins active in cell division septum formation. FtsL is small, low in complexity, and highly divergent [PUBMED:12626683, PUBMED:10986263].
Gene Ontology
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
Cellular component | integral component of membrane (GO:0016021) |
Biological process | cell division (GO:0051301) |
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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Pfam Clan
This family is a member of clan FtsL (CL0225), which has the following description:
This clan includes two proteins that are known to interact, FtsL and DivIC which are part of a trimeric complex with DivIB [2]. DivIC and FtsL are bacterial proteins essential for cell division.
The clan contains the following 3 members:
DivIC FtsL ZapBAlignments
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets, the UniProtKB sequence database, the NCBI sequence database, and our metagenomics sequence database. More...
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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (35) |
Full (1562) |
Representative proteomes | UniProt (8757) |
NCBI (8777) |
Meta (273) |
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RP15 (128) |
RP35 (443) |
RP55 (1043) |
RP75 (2215) |
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key:
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not generated,
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
Seed (35) |
Full (1562) |
Representative proteomes | UniProt (8757) |
NCBI (8777) |
Meta (273) |
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RP15 (128) |
RP35 (443) |
RP55 (1043) |
RP75 (2215) |
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Raw Stockholm | |||||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
Trees
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
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Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Curation
Seed source: | COG3116 |
Previous IDs: | none |
Type: | Coiled-coil |
Sequence Ontology: | SO:0001080 |
Author: |
Bateman A |
Number in seed: | 35 |
Number in full: | 1562 |
Average length of the domain: | 90.80 aa |
Average identity of full alignment: | 27 % |
Average coverage of the sequence by the domain: | 83.39 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 47079205 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 97 | ||||||||||||
Family (HMM) version: | 14 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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